Whole Brain Radiation Therapy (WBRT) with Simultaneous Integrated Boost (SIB) to Brain Metastasis via Image Guided, Intensity Modulated Radiation Therapy (IG-IMRT): Dosimetric and Early Clinical Experience

Clark, Grant M.; Plants, B; Mallah, J; Raja, P; Farinash, L; Harmon, M; Whaley, L; Mihailidis, Dimitris

doi:10.1016/j.ijrobp.2008.06.624

Cited by 5 publications

(3 citation statements)

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“…The use of WBRT with simultaneous integrated boost (SIB) for brain metastases has been accomplished with image-guided intensity modulated radiotherapy (IMRT) and with helical tomotherapy (10,11). More recently, the feasibility of delivering WBRT with hippocampal avoidance and SIB for brain metastases has been reported using tomotherapy (5,7).…”

Section: Introductionmentioning

confidence: 99%

Whole Brain Radiotherapy With Hippocampal Avoidance and Simultaneous Integrated Boost for 1–3 Brain Metastases: A Feasibility Study Using Volumetric Modulated Arc Therapy

Hsu

Carolan

Nichol

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

110

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Section: Introductionmentioning

confidence: 99%

Whole Brain Radiotherapy With Hippocampal Avoidance and Simultaneous Integrated Boost for 1–3 Brain Metastases: A Feasibility Study Using Volumetric Modulated Arc Therapy

Hsu

Carolan

Nichol

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

110

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“…The studies used in this review demonstrated that VMAT treatment times were superior to those of the reported IMRT times which ranged from 2.79 to 30 min 11,21. Comparable results were identified in regard to the toxicities incurred by the two techniques, with both techniques only reporting minimal toxicities of alopecia and dermatitis1,13,14,21 Local control and survival rates reported in the IMRT studies were similar to the VMAT rates, with IMRT local control ranging from 59% to 72% and the median overall survival ranging from 2 to 13 months 20–22. Future studies should compare the ability of VMAT treatment to spare critical structures in comparison to IMRT treatment so that accurate toxicity data can be obtained.…”

Section: Discussionmentioning

confidence: 89%

The feasibility and benefits of using volumetric arc therapy in patients with brain metastases: a systematic review

Andrevska

Knight

Sale

2014

J of Medical Radiation Sci

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IntroductionRadiotherapy management of patients with brain metastases most commonly involve a whole-brain radiation therapy (WBRT) regime, as well as newer techniques such as stereotactic radiosurgery (SRS) and intensity modulated radiotherapy (IMRT). The long treatment times incurred by these techniques indicates the need for a novel technique that has shorter treatment times, whilst still producing highly conformal treatment with the potential to deliver escalated doses to the target area. Volumetric modulated arc therapy (VMAT) is a dynamic, highly conformal technique that may deliver high doses of radiation through a single gantry arc and reduce overall treatment times. The aim of this systematic review is to determine the feasibility and benefits of VMAT treatment in regard to overall survival rates and local control in patients with brain metastases, in comparison with patients treated with WBRT, SRS and IMRT.MethodsA search of the literature identified 23 articles for the purpose of this review. Articles were included on the basis they were human-based studies, with sample sizes of more than five patients who were receiving treatment for 1–10 metastatic brain lesions.ResultsVMAT was found to be highly conformal, have a reduced treatment delivery time and incurred no significant toxicities in comparison with WBRT, SRS and IMRT.ConclusionCompared to other treatment techniques, VMAT proved to have fewer toxicities than conventional WBRT, shorter treatment times than SRS and similar dose distributions to IMRT plans. Future prospective studies are needed to accurately assess the prognostic benefits of VMAT as well as the occurrence of late toxicities.

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“…Such high doses may result in a substantially greater risk of gastrointestinal toxicity, particularly stemming from the rectal dose and bladder hematuria. Radiation doses to the prostate should be better set to reduce possible complications of normal tissue [3].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Treatment Plan Quality between Magnetic Resonance-Guided Radiotherapy and Volumetric Modulated Arc Therapy for Prostate Cancer

Choi

Kim

Son

et al. 2022

Progress in Medical Physics

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This study evaluated the quality of plans based on magnetic resonance-guided radiotherapy (MRgRT) tri-Co-60, linac, and conventional linac-based volumetric modulated arc therapy (linac-VMAT) for prostate cancer.Methods: Twenty patients suffering from prostate cancer with intermediate risk who were treated by MAT were selected. Additional treatment plans (primary and boost plans) were generated based on MRgRT-tri-Co-60 and MRgRT-linac. The planning target volume (PTV) of MRgRT-based plans was created by adding a 3 mm margin from the clinical target volume (CTV) due to high soft-tissue contrast and real-time motion imaging. On the other hand, the PTV of conventional linac was generated based on a 1 cm margin from CTV. The targets of primary and boost plans were prostate plus seminal vesicle and prostate only, respectively. All plans were normalized to cover 95% of the target volume by 100% of the prescribed dose. Dosimetric characteristics were evaluated for each of the primary, boost, and sum plans.Results: For target coverage and conformity, the three plans showed similar results. In the sum plans, the average value of V 65Gy of the rectum of MRgRT-linac (2.62%±2.21%) was smaller than those of MRgRT tri-Co-60 (9.04%±3.01%) and linac-VMAT (9.73%±7.14%) (P<0.001). In the case of bladder, the average value of V 65Gy of MRgRT-linac was also smaller. Conclusions:In terms of organs at risk sparing, MRgRT-linac shows the best value while maintaining comparable target coverage among the three plans.

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Whole Brain Radiation Therapy (WBRT) with Simultaneous Integrated Boost (SIB) to Brain Metastasis via Image Guided, Intensity Modulated Radiation Therapy (IG-IMRT): Dosimetric and Early Clinical Experience

Cited by 5 publications

References 0 publications

Whole Brain Radiotherapy With Hippocampal Avoidance and Simultaneous Integrated Boost for 1–3 Brain Metastases: A Feasibility Study Using Volumetric Modulated Arc Therapy

Whole Brain Radiotherapy With Hippocampal Avoidance and Simultaneous Integrated Boost for 1–3 Brain Metastases: A Feasibility Study Using Volumetric Modulated Arc Therapy

The feasibility and benefits of using volumetric arc therapy in patients with brain metastases: a systematic review

Evaluation of Treatment Plan Quality between Magnetic Resonance-Guided Radiotherapy and Volumetric Modulated Arc Therapy for Prostate Cancer

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