Researchers have studied the effects of common, subtle forms of discrimination called microaggressions among various marginalized groups. We conducted three experimental studies (Ns = 45, 61, and 90) on microaggressions toward transgender individuals, connecting the microaggression and social exclusion literatures. Specifically, we hypothesized that microaggressions would have similar negative psychological effects as other forms of social exclusion (e.g., interpersonal rejection and ostracism). In Studies 1 and 2, we used an adapted recall paradigm in which participants recalled and wrote about either a control or a microaggression autobiographical event. In Study 3, we added an explicit social exclusion condition. Participants then reported how they felt during the event on measures of perceived pain, feelings of being excluded/ignored, perceived relational value, and basic need satisfaction. All three studies provide converging evidence that participants recall experiencing microaggressions similarly to how individuals typically experience social exclusion, suggesting theoretical and empirical benefits to connecting these two areas and offering avenues for future research.