Who said differentiating preeclampsia from COVID-19 infection was easy?

Jayaram, Aswathi; Buhimschi, Irina A.; Aldasoqi, Hayfaa; Hartwig, Julie; Owens, Thomas; Elam, Gloria; Buhimschi, Catalin S.

doi:10.1016/j.preghy.2021.07.248

Cited by 14 publications

(13 citation statements)

References 6 publications

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“…However, the sFlt-1/PlGF ratio proved not to be helpful in the differential diagnosis of the severity of this infection; placental biomarkers did not correlate with the severity of symptoms, except for cases of severe respiratory failure, as described by Giardini and coworkers in non pregnant patients [9] . The highest value of sFlt-1/PlGF ratio was observed in the case of a severe COVID-19 pulmonary insufficiency requiring mechanical ventilation [22] .…”

Section: Discussionmentioning

confidence: 91%

sFlt-1/PlGF ratio in hypertensive disorders of pregnancy in patients affected by COVID-19

Soldavini

Martino

Sabattini

et al. 2022

Pregnancy Hypertension

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Objectives To analyze soluble Fms-like tyrosine Kinase 1 (sFlt-1) and Placental Growth Factor (PlGF) ratio concentrations in COVID-19 pregnant patients with and without Hypertensive Disorders of Pregnancy (HDP), compared with non COVID-19 pregnant patients with HDP and a control group. Study design : We recruited and obtained a complete follow-up of 19 COVID-19 pregnant patients with HDP and of 24 COVID-19 normotensive pregnant patients. Demographic, clinical and sFlt-1/PlGF ratio findings were compared with a group of 185 non COVID-19 pregnant patients with HDP and 41 non COVID normotensive patients. Findings were based on univariate analysis and on a multivariate adjusted model, and a case by case analysis of COVID-19 pregnant patients with an abnormal sFlt-1/PlGF ratio >38 at recruitment. Main outcome measures : sFlt-1/PlGF ratio. Results We confirmed a significant higher prevalence of HDP in women affected by COVID-19 compared to control population. sFlt-1/PlGF ratio was found high in HDP patients, with and without of Sars-Cov2 infection. COVID-19 patients with worse evolution of the disease showed greater rates of obesity and other comorbidities. sFlt/PlGF ratio proved not to be helpful in the differential diagnosis of the severity of this infection. Conclusions COVID-19 pregnant patients showed a higher prevalence of HDP compared to non COVID-19 controls, as well as higher comorbidity rates. In spite of the possible common endothelial target and damage, between Sars-Cov-2 infection and HDP, the sFlt1/PlGF ratio did not correlate with the severity of this syndrome.

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Section: Discussionmentioning

confidence: 91%

sFlt-1/PlGF ratio in hypertensive disorders of pregnancy in patients affected by COVID-19

Soldavini

Martino

Sabattini

et al. 2022

Pregnancy Hypertension

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“…COVID-19 during pregnancy is strongly associated with preeclampsia. COVID-19 severity does not seem to be a factor in this association [112]. Women with preeclampsia should be considered a particularly vulnerable group with regard to the risks posed by COVID-19 [111].…”

Section: Covid-19mentioning

confidence: 81%

An Update Review of the Pathogenesis Hypothesis in Preeclampsia

Li¹,

Zhu²,

Xi³

2022

Clin. Exp. Obstet. Gynecol.

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Objectives: Hypertensive disorders occur in approximately 12% to 22% of pregnancies and cause substantial perinatal morbidity and mortality of both mother and fetus. Hypertensive disease is directly responsible for approximately 20% of maternal deaths and can be classified as chronic hypertension, gestational hypertension, preeclampsia-eclampsia, and chronic hypertension with superimposed preeclampsia. At present, the pathogenesis of preeclampsia is still unclear, we wrote this article to make a uptodate review of this disease. Mechanism: A comprehensive search of several databases was conducted from inception up to March 2022. The searched databases were Web of Science, MEDLINE,Ovid, and Cochrane Database of Systematic Reviews. The search strategy included the combinations of the following medical terms: Hypertensive disorders; preeclampsia; mechanism; pathogenesis hypothesis. Findings in Brief: At present,the pathogenesis of preeclampsia is still unclear, the theory of Genetic,Inflammatory Response, Immune Imbalance in Maternal-Fetal Interface, Oxidative Stress, Vascular Endothelial Cell Damage are supposed involved in the progress of preeclampsia. Conclusions: Although there are various theories mentioned above, none of the hypothesis can fully explain preeclampsia. More research is needed on the mechanism of preeclampsia.

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“…Thank you for the opportunity to respond to the letter submitted by Dr. Sarkar and his team. We are thankful for their interest in our study [1] .…”

mentioning

confidence: 94%

“…As mentioned in our study we focused primarily on the episode of care. Our analysis included patients only if >20 weeks of gestation [1] . We agree inflammation could be the pathophysiologic link between COVID-19 infection and preeclampsia.…”

mentioning

confidence: 99%

Letter #1 Response to letter to Editor by Dr. Sarkar et al. for’ who said differentiating preeclampsia from COVID-19 infection was easy? Refers to PII: S2210-7789(21)00539-0 Letter #2 Response to letter to Editor by Dr. Hantoushzadeh et al. for’ is COVID-19 disease a risk factor for preeclampsia? Should aspirin be considered for prophylaxis of preeclampsia in these patients?’ Refers to PII: S2210-7789(21)00538-9

Jayaram

Buhimschi

2022

Pregnancy Hypertension

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Who said differentiating preeclampsia from COVID-19 infection was easy?

Cited by 14 publications

References 6 publications

sFlt-1/PlGF ratio in hypertensive disorders of pregnancy in patients affected by COVID-19

sFlt-1/PlGF ratio in hypertensive disorders of pregnancy in patients affected by COVID-19

An Update Review of the Pathogenesis Hypothesis in Preeclampsia

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