Whole genomic analyses of equine group A rotaviruses from Japan: Evidence for bovine-to-equine interspecies transmission and reassortment events

Ghosh, Souvik; Taniguchi, Koki; Aida, Satoru; Ganesh, Balasubramanian; Kobayashi, Nobumichi

doi:10.1016/j.vetmic.2013.07.016

Cited by 22 publications

(22 citation statements)

References 37 publications

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“…Equine RVAs have also been shown to present a high level of conservation in their genome constellations, with the VP7, VP6 and NSP4 gene segments being distinguished into two different genotypes, i.e. G3/G14, I2/I6 and E2/E12, respectively (Ghosh et al, 2013;Matthijnssens et al, 2012;Nemoto et al, 2015). Importantly, only one P type (P[12]) has been found in RVAs infecting horses, which indicates a high restriction at the species level.…”

Section: Discussionmentioning

confidence: 99%

“…All the equine RVA strains sequenced to date present the same genotype for the VP2 gene (C2) (Ghosh et al, 2013;Matthijnssens et al, 2012;Nemoto et al, 2015). As only two amino acid substitutions (I38V and V39I) were found in the VP6 : VP2 interacting region, which seem to compensate for each other (Ile for Val and vice versa), no major differences can be expected with the VP2 interaction, and therefore the same VP2 protein could be shared by the equine strains showing G3P [12] and G14P[12] genotypes.…”

Section: Discussionmentioning

confidence: 99%

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Genetic linkage of capsid protein-encoding RNA segments in group A equine rotaviruses

Miño¹,

Barrandeguy

Parreño³

et al. 2016

Journal of General Virology

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Rotavirus virions are formed by three concentric protein layers that enclose the 11 dsRNA genome segments and the viral proteins VP1 and VP3. Interactions amongst the capsid proteins (VP2, VP6, VP7 and VP4) have been described to play a major role in viral fitness, whilst restricting the reassortment of the genomic segments during co-infection with different rotavirus strains. In this work we describe and characterize the linkage between VP6 and VP7 proteins based on structural and genomic analyses of group A rotavirus strains circulating in Argentinean horses. Strains with the VP7 genotype G3 showed a strong association with the VP6 genotype I6, whilst strains with G14 were associated with the I2 genotype. Most of the differences on the VP6 and VP7 proteins were observed in interactive regions between the two proteins, suggesting that VP6 : VP7 interactions may drive the co-evolution and co-segregation of their respective gene segments.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Genetic linkage of capsid protein-encoding RNA segments in group A equine rotaviruses

Miño¹,

Barrandeguy

Parreño³

et al. 2016

Journal of General Virology

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“…Till 2013 only few reports for the whole genome characterization and analysis of equine RVA strains have been documented (Ghosh et al, 2012;Matthijnssens et al, 2012b;Mino et al, 2013). The strains characterized for their complete genomic constellations were three from Europe (Strain: L338; 03V04954 and 04V2024), three from Argentina (Strain: E30; E403 and E4040), one from South Africa (Strain: EqRV-SA1) and four from Japan (Stain: B1; HH-22; CH-3 and OH-4) (Ghosh et al, 2012;Matthijnssens et al, 2012b;Ghosh et al, 2013;Mino et al, 2013).…”

Section: Rotavirusesmentioning

confidence: 99%

“…The strains showing the possibility of interspecies transmission were equine G3P[18] RVA strain L338 (Matthijnssens et al, 2012b), H-1 strain believed to be transmitted from pigs to equines (Ghosh et al, 2012), whereas strain E3198 seemed to be resultant of canine/feline RVA strain to equines (Mino et al, 2013). Further, strengthening the need to analyze more common and uncommon equine RVA strains around the world the analysis done by two research groups were remarkable (Matthijnssens et al, 2012b;Ghosh et al, 2013). These reports established the fact that more or less out of the 11 segments of RVAs the interspecies transmission event are constantly changing the nature of equine RVA being detected in the horse population worldwide.…”

Section: Rotavirusesmentioning

confidence: 99%

Evolving views on enteric viral infections of equines: an appraisal of key pathogens

Sircar¹,

Saurabh²,

Kattoor³

et al. 2016

JEBAS

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Equines, the earliest known mammalian species, have been found highly susceptible to several enteric pathogens including viruses, fungi, parasites and bacteria. This review conserves with the key viral pathogens that affects foals and horses such as rotavirus, adenovirus, coronavirus, parvovirus, picobirnavirus etc. With the advent of next generation sequencing approaches the list of new enteric viruses has expanded. Viruses like Cyclovirus, Kirkovirus and Anellovirus are the new members identified in equines recently. Close proximity of horses to human settlements and/or other domestic animals pretense the threat of infectious diseases spread to humans/animals and vice-versa. Therefore, horse diseases are not only of veterinary importance but also are among important factors for public health. Herein, we intend to appraise current status of key enteric viruses that cause diarrheic disorders in foals and horses.

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“…The VP7 and VP4 genes, encoding outer capsid, are used to classify rotaviruses into G and P genotypes, respectively (Kapikian, 2001). Group A equine rotavirus (ERV) is the major cause of diarrhea in foals up to 3 months of age and the acute dehydration can incur severe economic burden due to morbidity and mortality in studs (Bailey et al, 2013; Ghosh et al, 2013; Papp et al, 2013). The G3P[12] and G14P[12] are the most prevalent equine rotavirus strains worldwide (Ghosh et al, 2013; Papp et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Cloning and nucleotide sequence analyses of 11 genome segments of two American and one British equine rotavirus strains

Wen

Hoshino

et al. 2015

Veterinary Microbiology

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Group A equine rotavirus (ERV) is the main cause of diarrhea in foals and causes severe economic loss due to morbidity and mortality on stud farming worldwide. Molecular evolution of equine rotaviruses remains understudies. In this study, whole-genomic analysis of 2 group A ERV, FI-14 (G3P[12]), H-2 (G3P[12]) isolated from American, and FI23 (G14P[12]) from British was carried out and genotype constellations were determined as G3-P[12]-I6-R2-C2-M3-A10-N2-T3-E2-H7 for FI-14; G14-P[12]-I2-R2-C2-M3-A10-N2-T3-E2-H7 for FI23; and G3-P[12]-I6-R2-C2-M3-A10-N2-T3-E2-H7 for H-2, respectively. With the exception of the VP7 and VP6 gene, 2 G3P[12] strains (FI-14 and H-2) and one G14P[12] strain (FI23) were highly related genetically. Of note, the VP6 genotype of H-2 strain was previously reported to be I2, however, sequence and phylogenetic analyses demonstrated that it was I6. Therefore, it showed that G3P[12] ERV strains and G14P[12] ERV strains bore a distinct VP6 genotype: I6 for G3P[12] strains and I2 for G14P[12] strains. Moreover, it demonstrated that T-cell epitope 299P-300P/Q residues (PP/Q) of VP6 may be considered as I2 ERV typical molecular marker, which facilitates the analysis of the molecular evolution of equine rotaviruses.

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Whole genomic analyses of equine group A rotaviruses from Japan: Evidence for bovine-to-equine interspecies transmission and reassortment events

Cited by 22 publications

References 37 publications

Genetic linkage of capsid protein-encoding RNA segments in group A equine rotaviruses

Genetic linkage of capsid protein-encoding RNA segments in group A equine rotaviruses

Evolving views on enteric viral infections of equines: an appraisal of key pathogens

Cloning and nucleotide sequence analyses of 11 genome segments of two American and one British equine rotavirus strains

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