2022
DOI: 10.1016/j.csbj.2022.07.019
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Whole-body metabolic modelling predicts isoleucine dependency of SARS-CoV-2 replication

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Cited by 15 publications
(17 citation statements)
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“…The approaches analysed different SARS-CoV-2 variants (e.g., see [ 99 , 105 ]) and infection dynamics in different cell types [ 109 ]. Finally, whole-body models were applied to analyse the consequences of the infection on the whole human body [ 110 ]. Context-specific GEMs have, thus, been able to confirm existing COVID-19 treatment strategies, as well as resulted in proposals of novel drug targets and repurposed drugs for effective treatment.…”
Section: Discussionmentioning
confidence: 99%
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“…The approaches analysed different SARS-CoV-2 variants (e.g., see [ 99 , 105 ]) and infection dynamics in different cell types [ 109 ]. Finally, whole-body models were applied to analyse the consequences of the infection on the whole human body [ 110 ]. Context-specific GEMs have, thus, been able to confirm existing COVID-19 treatment strategies, as well as resulted in proposals of novel drug targets and repurposed drugs for effective treatment.…”
Section: Discussionmentioning
confidence: 99%
“…Recently, Thiele et al presented a set of personalised sex-specific whole-body metabolic (WBM) GEMs [ 126 ]. These were also applied in the context of the analysis of metabolic reprogramming followed by SARS-CoV-2 infection [ 110 ]. Even though WMB models could describe the metabolism of a large number of organs in the human body [ 110 ], they only account for the (steady-state) response of metabolic networks, which are isolated from other biological networks.…”
Section: Discussionmentioning
confidence: 99%
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“…Proinflammatory cytokines convert tryptophan to kynurenine, which is associated with IL-6 peaks during acute SARS-CoV-2 infection. [149][150][151] Typically, kynurenine pathway activation is associated with immunosuppression. 152 Blocking aryl hydrocarbon receptor (AhR) signaling reduces liver fibrosis, kynurenine activates AhR as a ligand in T cells and regulates tumor immunity.…”
Section: Amino Acid Metabolismmentioning
confidence: 99%