Whole grain benefit: synergistic effect of oat phenolic compounds and β-glucan on hyperlipidemia<i>via</i>gut microbiota in high-fat-diet mice

Li, Ying; Qin, Chuan; Dong, Lezhen; Zhang, Xin; Wu, Zufang; Liu, Lingyi; Yang, Junsi; Liu, Lianliang

doi:10.1039/d2fo01746f

Cited by 79 publications

(59 citation statements)

References 44 publications

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“…Despite their similarities in macronutrient composition, these dietary patterns had distinctly different outcomes. As such, although macronutrient profile may partially explain diet-disease relationships, other aspects of a dietary pattern, including source of macronutrients (e.g., plant vs. animal), levels of food processing, food structure, micronutrients, phytochemicals, antioxidants, such as phenolic compounds [ 68 ], fatty acid profile, fibre content, etc., likely have contributed to the observed effects of dietary patterns and act as a combined matrix to affect health and NCD outcomes. Although accounting for these dietary aspects is beyond the scope of our work, it would be an area of importance for future research.…”

Section: Discussionmentioning

confidence: 99%

Dietary Patterns and Non-Communicable Disease Biomarkers: A Network Meta-Analysis and Nutritional Geometry Approach

Liang

Mijatovic

et al. 2022

Nutrients

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Quantitative rankings of multiple dietary patterns for their effects on non-communicable disease (NCD) biomarkers is lacking and would inform primary prevention strategies. Accordingly, a network meta-analysis (NMA) was conducted to compare and rank the effects of different dietary patterns on NCD biomarkers, and associations of dietary patterns’ underlying macronutrient composition with NCD biomarkers were determined by a nutritional geometry approach. Randomised controlled trials (RCTs) were eligible for inclusion if they enrolled healthy participants, employed food-based dietary pattern interventions without energy restriction, and reported NCD biomarker outcomes. NCD biomarkers were included as an outcome if ≥10 trials were available. A systematic search of five electronic databases identified 4008 records. Sixty-eight articles from 59 RCTs reporting lipids, glycemic, and inflammatory biomarkers were included for quantitative syntheses. Risk-of-bias was predominantly categorized as low or having some concerns, and confidence-of-evidence low. Relative to western habitual diet, the Mediterranean, Dietary Approaches to Stop Hypertension (DASH), dietary guidelines-based, plant-based, and low-fat diets reduced low-density lipoprotein cholesterol (mean difference range: −0.29 to −0.17 mmol/L), total cholesterol (−0.36 to −0.24 mmol/L), and apolipoprotein B (−0.11 to −0.07 g/L) (all p < 0.05); the Paleo, plant-based and dietary guidelines-based diets reduced homeostasis model assessment of insulin resistance (−0.95 to −0.35, all p < 0.05). No dietary pattern ranked consistently highest. The Paleo diet received the highest all-outcomes-combined average Surface Under the Cumulative Ranking Curve value (67%), followed by DASH (62%) and Mediterranean diets (57%), whereas western habitual diet was lowest (36%). Our findings were independent of macronutrient composition, highlighting the significance of dietary pattern-level analysis.

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Section: Discussionmentioning

confidence: 99%

Dietary Patterns and Non-Communicable Disease Biomarkers: A Network Meta-Analysis and Nutritional Geometry Approach

Liang

Mijatovic

et al. 2022

Nutrients

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“…191 Li et al, mentioned in their study that β-glucans are effective in regulating hyperlipidemia. 195 They also inhibit tumor growth and strengthen the immune system, as well as regulate resistance to colon-specific diseases like ulcerative colitis and Crohn's disease. 191 Further, the delivery of several bioactive compounds has been essential for neuro-regeneration, 93 wound healing, 91 diabetes treatment, 108 cancer therapy, 152 and bone healing, 66 etc.…”

Section: Biosensormentioning

confidence: 99%

“…Interestingly, polysaccharides are known to exhibit health benefits so Eyigor et al utilized β-glucan for thermoresponsive delivery of mesalazine or 5-aminosalicylic acid (5-ASA) which is an anti-inflammatory drug . Li et al, mentioned in their study that β-glucans are effective in regulating hyperlipidemia . They also inhibit tumor growth and strengthen the immune system, as well as regulate resistance to colon-specific diseases like ulcerative colitis and Crohn’s disease .…”

Section: Emerging Applicationsmentioning

confidence: 99%

Stimuli-Responsive Polysaccharide-Based Smart Hydrogels and Their Emerging Applications

Srivastava

Choudhury

2022

Ind. Eng. Chem. Res.

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Hydrogels are a soft material that undergoes cross-linking between polymers to form a hydrophilic three-dimensional network. In fact, similarity to body tissue, soft consistency, biocompatibility, and elasticity, impart a protagonic role of hydrogel to be applied as a biomaterial. In response to external cues, stimuli-responsive hydrogels are particularly impactful, enabling remarkable levels of control over material properties. They can endure changes in swelling behavior, permeability, network structure, and mechanical strength. Nevertheless, such changes induce single-cycle or reversible transitions, so hydrogels can regain their initial state once the trigger is removed. Recently, polysaccharide-based hydrogels with stimuli-responsive properties resulted in developing biomimetic structures for a widespread biotechnological application owing to their excellent biodegradability, biocompatibility, nonimmunogenicity, functional properties, ease of gelation, and derivatization. This review will initially highlight recent advances in cross-linking methods and chemistry for preparing stimuli-responsive hydrogels. Subsequently, state-of-the-art techniques to understand the structural, chemical, and rheological behavior of polysaccharide-based stimuli-responsive hydrogel will be discussed. Additionally, the responsiveness of polysaccharide hydrogel toward diverse stimuli such as redox, temperature, light, pH, magnetism, electricity, etc., with a broad spectrum of applications will be described in detail. This review also attempts to address the lacunae of existing stimuli-responsive hydrogel and their future perspectives.

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“…The management of dyslipidaemia is another example of once the biology of the disease has been addressed then healthy behaviours may play an invaluable role in optimising self-care within a chronic disease management strategy. For example, there now appears synergism of how whole grain can benefit the management of dyslipidaemia via gut microbiota [ 30 ].…”

Section: Once Obesity Is Effectively Treated Patients Lose Weight Wit...mentioning

confidence: 99%

The Concept of Healthy Behaviours in Obesity May Have Unintended Consequences

Craig

Doran²,

Roux

2022

Nutrients

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Obesity has become a global epidemic, representing a major health crisis, with a significant impact both in human and financial terms. Obesity was originally seen as a condition, not a disease, which was considered self-inflicted. Thus, it was understandable that a simplistic approach, such as eat less and move more was proposed to manage obesity. Over the last 25 years, the perception of obesity has been gradually changing and the awareness has risen that it is a disease in its own right and not just a precipitating factor for type 2 diabetes, non-alcoholic fatty liver disease (NAFLD), etc. Creation of a comprehensive algorithm for the management of obesity needs to be informed by an in-depth understanding of the issues impacting the provision of treatment. Promotion of healthy behaviours is essential to help the population become healthier, but these are not obesity treatment strategies. Twenty percent of patients with obesity may respond to approaches based on healthy behaviour, but the 80% who do not respond should not be stigmatised but rather their treatment should be escalated. The unintended consequences of promoting healthy behaviours to patients with obesity can be mitigated by understanding that obesity is likely to be a subset of complex diseases, that require chronic disease management. Once the biology of the disease has been addressed, then healthy behaviours may play an invaluable role in optimising self-care within a chronic disease management strategy.

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Whole grain benefit: synergistic effect of oat phenolic compounds and β-glucan on hyperlipidemiaviagut microbiota in high-fat-diet mice

Abstract: Increasing evidence has confirmed that whole grain oats are effective in regulating hyperlipidemia. Which specific ingredient is crucial remains unclear. This study focused on which components, oat phenolic compounds (OPC)...

Cited by 79 publications

References 44 publications

Dietary Patterns and Non-Communicable Disease Biomarkers: A Network Meta-Analysis and Nutritional Geometry Approach

Dietary Patterns and Non-Communicable Disease Biomarkers: A Network Meta-Analysis and Nutritional Geometry Approach

Stimuli-Responsive Polysaccharide-Based Smart Hydrogels and Their Emerging Applications

The Concept of Healthy Behaviours in Obesity May Have Unintended Consequences

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