Whole-brain R1 predicts manganese exposure and biological effects in welders

Edmondson, David; Yeh, Chien-Lin; Hélie, Sébastien; Dydak, Ulrike

doi:10.1007/s00204-020-02839-7

Cited by 12 publications

(2 citation statements)

References 37 publications

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“…However, another study did not observe any association between thalamic and striatal GABA levels and blood Mn or airborne metal exposure levels in welders [ 186 ]. This inconsistency may be explained by non-linear association between Mn exposure and brain GABA alterations, with the latter being undetectable at lower doses and periods of exposure [ 187 ].…”

Section: Neurotransmissionmentioning

confidence: 99%

Molecular Targets of Manganese-Induced Neurotoxicity: A Five-Year Update

Tinkov

Paoliello

Mazilina

et al. 2021

IJMS

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Understanding of the immediate mechanisms of Mn-induced neurotoxicity is rapidly evolving. We seek to provide a summary of recent findings in the field, with an emphasis to clarify existing gaps and future research directions. We provide, here, a brief review of pertinent discoveries related to Mn-induced neurotoxicity research from the last five years. Significant progress was achieved in understanding the role of Mn transporters, such as SLC39A14, SLC39A8, and SLC30A10, in the regulation of systemic and brain manganese handling. Genetic analysis identified multiple metabolic pathways that could be considered as Mn neurotoxicity targets, including oxidative stress, endoplasmic reticulum stress, apoptosis, neuroinflammation, cell signaling pathways, and interference with neurotransmitter metabolism, to name a few. Recent findings have also demonstrated the impact of Mn exposure on transcriptional regulation of these pathways. There is a significant role of autophagy as a protective mechanism against cytotoxic Mn neurotoxicity, yet also a role for Mn to induce autophagic flux itself and autophagic dysfunction under conditions of decreased Mn bioavailability. This ambivalent role may be at the crossroad of mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis. Yet very recent evidence suggests Mn can have toxic impacts below the no observed adverse effect of Mn-induced mitochondrial dysfunction. The impact of Mn exposure on supramolecular complexes SNARE and NLRP3 inflammasome greatly contributes to Mn-induced synaptic dysfunction and neuroinflammation, respectively. The aforementioned effects might be at least partially mediated by the impact of Mn on α-synuclein accumulation. In addition to Mn-induced synaptic dysfunction, impaired neurotransmission is shown to be mediated by the effects of Mn on neurotransmitter systems and their complex interplay. Although multiple novel mechanisms have been highlighted, additional studies are required to identify the critical targets of Mn-induced neurotoxicity.

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Section: Neurotransmissionmentioning

confidence: 99%

Molecular Targets of Manganese-Induced Neurotoxicity: A Five-Year Update

Tinkov

Paoliello

Mazilina

et al. 2021

IJMS

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“…Currently, the signal intensity on a T1-weighted MRI for the globus pallidus, caudate and putamen and pallidal index is the most reliable MRI-related biomarker for the diagnosis of manganese toxicity [24]. The T1-weighted basal ganglia signals and pallidal index are associated with occupational Mn exposure and the severity of Parkinsonism in steelworkers, miners and welders [25][26][27]. However, these MRI abnormalities are not directly related to the symptoms of manganism, as they can also occur in asymptomatic welders [28].…”

Section: Factory Workers Miners and Weldersmentioning

confidence: 99%

Magnetic Resonance Imaging and Manganism: A Narrative Review and Laboratory Recommendations

Majewski,

Piwko,

Ordak

et al. 2024

JCM

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In recent years, a series of articles has been published concerning magnetic resonance imaging (MRI) studies in a group of patients exposed to manganism, specifically factory workers, welders, and individuals with liver diseases, as well as those abusing home-produced ephedrone. Some potential symptoms of manganese toxicity include motor disturbances, neurocognitive problems, sleep disorders, and psychosocial changes. Despite various publications on MRI research in individuals with an elevated risk of manganism, there is a noticeable absence of a comprehensive review in this field. The detection of the accumulation of manganese in the brain through MRI can confirm the diagnosis and guide appropriate treatment. Due to the high cost of determining manganese ion levels in biological material, an additional aim of the manuscript was to identify simple medical laboratory parameters that, when performed concurrently with MRI, could assist in the diagnosis of manganism. Among these types of parameters are the levels of bilirubin, magnesium, liver enzymes, creatinine, hemoglobin, and hematocrit.

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Neurotoxicology and Behavior

Boyes

2023

Patty's Toxicology

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Neurotoxicity is important to consider as a component of occupational and environmental safety and health programs. The failure to do so has contributed to a number of tragic cases in which people were irreparably harmed by exposure to compounds that proved toxic to the nervous system. The field of neurotoxicology originated in response to several episodes of mass poisoning and developed through advances in clinical practice, scientific research, and regulatory actions. This chapter reviews broadly the development of the field of neurotoxicity and discusses some of the predominant current issues. The chapter includes consideration of the features of the nervous system that make it susceptible to toxicity, the response to injury, the evaluation of sensory, cognitive, and motor functions, and effects on emotionality, mood, and social conduct. An emphasis is placed on functional outcomes that may be especially important in occupational and industrial hygiene settings. There is increasingly an emphasis on potential toxic effects on neurodevelopment and contributions to neurodegenerative diseases. Also, there is a large and growing effort to develop more rapid and cost‐efficient screening tests for potential neurotoxicity. A brief overview of some of the major classes of neurotoxic substances is provided including metals, solvents, pesticides, persistent organic compounds, and air pollution. Finally, the need for programs to prevent neurotoxic illness is discussed.

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Whole-brain R1 predicts manganese exposure and biological effects in welders

Cited by 12 publications

References 37 publications

Molecular Targets of Manganese-Induced Neurotoxicity: A Five-Year Update

Molecular Targets of Manganese-Induced Neurotoxicity: A Five-Year Update

Magnetic Resonance Imaging and Manganism: A Narrative Review and Laboratory Recommendations

Neurotoxicology and Behavior

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