Whole Genome Sequencing of First Janibacter indicus Isolate in China Revealed Three Unique Genomic Islands Compared with Saprophytic Strains

Zhang, Min; Wang, Ziwen; Liang, Zhenshan; Hu, Nan

doi:10.2147/idr.s341591

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…ATP-binding cassette (ABC) transporters facilitate the movement of various substrates across cell membrane by ATP binding, hydrolysis, and phosphate release [39][40][41]. FbpABC, an ABC transporter system for iron uptake, enables bacteria to transport iron ions into their cells, which is crucial for in vivo proliferation [42][43][44][45][46]. We hypothesize that these virulence factors serve diverse roles in the movement, adhesion, and biofilm formation of Flavonifractor plautii.…”

Section: Discussionmentioning

confidence: 99%

Genome Sequencing Analysis of a Rare Case of Blood Infection Caused by Flavonifractor plautii

Chen,

Bi,

Ruan

et al. 2024

Am J Case Rep

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Objective:Rare disease Background:Flavonifractor plautii belongs to the clostridium family, which can lead to local infections as well as the bloodstream infections. Flavonifractor plautii caused infection is rarely few in the clinic. To understand better Flavonifractor plautii, we investigated the drug sensitivity and perform genome sequencing of Flavonifractor plautii isolated from blood samples in China and explored the drug resistance and pathogenic mechanism of the bacteria. Case report:The Epsilometer test method was used to detect the sensitivity of flavonoid bacteria to antimicrobial agents. PacBio sequencing technology was employed to sequence the whole genome of Flavonifractor plautii, and gene prediction and functional annotation were also analyzed. Flavonifractor plautii displayed sensitivity to most drugs but resistance to fluoroquinolones and tetracycline, potentially mediated by tet (W/N/W). The total genome size of Flavonifractor plautii was 4,573,303 bp, and the GC content was 59.78%. Genome prediction identified 4,506 open reading frames, including 9 ribosomal RNAs and 66 transfer RNAs. It was detected that the main virulence factor-coding genes of the bacteria were the capsule, polar flagella and FbpABC, which may be associated with bacterial movement, adhesion, and biofilm formation. Conclusions:The results of whole-genome sequencing could provide relevant information about the drug resistance mechanism and pathogenic mechanism of bacteria and offer a basis for clinical diagnosis and treatment.

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Section: Discussionmentioning

confidence: 99%

Genome Sequencing Analysis of a Rare Case of Blood Infection Caused by Flavonifractor plautii

Chen,

Bi,

Ruan

et al. 2024

Am J Case Rep

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“…While Janibacter is one of the most prevalent bacterial taxa on the skin [ 23 ], its specific biological functions in human health are yet to be established. The genus Janibacter consists of nine different species, which are mainly found in the environment but, rarely, invasive infections by Janibacter have been reported in humans [ 24 , 25 , 26 ], mostly through identification using 16S rRNA gene sequencing. No studies have linked Janibacter to skin infections or cutaneous inflammation.…”

Section: Discussionmentioning

confidence: 99%

Early-Life Skin Microbial Biomarkers for Eczema Phenotypes in Chinese Toddlers

et al. 2023

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Eczema is a common inflammatory skin disorder during infancy. Evidence has shown that skin-microbiome fluctuations may precede eczema development, but their predictive value for eczema phenotypes remains unknown. We aimed to investigate the early-life evolution of the skin microbiome and its temporal associations with different pairs of eczema phenotypes (transient versus persistent, atopic versus non-atopic) in Chinese children. We followed 119 term Chinese infants from birth to 24 months old within a Hong Kong birth cohort. The skin microbes at the left antecubital fossa were serially sampled by flocked swabs at 1, 6, and 12 months for bacterial 16S rRNA gene sequencing. The atopic sensitization at 12 months was strongly associated with eczema persisting to 24 months (odds ratio 4.95, 95% confidence interval 1.29–19.01). Compared with those with non-atopic eczema, the children with atopic eczema had reduced alpha diversity at 12 months (p < 0.001) and transiently higher abundance of the genus Janibacter at 6 months (p < 0.001). Our findings suggest that atopic sensitization at 12 months may predict persistent eczema by 24 months, and atopic eczema at 12 months is associated with unique skin microbiome profiles at 6 and 12 months. Non-invasive skin-microbiome profiling may have predictive value for atopic eczema.

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Coryneform Gram‐Positive Rods

Mattos‐Guaraldi,

Santos,

Vieira

2023

ClinMicroNow

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This chapter presents Coryneform bacteria comprising aerobically or facultatively anaerobically growing, asporogenous, non‐acid fast Gram‐positive rods with irregular morphology. Establishing the clinical significance of coryneform bacteria can be difficult for caregivers and microbiologists. Corynebacterium spp. form the predominant group and include diphtheria toxin (DT)‐producing Corynebacterium diphtheriae , the causative agent of classic diphtheria, which was once a major cause of illness and death among children. Laboratory procedures for identification of Corynebacterium spp. and other coryneform bacteria include collection and transport of clinical samples, isolation practices, culture conditions, phenotypic and molecular assays, as well as antimicrobial susceptibility testing. Molecular techniques have been increasingly used in microbiology laboratories for the identification of Corynebacterium species and other coryneform bacteria. Detection of antibodies directed against DT is the only established serologic test for coryneform bacteria.

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Whole Genome Sequencing of First Janibacter indicus Isolate in China Revealed Three Unique Genomic Islands Compared with Saprophytic Strains

Cited by 3 publications

References 30 publications

Genome Sequencing Analysis of a Rare Case of Blood Infection Caused by Flavonifractor plautii

Genome Sequencing Analysis of a Rare Case of Blood Infection Caused by Flavonifractor plautii

Early-Life Skin Microbial Biomarkers for Eczema Phenotypes in Chinese Toddlers

Coryneform Gram‐Positive Rods

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