Whole Heart Cytoarchitecture at Micron-Scale Resolution

Abstract

The accelerated utilization of human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CM) for drug screening and disease modeling requires adaptation of high-throughput technology for more efficient evaluation. Multiple technologies have emerged including single/multi-electrode array for extracellular field potential (EFP) detection, and voltage sensitive dyes and automated patch-clamp for action potential measurement. EFP assessment to date predominantly is performed on spontaneously beating hiPSC-CM, howev