2020
DOI: 10.21203/rs.3.rs-42436/v1
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Whole-brain irradiation differentially modifies neurotransmitters levels and receptors in the hypothalamus and the prefrontal cortex

Abstract: Background: Whole-brain radiotherapy is a primary treatment for brain tumors and brain metastasis, but it also induces long-term undesired effects. Since cognitive impairment can occur, research on the etiology of secondary effects has focused on the hippocampus. Often overlooked, the hypothalamus controls critical homeostatic functions, some of which are also susceptible after whole-brain radiotherapy. Therefore, using whole-brain irradiation in a rat model, we measured neurotransmitters and receptors in the … Show more

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“…The direction of change following radiation might depend on the type of radiation, brain region, and measure of GABA function assessed. Cortical GABA levels are reduced following combined irradiation with gamma rays and 12 C ions in Wistar rats (Kokhan et al, 2019), hypothalamic GABA levels are reduced following whole brain gamma irradiation while the GABA levels in the prefrontal cortex are not affected (Franco-Perez et al, 2020), but hippocampal GABA release is increased following proton irradiation (Lee et al, 2017).…”
Section: Discussionmentioning
confidence: 99%
“…The direction of change following radiation might depend on the type of radiation, brain region, and measure of GABA function assessed. Cortical GABA levels are reduced following combined irradiation with gamma rays and 12 C ions in Wistar rats (Kokhan et al, 2019), hypothalamic GABA levels are reduced following whole brain gamma irradiation while the GABA levels in the prefrontal cortex are not affected (Franco-Perez et al, 2020), but hippocampal GABA release is increased following proton irradiation (Lee et al, 2017).…”
Section: Discussionmentioning
confidence: 99%