Whole-brain mapping of venous vessel size in humans using the hypercapnia-induced BOLD effect

Jochimsen, Thies H.; Ivanov, Dimo; Ott, Derek V. M.; Heinke, Wolfgang; Turner, Robert; Möller, Harald E.; Reichenbach, Jürgen R.

doi:10.1016/j.neuroimage.2010.02.037

Cited by 40 publications

(55 citation statements)

References 54 publications

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“…The VSI we measured in the thalamus, where no large vessels present, is very similar to the value of 7.2 mm proposed by the microscale tissue model (Kiselev et al, 2005). Jochimsen et al (2010) assessed venous VSI in healthy human brains with the administration of carbogen by measuring the induced blood oxygenation level-dependent effect in a 7T scanner. Despite the different techniques, the vessel radii of GM and WM in our healthy volunteers are very similar to their venous vessel radii.…”

Section: Feasibility Of Vessel Size Imaging In Acute Strokesupporting

confidence: 76%

Vessel Size Imaging Reveals Pathological Changes of Microvessel Density and Size in Acute Ischemia

Schmidt

Villringer

et al. 2011

J Cereb Blood Flow Metab

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The aim of this study was to test the feasibility of vessel size imaging with precise evaluation of apparent diffusion coefficient and cerebral blood volume and to apply this novel technique in acute stroke patients within a pilot group to observe the microvascular responses in acute ischemic tissue. Microvessel density-related quantity Q and mean vessel size index (VSI) were assessed in 9 healthy volunteers and 13 acute stroke patients with vessel occlusion within 6 hours after symptom onset. Our results in healthy volunteers matched with general anatomical observations. Given the limitation of a small patient cohort, the median VSI in the ischemic area was higher than that in the mirrored region in the contralateral hemisphere (P < 0.05). Decreased Q was observed in the ischemic region in 2 patients, whereas no obvious changes of Q were found in the remaining 11 patients. In a patient without recanalization, the VSI hyperintensity in the subcortical area matched well with the final infarct. These data reveal that different observations of microvascular response in the acute ischemic tissue seem to emerge and vessel size imaging may provide useful information for the definition of ischemic penumbra and have an impact on future therapeutic approaches.

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Section: Feasibility Of Vessel Size Imaging In Acute Strokesupporting

confidence: 76%

Vessel Size Imaging Reveals Pathological Changes of Microvessel Density and Size in Acute Ischemia

Schmidt

Villringer

et al. 2011

J Cereb Blood Flow Metab

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“…Further discrepancies can be expected due to the differences in the vascular tone between living brain tissue and post-mortem specimen (Cassot et al, 2006). In a recent MRI study using hypercapnia-induced BOLD signal changes, Jochimsen et al (2010) reported r values of 13.4 ± 1.7 μm (GM) and 13.7 ± 2.1 μm (WM). Kiselev et al (2005) reported mean values ranging from 14.0-25.5 μm in grey matter and from 16.0-22.5 μm in white matter, using the paramagnetic contrast agent Gd-DTPA.…”

Section: Resultsmentioning

confidence: 99%

“…Techniques that use hypercapnia-induced BOLD signal changes exhibit a similar vascular specificity (Jochimsen et al, 2010), but the physiological effects of hypercapnia and hyperoxia are very different. While hyperoxia results in vasoconstriction, hypercapnia causes vasodilation.…”

Section: Discussionmentioning

confidence: 99%

“…The principle of this approach has been demonstrated in animal models using BOLD signal changes induced by hypoxia, hypercapnia or hyperoxia (Prinster et al, 1997;Lu et al, 2009), and more recently in humans using a visual stimulation task (Jochimsen and Möller, 2008) or hypercapnia (Jochimsen et al, 2010). While the first method is limited to activated brain regions, i.e.…”

Section: Introductionmentioning

confidence: 99%

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Magnetic resonance imaging of the mean venous vessel size in the human brain using transient hyperoxia

et al. 2011

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“…29 Using MRI, Jochimsen et al showed that vessel density in WM is about half of the density in GM and that the average vessel radius is about 13.5 mm in both GM and WM. 25 Using spin echo DSC, Helenius et al 30 reported a CBV of 1.3 ml/ 100 g tissue for WM and 4.6 ml/100 g tissue for GM, while Arakawa et al reported a CBV of 1.44 ml/100 g tissue for normal WM and 1.86 ml/100 g tissue for normal GM. 31 However, both studies did not report on potential anisotropy of WM vasculature.…”

Section: Discussionmentioning

confidence: 99%

Anisotropic cerebral vascular architecture causes orientation dependency in cerebral blood flow and volume measured with dynamic susceptibility contrast magnetic resonance imaging

Hernández‐Torres

Kassner

Forkert

et al. 2016

J Cereb Blood Flow Metab

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Measurements of cerebral perfusion using dynamic susceptibility contrast magnetic resonance imaging rely on the assumption of isotropic vascular architecture. However, a considerable fraction of vessels runs in parallel with white matter tracts. Here, we investigate the effects of tissue orientation on dynamic susceptibility contrast magnetic resonance imaging. Tissue orientation was measured using diffusion tensor imaging and dynamic susceptibility contrast was performed with gradient echo planar imaging. Perfusion parameters and the raw dynamic susceptibility contrast signals were correlated with tissue orientation. Additionally, numerical simulations were performed for a range of vascular volumes of both the isotropic vascular bed and anisotropic vessel components, as well as for a range of contrast agent concentrations. The effect of the contrast agent was much larger in white matter tissue perpendicular to the main magnetic field compared to white matter parallel to the main magnetic field. In addition, cerebral blood flow and cerebral blood volume were affected in the same way with angle-dependent variations of up to 130%. Mean transit time and time to maximum of the residual curve exhibited weak orientation dependency of 10%. Numerical simulations agreed with the measured data, showing that one-third of the white matter vascular volume is comprised of vessels running in parallel with the fibre tracts.

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Whole-brain mapping of venous vessel size in humans using the hypercapnia-induced BOLD effect

Cited by 40 publications

References 54 publications

Vessel Size Imaging Reveals Pathological Changes of Microvessel Density and Size in Acute Ischemia

Vessel Size Imaging Reveals Pathological Changes of Microvessel Density and Size in Acute Ischemia

Magnetic resonance imaging of the mean venous vessel size in the human brain using transient hyperoxia

Anisotropic cerebral vascular architecture causes orientation dependency in cerebral blood flow and volume measured with dynamic susceptibility contrast magnetic resonance imaging

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