Whole-body aerosol exposure of cadmium chloride (CdCl2) and tetrabromobisphenol A (TBBPA) induced hepatic changes in CD-1 male mice

Chen, Yuanhong; Hu, Yabing; Liu, Shuyun; Zheng, Huiying; Wu, Xiaojuan; Huang, Zhiyong; Li, Hao; Peng, Bao-qi; Long, Jinlie; Pan, Bishu; Huang, Changjiang; Dong, Qian

doi:10.1016/j.jhazmat.2016.06.054

Cited by 25 publications

(12 citation statements)

References 45 publications

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“…Measuring of enzymatic and non-enzymatic antioxidant activities in our study emphasizes the protection of purslane on Cd-induced oxidative stress. Cd decreased the activities of SOD, CAT, and GPx in liver homogenates of rats were also reported by Chen et al [52]…”

Section: Discussionsupporting

confidence: 77%

“…The protective effect of P. oleracea may be due to its constituents from the active components as Flavonoids, polyphenols, and Alkaloids. Polyphenols have been reported to possess a membrane stabilizing activity by inhibiting the generation of ROS induced by Cd and maintain the cell membrane structural integrity [52]. Our findings exhibited elevation in liver enzymes in Cd-treated group.…”

Section: Discussionsupporting

confidence: 55%

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Hepato-Renal protective Effects of Egyptian Purslane Extract against Experimental Cadmium Toxicity in Rats with Special Emphasis on the Functional and Histopathological Changes

et al. 2019

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Section: Discussionsupporting

confidence: 77%

Section: Discussionsupporting

confidence: 55%

Hepato-Renal protective Effects of Egyptian Purslane Extract against Experimental Cadmium Toxicity in Rats with Special Emphasis on the Functional and Histopathological Changes

et al. 2019

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“…Cd mediated decrease in levels of reduced glutathione and decrease in the activities of SOD, CAT, GST and GPx in the liver of rats were also reported by Chen et al. and Adaramoye and Akanni which are in line with our reports [40], [41]. T .…”

Section: Discussionsupporting

confidence: 92%

Tinospora cordifolia extract prevents cadmium-induced oxidative stress and hepatotoxicity in experimental rats

Baskaran

Priya

Kumar

et al. 2018

Journal of Ayurveda and Integrative Medicine

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BackgroundCadmium (Cd) pollution is of serious concern due to its toxic effects in both humans and animals. The study investigates the protective effect of Tinospora cordifolia stem methanolic extract (TCME) on Cd induced hepatotoxicity.Objective(s)The objective of the study was to explore the hepatoprotective effects of T. cordifolia extract.Materials and methodsRats were administered orally with Cd (5 mg/kg) and TCME (100 mg/kg) for 28 days. At the end of the treatment period, serum and liver tissues homogenates were subjected to biochemical analysis.ResultsCd treated rats showed increased activities of the serum marker enzymes of liver damage such as AST and ALT along with increased levels of LPO and protein carbonyl content in liver tissues. Cd treatment also leads to decreased activities of endogenous antioxidants (SOD, CAT, GSH, GPx and GST), membrane ATPases (Na+K+ATPase, Ca2+ATPase and Mg2+K+ATPase) and the tissue glycoprotein levels (hexose, fucose, hexosamine and sialic acid). Histological analysis revealed vacuolar degeneration of hepatocytes with focal necrosis upon Cd administration. TCME co-treatment restored the biochemical and histological alterations caused by Cd intoxication to near normal levels.ConclusionThe results of the present investigation reveal the hepatoprotective nature of T.cordifolia against Cd induced hepatotoxicity.

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“…Considering liver-related AOs (hepatotoxicity and liver cancer), evidence for TDCIPP, TCEP, TMPP, TBBPA, TPhP and TNBP relied exclusively on animal studies [9,10,15,67,68,72]. Our search identified AOP 144 (all AOPs listed in Table 4) as a plausible mechanism for TMPP-, TBBPA-, TPhP-, TNBP-and TDCIPP-induced hepatotoxicity, and AOP 220 as a plausible mechanism for TCEP-, TBBPA-, TNBP-and TDCIPP-induced liver cancer.…”

Section: Plausible Aops For the Observed Aos Of Cat I Frsmentioning

confidence: 99%

Prioritization of hazards of novel flame retardants using the mechanistic toxicology information from ToxCast and Adverse Outcome Pathways

2019

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Background: Flame retardants (FRs) are used in most consumer products and textiles to comply with current flammability standards. After the restriction of polybrominated diphenyl ethers, a large number of chemically diverse replacement FRs are increasingly used, but the risk they represent is not yet properly evaluated and their toxicity pathways are still poorly understood. Approach:We collected in vivo toxicological information on 62 (including 52 non-regulated) FRs and established five prioritization categories (Cat I to V) based on data availability and toxicological concern. We then considered available in vitro toxicological data from ToxCast, as a complement to in vivo information. By combining these information sources, we then explored relevant toxicity mechanisms for nine selected FRs (Cat I) using the AOP (Adverse Outcome Pathway) framework. Results:For 20 FRs (Cat V), toxicological data on mammals were absent. Data available were scarce for another 22 FRs, of which 14 FRs (Cat II) may be of toxicological concern. We found substantial information for only ten replacement FRs, of which nine (Cat I) present some toxicological concern: tris-2-chloroethyl phosphate (TCEP), tris(1,3dichloropropyl)phosphate (TDCIPP), triphenyl phosphate (TPhP), tricresyl phosphate (TMPP), tetrabromobisphenol A (TBBPA), tri-n-butyl phosphate (TNBP), tri(2-butoxyethyl) phosphate (TBOEP), tris(1-chloro-2-propyl) phosphate (TCIPP), 2-ethylhexyl diphenyl phosphate (EHDPP). ToxCast results confirmed in vivo based categorization for several FRs and identified potential molecular targets. For the nine Cat I FRs, we identified several molecular targets, health outcomes and some potential AOPs. However, the complete toxicity pathways leading from molecular targets to adverse health outcomes are still unknown, with the exception of TBBPA-induced neurotoxicity. Conclusions:The approach presented in this study was particularly useful for the categorization of a large group of replacement FRs with relatively low data availability. We highlight priority compounds that critically need more toxicological studies or FRs for which regulatory measures could be envisaged. Our research also suggests that high toxicity indicated by ToxCast is particularly relevant for predicting higher hazard in vivo. Finally, we indicate several gaps and directions for future research, such as molecular targets that could be tested in vitro and health outcomes for cohort studies. which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Whole-body aerosol exposure of cadmium chloride (CdCl2) and tetrabromobisphenol A (TBBPA) induced hepatic changes in CD-1 male mice

Cited by 25 publications

References 45 publications

Hepato-Renal protective Effects of Egyptian Purslane Extract against Experimental Cadmium Toxicity in Rats with Special Emphasis on the Functional and Histopathological Changes

Hepato-Renal protective Effects of Egyptian Purslane Extract against Experimental Cadmium Toxicity in Rats with Special Emphasis on the Functional and Histopathological Changes

Tinospora cordifolia extract prevents cadmium-induced oxidative stress and hepatotoxicity in experimental rats

Prioritization of hazards of novel flame retardants using the mechanistic toxicology information from ToxCast and Adverse Outcome Pathways

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