Whole body leucine metabolism in adolescents with Crohn's disease and growth failure during nutritional supplementation

Motil, Kathleen J.; Grand, Richard J.; Matthews, Dwight E.; Bier, Dennis M.; Maletskos, C.J.; Young, Vernon R.

doi:10.1016/0016-5085(82)90070-1

Cited by 46 publications

(15 citation statements)

References 12 publications

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“…Motil et al (98) likewise found an increase in leucine balance equivalent to +23 mg nitrogen/kg with an additional energy intake of 11 kcallkg, exactly in agreement with the classical relationship. but this cannot be the whole story.…”

Section: Energy In Takesupporting

confidence: 57%

“…In normal subjects, moderate increases or decreases of energy of the order of 25% produced no detectable changes in leucine flux or in protein synthesis and breakdown (98,162). In normal subjects, moderate increases or decreases of energy of the order of 25% produced no detectable changes in leucine flux or in protein synthesis and breakdown (98,162).…”

Section: Energy In Takementioning

confidence: 95%

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Whole-Body Protein Turnover in Humans—Past, Present, and Future

Waterlow

1995

Annu. Rev. Nutr.

115

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Protein turnover is a fundamental biological process in all living organisms. The study of protein turnover in human subjects, and in the body as a whole, is of relatively recent origin. In this review, I summarize briefly how this field of work has expanded over the past 25 years, with emphasis on conceptual problems and controversies, particularly those related to methods of measurement. We cannot be certain that our estimates are accurate because no method of verification exists, but progress will be made through successive approximations. Some of the applications are described in different physiological and pathological states such as growth and trauma, and possible directions for fruitful future research are indicated.

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Section: Energy In Takesupporting

confidence: 57%

Section: Energy In Takementioning

confidence: 95%

Whole-Body Protein Turnover in Humans—Past, Present, and Future

Waterlow

1995

Annu. Rev. Nutr.

115

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“…Such is indeed the case: the weight gain of patients with anorexia nervosa during nutritional rehabilitation consists of 64% LBM (Forbes et aI., 1984), and Barac-Nieto et al (1979) found that LBM made up 68% of the weight gained by undernourished men during nutritional repletion. Motil et al (1982) supplemented the diet of undernourished adolescents who had Crohn's disease. Energy intake was increased from 67 to 96 kcal/kg body weight per day, and protein intake from 2.3 to 3.2 g/kg/day.…”

Section: Weight Gainmentioning

confidence: 69%

Human Body Composition

Forbes

1987

326

151

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“…Inflammation can influence food intake and lead to growth disruption, and growth failure has been reported in adolescents with Crohn's disease [33]. The growth rate of HLA-B27 rats has been documented poorly.…”

Section: Discussionmentioning

confidence: 99%

Increased tissue protein synthesis during spontaneous inflammatory bowel disease in HLA-B27 rats

et al. 2003

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Inflammatory bowel diseases (IBDs) are associated with an increased whole-body protein turnover. In certain drug-induced experimental models of IBD, disturbances of protein synthesis in tissues have been reported recently, but it is unclear if similar disturbances occur in other chronic intestinal diseases. Therefore we investigated changes in protein synthesis in different tissues of HLA-B27 (human leucocyte antigen B27) transgenic rats that develop spontaneously chronic inflammation, with major involvement of the colon. Protein synthesis rate in HLA-B27 rats was shown to be higher in nine different tissues compared with control (Fisher 344) rats. The absolute rate of protein synthesis was highly stimulated at the main inflammatory site (+290% in the colon). However, liver, muscle and skin appeared to be major contributors to the increased protein synthesis observed at the whole-body level. Despite the increased protein synthesis, HLA-B27 rats presented a marked atrophy of muscles, which suggests an increased proteolysis. These results contrast with metabolic disturbances described in acute inflammation and colitis induced by drugs (i.e. dextran sodium sulphate). The present study suggests that the modifications of protein metabolism are strongly influenced by the type of the inflammatory diseases and thus by the underlying mechanisms, which result in different metabolic adaptations and specific nutritional requirements.

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Whole body leucine metabolism in adolescents with Crohn's disease and growth failure during nutritional supplementation

Cited by 46 publications

References 12 publications

Whole-Body Protein Turnover in Humans—Past, Present, and Future

Whole-Body Protein Turnover in Humans—Past, Present, and Future

Human Body Composition

Increased tissue protein synthesis during spontaneous inflammatory bowel disease in HLA-B27 rats

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