Whole-genome DNA methylation in skin lesions from patients with psoriasis vulgaris

Genetic, Epigenetic and Pharmacogenetic Aspects of Psoriasis and Psoriatic Arthritis

“…130 MeDIP-Seq has revealed a much greater number of hypermethylated DMRs in the affected skin of psoriatic patients, including in genes enriched for the immune system, cell cycle regulation, and apoptotic mechanisms. 131 The MeDIP-Seq results for methylation status of PDCD5 and TIMP2 were confirmed and the messenger RNA expression levels of these 2 genes were consistent with their DNA methylation profiles. 131 Likewise, MeDIP-Seq of CD4 1 T cells from psoriatic patients revealed global DNA hypermethylation compared with healthy controls, and hypermethylated regions were enriched in gene promoters.…”

Epigenetic Downregulation of SFRP4 Contributes to Epidermal Hyperplasia in Psoriasis

“…Several studies suggested that DNA methylation may be involved in the pathogenesis of psoriasis (23,35). To investigate whether aberrant CpG island methylation of SFRP4 exists in lesional skin of patients with psoriasis, we used bisulfite genomic next-generation sequencing on DNA samples derived from normal and psoriatic skin.…”

“…DNA methylation, a critical epigenetic modification of the genome, is involved in the regulation of several developmental and cellular processes, including transcription, embryonic development, X-chromosome inactivation, chromosome stability, and genomic imprinting (22). Using methylated DNA immunoprecipitation sequencing, the whole-genome DNA methylation patterns in involved and uninvolved skin lesions from patients with psoriasis were characterized recently, suggesting that DNA methylation might act in an epigenetic dysregulation of biological pathways in psoriasis (23). The aim of the current study was to investigate whether the Wnt antagonist SFRP4 is functionally involved in the hyperproliferation of epidermis, as well as the upstream epigenetic mechanisms responsible for the downregulation of SFRP4 in psoriasis.…”

Genetics of Psoriasis

“…Preliminary data reveal a potential role for epigenetic factors in the pathogenesis of psoriasis. [85][86][87] Finally, the lead SNP found in association studies may not be the causal SNP, and it may be an imperfect proxy for the causal SNP. By virtue of nextgeneration sequencing, SNP arrays have become denser, hence the lead SNP found in future association studies may be a more accurate proxy for the causal SNP and the effect size estimated will be more accurate.…”