2021
DOI: 10.1101/2021.09.27.21264209
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Whole genome sequence analysis of Salmonella Typhi in Papua New Guinea reveals an established population of genotype 2.1.7 sensitive to antimicrobials

Abstract: Background: Typhoid fever, a systemic infection caused by Salmonella enterica serovar Typhi, remains a considerable public health threat in impoverished regions within many low- and middle-income settings. However, we still lack a detailed understanding of the emergence, population structure, molecular mechanisms of antimicrobial resistance (AMR), and transmission dynamics of S. Typhi across many settings, particularly throughout the Asia-Pacific islands. Here we present a comprehensive whole genome sequence (… Show more

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“…These isolates differed by a median of 8 SNPs in the core genome. For context, the average core genome mutation rate in S. Typhi is approximately 1 substitution/genome/year every year [21,[43][44][45]. As such, it is unlikely that these isolates originated from a clonal source and sequentially acquired this genetic variation in <2 years.…”
Section: Smentioning
confidence: 99%
“…These isolates differed by a median of 8 SNPs in the core genome. For context, the average core genome mutation rate in S. Typhi is approximately 1 substitution/genome/year every year [21,[43][44][45]. As such, it is unlikely that these isolates originated from a clonal source and sequentially acquired this genetic variation in <2 years.…”
Section: Smentioning
confidence: 99%