Whole transcriptome analysis of long noncoding RNA in beryllium sulfate-treated 16HBE cells

Chen, Shaoxiong; Sun, Zhanbing; Deng, Weihua; Li, Guilan; Liu, Xiuli; Zhang, Zhaohui

doi:10.1016/j.taap.2022.116097

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2023

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“…A field of great interest is the search for molecules that can behave as chelating agents of Be 2+ with the purpose to find detoxifying compounds; these compounds are generally carboxylic acids or carboxylate anions [19,33,34]. Finally we must remember the problem encountered when using X-ray crystallography: due to the low number of electrons in Be 2+ (only two), its localization is not possible via protein X-ray crystallography [21,35]. This problem is the same with hydrogen atoms (only one electron).…”

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confidence: 99%

The dubious origin of beryllium toxicity

Elguero

Alkorta

2023

Struct Chem

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Four mechanisms have been proposed in the literature to explain beryllium toxicity; they can be divided in two groups of two mechanisms: (i) replacement type: models 1 and 2; (ii) addition type: models 3 and 4. At this moment is not possible to select the best model not even to establish if one of these models will be the ultimate mechanism of beryllium toxicity. However, it is important to know the still open discussion about something so important associated with one of the simplest elements of the periodic table.

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