Whole genome sequencing of 10K patients with acute ischaemic stroke or transient ischaemic attack: design, methods and baseline patient characteristics

Cheng, Si; Xu, Zhe; Liu, Yang; Lin, Jinxi; Jiang, Yong; Wang, Yilong; Meng, Xia; Wang, Anxin; Huang, Xin; Wang, Zhimin; Chen, Guohua; Wu, Songdi; Jia, Zhengchang; Chen, Yongming; Qiu, Xuerong; Wu, Jun; Song, Binbin; Ji, Weizhong; An, Zhuoling; Wang, Handong; Zhao, Lili; Yang, Geng; Li, Hongyan; Li, Hao; Wang, Yongjun

doi:10.1136/svn-2020-000664

Cited by 24 publications

(33 citation statements)

References 77 publications

(68 reference statements)

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“…Both ischemic and hemorrhagic [ 109 ] strokes have been observed in patients with COVID-19 and are more likely to be seen in individuals experiencing a more severe course of disease, with cardiovascular disease (CVD) risk factors (e.g., hypertension, diabetes, and history of CVD), increased inflammatory response, and hypercoagulable state (as reflected in CRP and D-dimer levels) [ 99 , 100 , 110 ]. A cohort study in the NYU Langone Health system noted a mean age of 61.6 years for COVID-19-positive patients with intracranial hemorrhage [ 109 ], and a systematic review found a mean age of 63.4 for acute ischemic stroke [ 111 ].…”

Section: Acute Cns Symptoms In Covid-19mentioning

confidence: 99%

“…The occurrence of ischemic strokes [ 99 , 100 , 110 ] as well as the predominance of vascular neuropathlogic findings (i.e., microthrombi, acute infarction) found in autopsies [ 77 ] of individuals with COVID-19 are significant causes of concern for potential morbidity and mortality. This leads to the question—are there hemostatic abnormalities induced in SARS-CoV-2 infection?…”

Section: Acute Clotting Disorders In Covid-19mentioning

confidence: 99%

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Biological and Psychological Factors Determining Neuropsychiatric Outcomes in COVID-19

Tizenberg

Brenner

Lowry

et al. 2021

Curr Psychiatry Rep

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Purpose of Review We present biological and psychological factors implicated in psychiatric manifestations of SARS-CoV-2, as well as its neuroinvasive capability and immune pathophysiology. Recent Findings Preexisting mental illness leads to worse clinical outcomes in COVID-19. The presence of the virus was reported in the cerebrospinal fluid (CSF) and brain tissue post-mortem. Most common psychiatric manifestations include delirium, mood disorders, anxiety disorders, and posttraumatic stress disorder. “Long-COVID” non-syndromal presentations include “brain-fogginess,” autonomic instability, fatigue, and insomnia. Summary SARS-CoV-2 infection can trigger prior vulnerabilities based on the priming of microglia and other cells, induced or perpetuated by aging and mental and physical illnesses. COVID-19 could further induce priming of neuroimmunological substrates leading to exacerbated immune response and autoimmunity targeting structures in the central nervous system (CNS), in response to minor immune activating environmental exposures, including stress, minor infections, allergens, pollutants, and traumatic brain injury.

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Section: Acute Cns Symptoms In Covid-19mentioning

confidence: 99%

Section: Acute Clotting Disorders In Covid-19mentioning

confidence: 99%

Biological and Psychological Factors Determining Neuropsychiatric Outcomes in COVID-19

Tizenberg

Brenner

Lowry

et al. 2021

Curr Psychiatry Rep

View full text Add to dashboard Cite

show abstract

“…[ 11 ] Among the 219 COVID-19 patients, COVID-19 patients with cerebrovascular disease are significantly older, are more likely to develop into severe COVID-19 and may have cardiovascular risk factors, including a history of hypertension and diabetes. [ 102 ] In a case study of SARS-CoV-2 infection, there were more male patients than females. In addition, about half of infected patients suffered from chronic underlying diseases, mainly cardiovascular and cerebrovascular diseases and diabetes.…”

Section: Endothelial Dysfunction: a Collision Of Thromboinflammation Cytokine Storm And Ace2 Downregulationmentioning

confidence: 99%

A review of ischemic stroke in COVID-19: currently known pathophysiological mechanisms

Tang

Zheng

2021

Neurol Sci

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Coronavirus disease 2019 (COVID-19), the third type of coronavirus pneumonia after severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), is spreading widely worldwide now. This pneumonia causes not only respiratory symptoms but also multiple organ dysfunction, including thrombotic diseases such as ischemic stroke. The purpose of this review is to explore whether COVID-19 is a risk factor for ischemic stroke and its related pathophysiological mechanisms. Based on the high thrombosis rate and frequent strokes of COVID-19 patients, combined with related laboratory indicators and pathological results, the discussion is mainly from two aspects: nerve invasion and endothelial dysfunction. SARS-CoV-2 can directly invade the CNS through blood-borne and neuronal retrograde pathways, causing cerebrovascular diseases. In addition, the endothelial dysfunction in COVID-19 is almost certain. Cytokine storm causes thromboinflammation, and downregulation of ACE2 leads to RAS imbalance, which eventually lead to ischemic stroke.

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“…Monocyte activation is postulated to constitute part of the secondary hemophagocytic lymphohistiocytosis described in severe COVID-19 [ 41 ]. Thrombocytopenia with elevated d -dimer and C-reactive protein in severe COVID-19 and stroke is consistent with a virus-associated microangiopathic process [ 42 ]. Higher production of anti-cardiolipin and anti-β2GP1 antibodies has been also reported in patients with COVID-19 [ 43 ].…”

Section: Sars‐cov‐2: Neurovirulence and Central Nervous System Entry Routesmentioning

confidence: 99%

Neurological Implications of COVID-19: Role of Redox Imbalance and Mitochondrial Dysfunction

2021

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Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 or COVID-19 has been declared as a pandemic disease by the World Health Organization (WHO). Globally, this disease affected 159 million of the population and reported ~ 3.3 million deaths to the current date (May 2021). There is no definitive treatment strategy that has been identified, although this disease has prevailed in its current form for the past 18 months. The main challenges in the (SARS-CoV)-2 infections are in identifying the heterogeneity in viral strains and the plausible mechanisms of viral infection to human tissues. In parallel to the investigations into the patho-mechanism of SARS-CoV-2 infection, understanding the fundamental processes underlying the clinical manifestations of COVID-19 is very crucial for designing effective therapies. Since neurological symptoms are very apparent in COVID-19 infected patients, here, we tried to emphasize the involvement of redox imbalance and subsequent mitochondrial dysfunction in the progression of the COVID-19 infection. It has been articulated that mitochondrial dysfunction is very apparent and also interlinked to neurological symptoms in COVID-19 infection. Overall, this article provides an in-depth overview of redox imbalance and mitochondrial dysfunction involvement in aggravating COVID-19 infection and its probable contribution to the neurological manifestation of the disease.

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Whole genome sequencing of 10K patients with acute ischaemic stroke or transient ischaemic attack: design, methods and baseline patient characteristics

Cited by 24 publications

References 77 publications

Biological and Psychological Factors Determining Neuropsychiatric Outcomes in COVID-19

Biological and Psychological Factors Determining Neuropsychiatric Outcomes in COVID-19

A review of ischemic stroke in COVID-19: currently known pathophysiological mechanisms

Neurological Implications of COVID-19: Role of Redox Imbalance and Mitochondrial Dysfunction

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