Whole blood selenium content in pregnant women

Ferrer, Emilia; Alegrı́a, Amparo; Barberá, Reyes; Farré, R.; Lagarda, Marı́a Jesús; Monleón, Javier

doi:10.1016/s0048-9697(99)00008-x

Cited by 48 publications

(14 citation statements)

References 12 publications

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“…Some of the observed decrease in serum selenium during pregnancy has been attributed to hemodilution from the blood volume increase associated with pregnancy [22]. Another possible explanation for the decrease in serum selenium during pregnancy may be an increased requirement for this element, presumably for fetal growth [4].…”

Section: Discussionmentioning

confidence: 99%

Serum Selenium Concentrations Correlate Significantly with Inflammatory Biomarker High-sensitive CRP Levels in Hungarian Gestational Diabetic and Healthy Pregnant Women at Mid-pregnancy

Molnár

Garamvölgyi

Herold

et al. 2007

Biol Trace Elem Res

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Selenium is an essential trace element and a component of various enzymes with antioxidant functions. High-sensitive C-reactive protein (hsCRP) is an early indicator of increased lipid peroxidation. The serum selenium concentration, lipid parameters, and hsCRP values of gestational diabetic pregnant women (GD), control pregnant women (CP), and healthy nonpregnant controls (HC) were compared. Blood was taken between the 24th and the 28th week of pregnancy when the oral glucose tolerance test was performed. Selenium concentration was determined by atomic absorption spectrometry after hydride generation. HsCRP was measured by immunturbidimetry. HC had significantly higher serum selenium concentrations than GD and CP women (HC = 77.4 +/- 14.82, GD = 51.7 +/- 11.62, and CP = 40.5 +/- 8.03 microg/l, respectively). HsCRP values of both GD and nondiabetic pregnant women were significantly higher compared to controls. Significant negative correlations were found between serum selenium and total cholesterol, low-density lipoprotein cholesterol, and hsCRP values indicating that low selenium levels are associated with increased lipid peroxidation. Serum selenium concentrations of Hungarian pregnant women are low compared to internationally published data.

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Section: Discussionmentioning

confidence: 99%

Serum Selenium Concentrations Correlate Significantly with Inflammatory Biomarker High-sensitive CRP Levels in Hungarian Gestational Diabetic and Healthy Pregnant Women at Mid-pregnancy

Molnár

Garamvölgyi

Herold

et al. 2007

Biol Trace Elem Res

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“…In murine gestation, the fetus relies on maternal blood for its supply of selenium. 30 There is a significant decrease in selenium concentration in maternal blood, 31 with corresponding increases in placental and fetal levels, which become more pronounced as gestation proceeds. 30 In the present study, there was a gradual accumulation of selenium with gestational age in embryonic tissue.…”

Section: Discussionmentioning

confidence: 99%

Embryopathy in experimental diabetic gestation: assessment of oxidative stress and antioxidant defence

El-Bassiouni¹,

Helmy²,

Rawash³

et al. 2005

British Journal of Biomedical Science

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Maternal diabetes is associated with an increased rate of congenital fetal anomaly. In the present study, diabetes was induced by streptozotocin in female rats one week prior to conception and the embryos were examined during organogenesis. Experimental diabetes is associated with over-production of free radicals and disturbed antioxidant defence, particularly in malformed embryos. Oxidative stress is demonstrated by increased MDA accumulation and reduced glutathione levels. Despite large differences in the reduced/oxidised glutathione ratios during organogenesis in the control, diabetic non-malformed and malformed embryo groups, the half-cell redox potential was constant for each group during the experimental period. Calculated redox potentials indicated that although embryo cells from the control and diabetic mother groups were of the same chronological age, the stages of development were different. Increased oxidative stress in rat embryos was associated with increased glutathione peroxidases and glutathione-S-transferase activity. This may, in part, provide an explanation for the observed accumulation of oxidised glutathione in malformed embryos. Moreover, decreased levels of vitamin C and selenium were observed. Increased oxidative stress and perturbations in antioxidant defence contribute to the high incidence of congenital anomalies in experimental diabetic gestation.

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“…In the normal pregnancy, serum Se levels of control mothers with healthy newborns just after delivery fell to values significantly below those of the non- [20] and Ferrer et al [21] in normal pregnancy. Although the Se requirement during pregnancy are unknown, on a defined diet of 150 lg of Se per day, pregnant women had an increased conservation of Se compared with nonpregnant women [22].…”

Section: Discussionmentioning

confidence: 64%

Low levels of selenium in miscarriage

Güvenç

Güven

Karataş

et al. 2002

J Trace Elements Exper Med

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Few data are presented in the literature about selenium and miscarriage. The aim of this article was to study the relationship between the selenium status of pregnant women and miscarriage. A randomized, controlled trial was performed in Elazig State Hospital and Firat University Hospital. Serum and hair samples were obtained from 20 non-pregnant women, 32 healthy mothers with normal newborns, and 16 women who miscarried. Serum selenium levels, as ng/mL, and hair selenium levels, as ng/g, were determined on a PerkinÀElmer 1000 spectrophotometer by fluorometry. The mean serum and hair selenium concentrations of the women who miscarried (42.8 2.7 ng/mL, 276 6.6 ng/g, respectively) were significantly lower than those of the control healthy mothers (50.2 2.3 ng/mL, 300 6.1 ng/g, respectively) and the nonpregnant women (58.1 3.1 ng/mL, 315 7.6 ng/g, respectively). Maternal selenium deficiency during early gestation was thought to be one of the factors responsible in the pathogenesis of miscarriage. More studies on maternal selenium status during pregnancy are needed. J. Trace Elem. Med. 15:97À101, 2002.

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Whole blood selenium content in pregnant women

Cited by 48 publications

References 12 publications

Serum Selenium Concentrations Correlate Significantly with Inflammatory Biomarker High-sensitive CRP Levels in Hungarian Gestational Diabetic and Healthy Pregnant Women at Mid-pregnancy

Serum Selenium Concentrations Correlate Significantly with Inflammatory Biomarker High-sensitive CRP Levels in Hungarian Gestational Diabetic and Healthy Pregnant Women at Mid-pregnancy

Embryopathy in experimental diabetic gestation: assessment of oxidative stress and antioxidant defence

Low levels of selenium in miscarriage

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