Whole-Body Autoradiography of Pharmaceuticals and Chemicals

Bénard, P.

doi:10.1007/978-94-011-3094-3_2

Cited by 3 publications

(1 citation statement)

References 67 publications

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“…This was performed according to the Ullberg method (9) that we previously described (10).The animals were deeply frozen by rapid and total immersion in a methanol-dry ice medium (-75 DC). The frozen animals were decapitated and the heads were embedded in carboxy-methyl cellulose on a microtome stage immersed in a freezing bath.…”

Section: Whole Body Autoradiographymentioning

confidence: 99%

Autoradiography in brain ofMacaca fascicularis monkeys after injection of acetyl-DL-leucine [2-14C] (Tanganil®)

Bénard

Cousse

Bengone

et al. 2001

Eur. J. Drug Metab. Pharmacokinet.

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Acetyl-DL-leucine [2-14C]: Tanganil a antivertigal drug has been injected intravenously in two macaca monkeys which have been sacrificed 2 and 5 minutes later. Radioactivity distribution has been studied by autoradiography in the brain. An important uptake of radioactivity is localized in the cortical structures and in several tisses such as nuclei of the vestibular system, including the inner ear.

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Section: Whole Body Autoradiographymentioning

confidence: 99%

Autoradiography in brain ofMacaca fascicularis monkeys after injection of acetyl-DL-leucine [2-14C] (Tanganil®)

Bénard

Cousse

Bengone

et al. 2001

Eur. J. Drug Metab. Pharmacokinet.

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Distribution study of radioactivity in rats after oral administration of the lipido/sterolic extract ofSerenoa repens (Permixon®) supplemented with [1-14C]-lauric acid, [1-14C]-oleic acid or [4-14C]-β-sitosterol

Chevalier

Bénard

Cousse

et al. 1997

European Journal of Drug Metabolism and Pharmacokinetics

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The study carried out on rats given orally the n-hexane lipido/sterolic extract of Serenoa repens (LSESR), supplemented with [14C]-labelled oleic or lauric acids or beta-sitosterol, demonstrated that radioactivity uptake in prostatic tissues shows the highest level in the case of administration of LSESR supplemented with [14C]-labelled oleic acid. This was clearly demonstrated on a rat with an induced fibro-muscular hyperplasia of the prostate and by quantitative measurements of radioactivity. Ratios of radioactivity in tissues compared to plasma show an uptake of radioactivity greater in prostate as compared to other genital organs, i.e. the seminal vesicles or to other organs such as liver.

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Nephrotoxicity: A better mechanistic understandings using histochemistry and cytochemistry

Bach

1991

Progress in Histochemistry and Cytochemistry

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Whole-Body Autoradiography of Pharmaceuticals and Chemicals

Cited by 3 publications

References 67 publications

Autoradiography in brain ofMacaca fascicularis monkeys after injection of acetyl-DL-leucine [2-14C] (Tanganil®)

Autoradiography in brain ofMacaca fascicularis monkeys after injection of acetyl-DL-leucine [2-14C] (Tanganil®)

Distribution study of radioactivity in rats after oral administration of the lipido/sterolic extract ofSerenoa repens (Permixon®) supplemented with [1-14C]-lauric acid, [1-14C]-oleic acid or [4-14C]-β-sitosterol

Nephrotoxicity: A better mechanistic understandings using histochemistry and cytochemistry

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