In the testicles, the expression of Angiotensin-Converting Enzyme 2 receptors makes it more susceptible to infection by Sars-CoV-2 and, therefore, to male infertility with significant health problems for the patient. Therefore, this study aimed to analyze the clinical pathophysiology and the mechanisms involved in the genesis of male infertility from COVID-19, through the critical analysis of the main scientific evidence on the subject presented so far. From an integrative review of the literature containing 30 studies selected using inclusion criteria in the period 2020-2021, the direct and indirect impacts on male fertility in pathophysiological and psychosocial terms were observed in this study, in addition to therapeutic options, guidelines host and efficient semiological approach. Thus, the impact of the pandemic, even after one year, is immeasurable. Additional studies to reveal the real consequences and the mechanism by which the disease can affect male fertility are still needed. It is essential to pay more attention to male genital exams in patients with COVID-19. The psychobiological consequences of the pandemic in infertile patients should not be underestimated.