Whole-genome metagenomic analysis of the oral microbiota in patients with obstructive sleep apnea

Gao, Yu; Wang, Huanhuan; HU, Yazhuo; Li, Jianhua; Xu, Weihao; Zhao, Lianbi; Su, Xiaojing; Han, Jianbo; Li, Tianzhi; Fang, Xiangqun; Liu, Lin

doi:10.1007/s11325-022-02732-w

Cited by 2 publications

(3 citation statements)

References 39 publications

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“…Streptococcus was related to tonsil and adenoid hypertrophy, and previous metagenomics studies had also found that, compared with the control group, the abundance of Streptococcus in the oral mucosa of OSA patients was increased. 9 Higher abundance levels of Streptococcus were also found in the nasal passages of adult OSA patients. 47 With the increased abundance of Streptococcus in the oral cavity, its metabolites could directly or indirectly upregulate the level of inflammatory factors in oropharyngeal tissues, causing inflammatory distention of the soft palate, tonsils, and adenoids.…”

Section: Discussionmentioning

confidence: 95%

“…However, studies on the changes in oral microbial diversity in OSA patients have shown inconsistent results. Some studies indicated that OSA patients have lower α-diversity than that of healthy controls, 5 , 9 , 34 although some studies shown no difference, 7 , 35–37 and another study found higher α-diversity in the OSA group. 38 We hypothesize that this was because the severity of OSA was different and the sample of patients was sampled at different sites of the oral cavity, leading to different results.…”

Section: Discussionmentioning

confidence: 99%

“… 5 The OSA patients have higher relative abundances of Porphyromonas and Aggregatibacter in oral compared with individuals without OSA reported by Chih-Yuan Ko et al 7 In another study analyzed of oral microbiota in OSA patients with whole-genome metagenomic, the results showed that at the species level, the relative abundances of Prevotella, Alloprevotella, Bacteroides, Veillonella_tobetsuensis, Candidatus saccharimonas , and Leptotrichia in the groups with severe OSA were significantly lower than those in the healthy controls. 9 …”

Section: Introductionmentioning

confidence: 99%

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Whole-Genome Metagenomic Analysis of the Oral Microbiota in Patients with Obstructive Sleep Apnea Comorbid with Major Depressive Disorder

Ye,

Lv,

Xie

et al. 2024

NSS

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Background Obstructive sleep apnea (OSA) patients commonly experience high rates of depression. This study aims to examine the oral microbiota characteristics of OSA and those with comorbid major depressive disorder (OSA+MDD) patients. Methods Participants were enrolled from Aug 2022 to Apr 2023. Polysomnography, psychiatrist interviews, and scales were used to diagnose OSA and MDD. Oral samples were collected from participants by rubbing swabs on buccal mucosa, palate, and gums. Oral microbiota was analyzed via whole-genome metagenomics and bioinformatic analysis followed sequencing. Venous blood was drawn to detect plasma inflammatory factor levels. Results The study enrolled 33 OSA patients, 28 OSA+MDD patients, and 28 healthy controls. Significant differences were found in 8 phyla, 229 genera, and 700 species of oral microbiota among the three groups. Prevotellaceae abundance in the OSA and OSA+MDD groups was significantly lower than that in healthy controls. Linear discriminant analysis effect size (LEfSe) analysis showed that Streptococcaceae and Actinobacteria were the characteristic oral microbiota of the OSA and OSA+MDD groups, respectively. KEGG analysis indicates 30 pathways were changed in the OSA and OSA+MDD groups compared with healthy controls, and 23 pathways were changed in the OSA group compared with the OSA+MDD group. Levels of IL-6 in the OSA+MDD group were significantly higher than in the healthy group, correlating positively with the abundance of Schaalia, Campylobacter, Fusobacterium, Alloprevotella, and Candidatus Nanosynbacter in the oral, as well as with Hamilton Anxiety Rating Scale and Hamilton Depression Rating Scale scores. Conclusion Significant differences in oral microbiota populations and gene function were observed among the three groups. OSA patients were characterized by a decreased abundance of Prevotellaceae and an increased abundance of Streptococcaceae. OSA+MDD patients had an increased abundance of Actinobacteria. IL-6 might regulate the relationship between depression and the oral microbiota in OSA+MDD patients.

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Section: Discussionmentioning

confidence: 95%