Whole-breast radiotherapy with shorter fractionation schedules following breast-conserving surgery: short-term morbidity and preliminary outcomes

Fujii, Osamu; Hiratsuka, Jyunichi; Nagase, Naomi; Tokiya, Ryuji; Yoden, Eisaku; Sonoo, Hiroshi; Murashima, Nobutaka; Iha, Shigemichi; Imajyo, Yoshinari

doi:10.1007/s12282-007-0010-3

Cited by 17 publications

(27 citation statements)

References 30 publications

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“…Fujii et al [23] reported acceptable results in terms of local control and toxicity (although the median follow-up of this study was 26 mo) with a short fractionation schedule of 42.5-47.8 Gy/16-20 fractions. In another study from the University of Florence, Italy, Livi et al [26] reported similar results in 539 patients.…”

Section: Review Of Clinical Studiesmentioning

confidence: 58%

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Hypofractionated radiotherapy in the treatment of early breast cancer

Plataniotis

2010

WJR

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Radiotherapy (RT) after tumorectomy in early breast cancer patients is an established treatment modality which conventionally takes 6-7 wk to complete. Shorter RT schedules have been tested in large multicentre randomized trials and have shown equivalent results to that of standard RT (50 Gy in 25 fractions) in terms of local tumor control, patient survival and late post-radiation effects. Some of those trials have now completed 10 years of follow-up with encouraging results for treatments of 3-4 wk and a total RT dose to the breast of 40-42.5 Gy with or without boost. A reduction of 50% in treatment time makes those RT schedules attractive for both patients and health care providers and would have a significant impact on daily RT practice around the world, as it would accelerate patient turnover and save health care resources. However, in hypofractionated RT, a higher (than the conventional 1.8-2 Gy) dose per fraction is given and should be managed with caution as it could result in a higher rate of late postradiation effects in breast, heart, lungs and the brachial plexus. It is therefore advisable that both possible dose inhomogeneity and normal tissue protection should be taken into account and the appropriate technology such as three-dimensional/intensity modulated radiation therapy employed in clinical practice, when hypofractionation is used.

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Section: Review Of Clinical Studiesmentioning

confidence: 58%

“…Clinical reports from various centres have shown almost equivalent results between short and standard RT schedules [9][10][11][18][19][20][21][22][23][24][25][26][27] , and it would be interesting to have an overview of the current situation in this field.…”

Section: Review Of Clinical Studiesmentioning

confidence: 99%

Hypofractionated radiotherapy in the treatment of early breast cancer

Plataniotis

2010

WJR

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“…Ten Japanese epidemiological studies were identified [15][16][17][18][19][20][21][22][23][24]. Several studies were from a single institution [16,17,20,21,23,24], and one study was a survey among 20 institutions (Table 1) [18].…”

Section: Resultsmentioning

confidence: 99%

“…Several studies were from a single institution [16,17,20,21,23,24], and one study was a survey among 20 institutions (Table 1) [18]. These reports described BOOP occurring in 129 of 7,671 women (1.7%), and studies showed a range of prevalence from 0.8% to 2.9% [15][16][17][18][19][20][21][22][23][24]. Five of the 9 reports showed patients received a traditional whole-breast irradiation protocol of 50 Gy in 25 fractions [19][20][21]23, 24], 1 report showed 248 patients received hypofractionated whole-breast radiotherapy [17], 1 report included patients who received whole-breast irradiation or accelerated hyperfractionated whole-breast irradiation [15], and there was no information about the radiation protocol for 3 reports.…”

Section: Resultsmentioning

confidence: 99%

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Systematic Review of Postradiotherapy Bronchiolitis Obliterans Organizing Pneumonia in Women With Breast Cancer

Epler

Kelly

2014

The Oncologist

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Background. Radiation therapy for breast cancer has been implicated in the development of bronchiolitis obliterans organizing pneumonia (BOOP).This inflammatory lung disorder was first noted in 1983, and there have been numerous reports of BOOPoccurring in womenwho have had radiation therapy for breast cancer since 1995.This study was undertaken to perform a systematic review of postradiotherapy BOOP to determine the occurrence, presentation, treatment, and outcome. Materials and Methods. A systematic literature review was conducted according to the guidelines provided by the Preferred ReportingItemsforSystematicReviewsandMeta-Analysesreport. Results. The literature search yielded 10 Japanese epidemiological reports with 129 women, 4 case series reports with 36

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Oral curcumin for radiation dermatitis: a URCC NCORP study of 686 breast cancer patients

Wolf

Heckler

Guido

et al. 2017

Support Care Cancer

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Whole-breast radiotherapy with shorter fractionation schedules following breast-conserving surgery: short-term morbidity and preliminary outcomes

Abstract: The short fractionation regimen results in acceptable short-term morbidity. With limited follow-up, the incidence of recurrence in the treated breast was low.

Cited by 17 publications

References 30 publications

Hypofractionated radiotherapy in the treatment of early breast cancer

Hypofractionated radiotherapy in the treatment of early breast cancer

Systematic Review of Postradiotherapy Bronchiolitis Obliterans Organizing Pneumonia in Women With Breast Cancer

Oral curcumin for radiation dermatitis: a URCC NCORP study of 686 breast cancer patients

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