Whole blood omega-3 fatty acid concentrations are inversely associated with blood pressure in young, healthy adults

Filipovic, Mark G; Aeschbacher, Stefanie; Reiner, Martin F.; Stivala, Simona; Gobbato, Sara; Bonetti, Nicole R.; Risch, Martin; Risch, Lorenz; Camici, Giovanni G.; Luescher, Thomas F; Schacky, Clemens von; Conen, David; Beer, Jürg H.

doi:10.1097/hjh.0000000000001728

Cited by 34 publications

(35 citation statements)

References 53 publications

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“…an omega-3 index below the target range of 8-11 %, have been found in many countries and populations. A deficit in EPA and DHA is associated with increased total mortality, fatal and non-fatal cardiovascular events, stroke, impaired cognition, premature birth, perinatal mortality and other health issues (3)(4)(5)8,9,16,17,30,32,(37)(38)(39)45,47,48,54,63,64) . A deficit in EPA and DHA in the population studied is required for positive results of a randomised controlled intervention trial.…”

Section: Resultsmentioning

confidence: 99%

Omega-3 index in 2018/19

Schacky¹

2020

Proc. Nutr. Soc.

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The omega-3 index, the percentage of EPA plus DHA in erythrocytes (measured by standardised analysis), represents a human body's status in EPA and DHA. An omega-3 index is measured in many laboratories around the world; however, even small differences in analytical methods entail large differences in results. Nevertheless, results are frequently related to the target range of 8–11 %, defined for the original and scientifically validated method (HS-Omega-3 Index®), raising ethical issues, and calling for standardisation. No human subject has an omega-3 index <2 %, indicating a vital minimum. Thus, the absence of EPA and DHA cannot be tested against presence. Moreover, clinical events correlate with levels, less with the dose of EPA and DHA, and the bioavailability of EPA and DHA varies inter-individually. Therefore, the effects of EPA and DHA are difficult to demonstrate using typical drug trial methods. Recent epidemiologic data further support the relevance of the omega-3 index in the cardiovascular field, since total mortality, cardiovascular mortality, cardiovascular events such as myocardial infarction or stroke, or blood pressure all correlate inversely with the omega-3 index. The omega-3 index directly correlates with complex brain functions. Compiling recent data supports the target range for the omega-3 index of 8–11 % in pregnancy. Many other potential applications have emerged. Some, but not all health issues mentioned have already been demonstrated to be improved by increasing intake of EPA and DHA. Increasing the omega-3 index into the target range of 8–11 % with individualised doses of toxin-free sources for EPA and DHA is tolerable and safe.

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Section: Resultsmentioning

confidence: 99%

Omega-3 index in 2018/19

Schacky¹

2020

Proc. Nutr. Soc.

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“…Therefore, increasing intake of n-3 polyunsaturated fatty acids is widely considered to be safe and potentially beneficial toward different metabolism-related disorders. Moreover, it has been reported that a higher n-3 polyunsaturated fatty acid index is associated with statistically significant, clinically relevant lower systolic and diastolic blood pressure levels in normotensive young and healthy individuals [ 15 ]. From studies in animal models, it would seem that increasing the formation of metabolites of n-3 polyunsaturated fatty acids would also be an advantageous approach to improving health benefits of increased intake of EPA and DHA.…”

Section: Introductionmentioning

confidence: 99%

Effect of Dietary Content of Menhaden Oil with or without Salsalate on Neuropathic Endpoints in High-Fat-Fed/Low-Dose Streptozotocin-Treated Sprague Dawley Rats

Davidson

Coppey

Shevalye

et al. 2018

Journal of Diabetes Research

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In this study, we wanted to extend our investigation of the efficacy of fish oil with or without salsalate on vascular and neural complications using a type 2 diabetic rat model. Four weeks after the onset of hyperglycemia, diabetic rats were treated via the diet with 3 different amounts of menhaden oil with or without salsalate for 12 weeks. Afterwards, vascular reactivity of epineurial arterioles and neuropathy-related endpoints were examined. The addition of salsalate to high-fat diets enriched with 10% or 25% kcal of menhaden oil protected vascular reactivity to acetylcholine and calcium gene-related peptide, motor and sensory nerve conduction velocity, thermal nociception, intraepidermal nerve fiber density, and cornea sensitivity to a greater extent than 10% or 25% menhaden oil alone. Vascular and neural function was maximally protected with diet containing 45% kcal as menhaden oil, and adding salsalate did not provide any additional benefit. Salsalate alone in the high-fat diet of diabetic rats provided minimal protection/improvement of vascular and neural dysfunction. These studies imply that dietary salsalate in combination with lower amounts of menhaden oil can provide greater benefit toward diabetes-induced vascular and neural impairment than menhaden oil alone.

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“…B. [6,10,14,15,18,19,21,22,26,[36][37][38][39]). Da EPA+DHA in Erythrozyten mit EPA+DHA in allen anderen bisher untersuchten Zellen korreliert, ist der Omega-3-Index ein Biomarker für den EPA+DHA-Status einer Person [36].…”

Section: Gruppennomenklatur Der Fettsäuren Ist Unbrauchbarunclassified

“…Ein niedriger Omega-3-Index korreliert mit einem erhöhten Blutdruck [14]. Eine Erhöhung des Omega-3-Index senkt den Blutdruck und die Herzfrequenz, Triglyzeride und zahlreiche Biomarker der Inflammation, erhöht die Herzfrequenzvariabilität und verbessert die Endothelfunktion; das heißt, mehrere Surrogatparameter bzw.…”

Section: Kardiovaskuläre Präventionunclassified

“…[2]). Dies bedeutet, zusammen mit aktuellen epidemiologischen Daten, dass niedrige Spiegel von EPA+DHA in Erythrozyten eine Ursache von erhöhten Blutdruckwerten sein können [14]. In den Leitli-nien der European Society of Cardiology und European Society of Hypertension zur Hochdrucktherapie hingegen wird ohne wissenschaftliche Evidenz Olivenöl, nicht EPA+DHA, als blutdrucksenkend empfohlen [13].…”

Section: Blutdruckunclassified

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