Whole blood viscosity is negatively associated with bone mineral density in postmenopausal women with osteoporosis

Teng, Zhaogang; Pei, Li-chun; Zhang, Ying; Li, Ying

doi:10.1016/j.bone.2013.07.001

Cited by 9 publications

(8 citation statements)

References 30 publications

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“…Of those, two studies were performed in Italy, six in the US, three in China, three in Japan, two in Turkey, two in Korea, one in Morocco, one in Romania, one in Poland, one in Austria, one in Iran, one in Egypt, and one in Finland. Participants ranged in age from 46 to 89 years, and five of the studies included both males and females [ 5 , 18 , 24 , 26 , 37 ]. Nineteen studies included only post-menopausal individuals and one only consisted of male participants [ 15 – 17 , 23 , 25 , 28 – 30 , 32 – 35 , 37 , 39 – 42 ].…”

Section: Resultsmentioning

confidence: 99%

Decreased Bone Mineral Density Is an Independent Predictor for the Development of Atherosclerosis: A Systematic Review and Meta-Analysis

Wang

et al. 2016

PLoS ONE

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BackgroundThere is conflicting evidence regarding the association between decreased bone mineral density (BMD) and atherosclerosis. To this end, we performed a systematic review and meta-analysis to clarify the association.MethodsTo identify relevant studies, PubMed, Embase, and the Cochrane Library were systematically searched up to November 2015. All observational and comparative studies directly investigating the relationship between decreased BMD and clinical consequences of atherosclerotic vascular abnormalities, including carotid artery calcification (CAC), cardiovascular disease (CAD), and coronary artery disease (CAD) were obtained, without limitation of language or publication year.ResultsA total of 25 studies involving 10,299 patients were included. The incidence of atherosclerotic vascular abnormalities was significantly increased in low BMD patients, compared to patients with normal BMD (OR, 1.81, 95% CI [1.01, 2.19], p<0.00001)). Similar results were also observed for postmenopausal women (OR, 2.23, 95% CI [1.72, 2.89], p<0.00001). Subgroup analyses of osteopenia, osteoporosis, and normal BMD also revealed that the combined ORs for the incidence of atherosclerotic vascular abnormalities increased as BMD decreased. Of note, after adjusting for age, sex, body mass index (BMI) and other vascular risk factors, decreased BMD remained significantly associated with the incidence of atherosclerotic vascular abnormalities (OR, 2.96, 95% CI [2.25, 3.88], p < 0.00001).ConclusionsBased on the results of this study, decreased BMD is an independent predictor for the development of atherosclerosis in elderly individuals. Moreover, the risk of atherosclerotic vascular abnormalities increased as BMD decreased. Future studies focusing on individuals with different severities of atherosclerosis and comorbidities are of interest.

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Section: Resultsmentioning

confidence: 99%

Decreased Bone Mineral Density Is an Independent Predictor for the Development of Atherosclerosis: A Systematic Review and Meta-Analysis

Wang

et al. 2016

PLoS ONE

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“…6 Furthermore, eWBV is increased in many chronic illnesses such as hypertension, metabolic syndrome, diabetes mellitus (DM), CVD, and stroke. [7][8][9] Additionally, several large prospective studies have shown the important link between eWBV and the risk of primary CVE. 10,11 Cardiovascular diseases beginning with shear stress are the major cause of mortality in patients with CKD.…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between Plasma Whole Blood Viscosity and Cardiovascular Events in Patients With Chronic Kidney Disease

Çelik

Yılmaz

Balta

et al. 2016

Clin Appl Thromb Hemost

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Background: Plasma levels of estimated whole blood viscosity (eWBV) have been increased by endothelial inflammation. Because there were no consistent data for assessing the eWBV levels for prediction of cardiovascular event (CVE) in patients with chronic kidney disease (CKD). We aimed to investigate the relationship between plasma eWBV levels and CVEs in patients with CKD. Materials and Methods: We conducted a prospective, cross-sectional, long-term follow-up study, assessing the relationship between plasma eWBV levels and CVE (either fatal or nonfatal) in patients with newly diagnosed CKD. We also evaluated estimated glomerular filtration rate (eGFR), pentraxin 3 (PTX3), high-sensitivity C-reactive protein (hsCRP), and flow-mediated dilatation (FMD). Results: Study patients were divided into 2 groups: patients with CVE and patients without CVE. The eWBV levels were higher in patients with CVE. Additionally, PTX3 and hsCRP were higher, and FMD and eGFR were lower in patients with CVE compared to those without CVE. According to the Cox regression analysis, WBV, plasma asymmetric dimethylarginine levels, FMD, hsCRP, eGFR, systolic blood pressure, calcium, and history of diabetes were independent predictors of CVEs in patients with CKD. Kaplan Meier survival curves were generated to establish the impact of the WBV on the cumulative survival of the cohort. Patients with eWBV values higher than 5.2 centipoise (cP) had lower survival rates when compared to patients with eWBV values lower than 5.2 cP (log rank ¼ 4.49 df ¼ 1 P ¼ .034). Conclusion: In conclusion, plasma eWBV levels may increase the presence of lower eGFR and affect CVE in patients with CKD independent of classical and unconventional risk factors.

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“…Moreover, plasma viscosity and WBV are parameters that determine tissue blood supply, and deterioration of physiological functioning is inevitable in tissues with insufficient blood supply. Teng et al 20 showed a negative correlation between bone mineral density and WBV in a study that included 163 participants with postmenopausal osteoporosis, 155 with osteopenia, and 163 control participants. Moreover, they emphasized that osteoporosis is associated with cardiovascular disease and has been shown to be an independent predictor of cardiovascular mortality 20 .…”

Section: Discussionmentioning

confidence: 99%

“…Teng et al 20 showed a negative correlation between bone mineral density and WBV in a study that included 163 participants with postmenopausal osteoporosis, 155 with osteopenia, and 163 control participants. Moreover, they emphasized that osteoporosis is associated with cardiovascular disease and has been shown to be an independent predictor of cardiovascular mortality 20 . The hypothesis that increased plasma viscosity may be one of the mechanisms linking conventional risk factors to the risk of cardiovascular disease and that appropriate lifestyle changes may decrease its incidence was proposed in a study by Bonithon-Kopp et al 22 In addition, a study published in Menopause that evaluated postmenopausal women with glaucoma reported that plasma viscosity and Doppler parameters (ophthalmic artery mean improvements of pulsatility index, peak systolic blood flow velocity, and time-averaged maximum velocity) were significantly improved after 6 months of HT 23 .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the relationship between plasma viscosity and selected menopausal symptoms using the Menopause Rating Scale

et al. 2022

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Objective: The aim of this study was to investigate whether whole blood viscosity and plasma viscosity are associated with the severity of postmenopausal symptoms using the Menopause Rating Scale (MRS).Methods: This study included 108 postmenopausal women admitted to menopause clinics. Participants were divided into two groups according to their MRS scores. Groups 1 (n = 52) and 2 (n = 56) were composed of healthy postmenopausal women with MRS scores of <14 and ≥14 points, respectively. The clinical findings and hemorheological parameters were compared between the two groups.Results: Comparing plasma viscosity levels between the two groups showed that group 1 had 1.25 ± 0.08 centipoise, whereas group 2 had 1.30 ± 0.10 centipoise ( P = 0.03). The difference in plasma viscosity between the two groups persisted after adjustment for age (1.24 ± 0.08 vs 1.31 ± 0.10; P < 0.001). Plasma viscosity was also significantly correlated with age (r = 0.384, P < 0.001), menopausal duration (r = 0.362, P < 0.001), and urogenital symptoms (r = 410, P < 0.001).Conclusions: Increased plasma viscosity levels were significantly associated with selected postmenopausal symptoms, independent of age.

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Whole blood viscosity is negatively associated with bone mineral density in postmenopausal women with osteoporosis

Cited by 9 publications

References 30 publications

Decreased Bone Mineral Density Is an Independent Predictor for the Development of Atherosclerosis: A Systematic Review and Meta-Analysis

Decreased Bone Mineral Density Is an Independent Predictor for the Development of Atherosclerosis: A Systematic Review and Meta-Analysis

The Relationship Between Plasma Whole Blood Viscosity and Cardiovascular Events in Patients With Chronic Kidney Disease

Evaluation of the relationship between plasma viscosity and selected menopausal symptoms using the Menopause Rating Scale

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