Whole‐body MRI for metastatic cancer detection using T<sub>2</sub>‐weighted imaging with fat and fluid suppression

Wang, Xinzeng; Pirasteh, Ali; Brugarolas, James; Rofsky, Neil M.; Lenkinski, Robert E.; Pedrosa, Iván; Madhuranthakam, Ananth J.

doi:10.1002/mrm.27117

“…Previous studies have used the hybrid homodyne reconstruction, when partial k‐space data were acquired in 2 directions 25 . However that approach is associated with residual ringing artifacts with larger reduction factors.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have used the hybrid homodyne reconstruction, when partial k-space data were acquired in 2 directions. 25 However that approach is associated with residual ringing artifacts with larger reduction factors. We introduced a bi-directional homodyne reconstruction, which substantially reduced the ringing artifacts and achieved good image quality.…”

Section: Discussionmentioning

confidence: 99%

Single‐shot RARE with Dixon: Application to robust abdominal imaging with uniform fat and water separation at 3T

Wang

¹

,

Udayakumar

²

,

Xi

³

et al. 2021

Magnetic Resonance in Med

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Purpose To develop a true single shot turbo spin echo (SShTSE) acquisition with Dixon for robust T2‐weighted abdominal imaging with uniform fat and water separation at 3T. Methods The in‐phase (IP) and out‐of‐phase (OP) echoes for Dixon processing were acquired in the same repetition time of a SShTSE using partial echoes. A phase‐preserved bi‐directional homodyne reconstruction was developed to compensate the partial echo and the partial phase encoding of SShTSE. With IRB approval, the SShTSE‐Dixon was compared against standard SShTSE, without and with fat suppression using spectral adiabatic inversion recovery (SPAIR) in 5 healthy volunteers and 5 patients. The SNR and contrast ratio (CR) of spleen to liver were compared among different acquisitions. Results The bi‐directional homodyne reconstruction successfully minimized ringing artifacts because of partial acquisitions. SShTSE‐Dixon achieved uniform fat suppression compared to SShTSE‐SPAIR with fat suppression failures of 1/10 versus 10/10 in the axial plane and 0/5 versus 5/5 in the coronal plane, respectively. The SNRs of the liver (12.2 ± 4.9 vs. 11.7 ± 5.2; P = .76) and spleen (25.9 ± 11.6 vs. 23.7 ± 9.7; P = .14) were equivalent between fat‐suppressed images (SShTSE‐Dixon water‐only and SShTSE‐SPAIR). The SNRs of liver (14.4 ± 5.7 vs. 13.4 ± 5.0; P = .60) and spleen (26.5 ± 10.1 vs. 25.7 ± 8.5; P = .56) were equivalent between non‐fat‐suppressed images (SShTSE‐Dixon IP and SShTSE). The CRs of spleen to liver were also similar between fat‐suppressed images (2.6 ± 0.4 vs. 2.5 ± 0.5; P =.92) and non‐fat‐suppressed images (2.3 ± 0.6 vs. 2.2 ± 0.4; P =.84). Conclusion SShTSE‐Dixon generates robust abdominal T2‐weighted images at 3T with and without uniform fat suppression, along with perfectly co‐registered fat‐only images in a single acquisition.

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“…It shows high sensitivity in detecting bone marrow metastases, high intrinsic soft tissue contrast resolution, precise de nition of intraspinal tumor extension, good delineation of diaphragmatic involvement of thoracic tumors [26,19]. WB MRI may represent a radiation-free alternative in the assessment of patients with NB and its feasibility has already been demonstrated for the work-up of oncologic patients with various neoplastic diseases, (e.g., melanoma, breast, colorectal, prostate cancers) or for hematologic diseases with nodal or bone marrow involvement (lymphoma, multiple myeloma) [27,28]. WB MRI uses both conventional sequences which provide predominantly anatomical information, such STIR e T1 weighted sequences, and functional sequences, such DWI and/or DWIBS.…”

Section: Discussionmentioning

confidence: 99%

Whole-Body MRI and Whole Body 123I-MIBG scintigraphy: comparison in Lines and High Risk Neuroblastoma. A pilot study.

Olianti

¹

,

Perrone

²

,

Neri

³

et al. 2021

Preprint

0

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Purpose: To assess agreement between 123I-metaiodobenzylguanidine (MIBG) and Whole Body Magnetic Resonance Imaging with diffusion-weighted whole-body imaging with background body signal suppression (WB MRI-DWIBS) in High and Low, Intermediate risk neuroblastoma, a retrospective review was performed on MIBG and DWIBS paired scans acquired at diagnosis, response-to-therapy steps, after-surgery, off therapy.Methods: 80 paired MIBG and DWIBS scans were acquired for 31 patients between June 2009 and June 2019 within 30 days, without intercurrent therapy. SIOPEN Semi-quantitative scoring systems for NB with 12 body sections was applied at whole body MIBG and WB MRI-DWIBS acquired to evaluate the disease extent. We evaluated specificity, sensitivity, overall accuracy, positive predictive value (PPV) and negative predictive value (NPV) of WB MRI-DWIBS respect MIBG scintigraphy considered as gold standard, and vice versa.Results: DWIBS and MIBG images were concordant in 890 out of the 960 analyzed segments, with high agreement between the two techniques (kendal =0.85 P<0.0001 and Chi 536.5975 p<0.0001). Considering MIBG as gold standard, WB MRI-DWIBS overall accuracy was 93%, sensitivity 78%, specificity 95%, PPV 77% and NPV 96%. Otherwise, MIBG overall accuracy was 93%; sensitivity 77%; specificity 97%; VPP 78%; VPN 95%, considering DWIBS as gold standard. MIBG and WB MRI-DWIBS SIOPEN scoring resulted superimposable (Rho Spearman = 0,88, p < 0,0001).Conclusions: DWIBS and MIBG images showed very high concordance. WB MRI may represent an alternative in weak-avid MIBG tumors and for follow up assessment. An integrated imaging model is proposed for HR, Low and Intermediate Risk protocols.

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“…Significant difference was observed also for ∆ SI-DWI in nonresponders between the two field strengths. It is well established that T2w SI is associated with intracellular water content [ 19 – 21 ] and that a high T2w SI reflects tumor viability [ 22 ]. The progressive signal drop characterizing the T2w sequences during CRT and after the completion of neoadjuvant treatment can be explained by the successful treatment itself, which is responsible for a reduction of viable tissue and a concurrent increase of fibrosis [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance of Rectal Cancer Response to Therapy: An Image Quality Comparison between 3.0 and 1.5 Tesla

Zerunian

¹

,

Santis

²

,

Biondi

³

et al. 2020

BioMed Research International

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Purpose. To evaluate signal intensity (SI) differences between 3.0 T and 1.5 T on T2-weighted (T2w), diffusion-weighted imaging (DWI), and apparent diffusion coefficient (ADC) in rectal cancer pre-, during, and postneoadjuvant chemoradiotherapy (CRT). Materials and Methods. 22 patients with locally advanced rectal cancer were prospectively enrolled. All patients underwent T2w, DWI, and ADC pre-, during, and post-CRT on both 3.0 T MRI and 1.5 T MRI. A radiologist drew regions of interest (ROIs) of the tumor and obturator internus muscle on the selected slice to evaluate SI and relative SI (rSI). Additionally, a subanalysis evaluating the SI before and after-CRT (∆SI pre-post) in complete responder patients (CR) and nonresponder patients (NR) on T2w, DWI, and ADC was performed. Results. Significant differences were observed for T2w and DWI on 3.0 T MRI compared to 1.5 T MRI pre-, during, and post-CRT (all P < 0.001 ), whereas no significant differences were reported for ADC among all controls (all P > 0.05 ). rSI showed no significant differences in all the examinations for all sequences (all P > 0.05 ). ∆SI showed significant differences between 3.0 T and 1.5 T MRI for DWI-∆SI in CR and NR ( 188.39 ± 166.90 vs. 30.45 ± 21.73 and 169.70 ± 121.87 vs. 22.00 ± 31.29 , respectively, all P 0.02) and ADC-∆SI for CR ( − 0.58 ± 0.27 vs. − 0.21 ± 0.24 P value 0.02), while no significant differences were observed for ADC-∆SI in NR and both CR and NR for T2w-∆SI. Conclusion. T2w-SI and DWI-SI showed significant differences for 3.0 T compared to 1.5 T in all three controls, while ADCSI showed no significant differences in all three controls on both field strengths. rSI was comparable for 3.0 T and 1.5 T MRI in rectal cancer patients; therefore, rectal cancer patients can be assessed both at 3.0 T MRI and 1.5 T MRI. However, a significant DWI-∆SI and ADC-∆SI on 3.0 T in CR might be interpreted as a better visual assessment in discriminating response to therapy compared to 1.5 T. Further investigations should be performed to confirm future possible clinical application.

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Whole‐body MRI for metastatic cancer detection using T₂‐weighted imaging with fat and fluid suppression

Abstract: DETECT imaging technique generates T W images with high resolution, high SNR, minimal geometric distortions, and provides good lesion conspicuity with robust fat and fluid suppression in <7 min for whole-body imaging, demonstrating efficient and reliable metastatic cancer detection at 3T.

Cited by 9 publications

References 39 publications

Single‐shot RARE with Dixon: Application to robust abdominal imaging with uniform fat and water separation at 3T

Single‐shot RARE with Dixon: Application to robust abdominal imaging with uniform fat and water separation at 3T

Whole-Body MRI and Whole Body 123I-MIBG scintigraphy: comparison in Lines and High Risk Neuroblastoma. A pilot study.

Magnetic Resonance of Rectal Cancer Response to Therapy: An Image Quality Comparison between 3.0 and 1.5 Tesla

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Whole‐body MRI for metastatic cancer detection using T2‐weighted imaging with fat and fluid suppression

Abstract: DETECT imaging technique generates T W images with high resolution, high SNR, minimal geometric distortions, and provides good lesion conspicuity with robust fat and fluid suppression in <7 min for whole-body imaging, demonstrating efficient and reliable metastatic cancer detection at 3T.

Cited by 9 publications

References 39 publications

Single‐shot RARE with Dixon: Application to robust abdominal imaging with uniform fat and water separation at 3T

Single‐shot RARE with Dixon: Application to robust abdominal imaging with uniform fat and water separation at 3T

Whole-Body MRI and Whole Body 123I-MIBG scintigraphy: comparison in Lines and High Risk Neuroblastoma. A pilot study.

Magnetic Resonance of Rectal Cancer Response to Therapy: An Image Quality Comparison between 3.0 and 1.5 Tesla

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Product

Resources

About

Whole‐body MRI for metastatic cancer detection using T₂‐weighted imaging with fat and fluid suppression