Why dexamethasone can reduce mortality rate among patients with viral infections

Abstract

As an anti-inflammatory hormone, dexamethasone may minimize proton buildup and down-regulate the production of oxalate. The reduced generation of insoluble and stiff calcium oxalate might account for the substantial drop of mortality rates by dexamethasone amid the current COVID-19 pandemic.

The integration of lysine supplement and weak organic acids may hold the key to a longer lifespan

“…Lysine supplement was previously reported to be beneficial for heart disease patients (Linus Pauling, 1991;1993). The underlying mechanism may be that positively charged lysine residues in basic proteins can build up Clwhich solubilizes insoluble and stiff calcium oxalate and other insoluble salts (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11), in a way similar to salting the road to disrupt hydrogen bonding of ice by strong anion Cl -. Lysine supplement may modify the proteome and augment the expression of lysine-rich proteins (1,12).…”

“…Calcium oxalate is a primary component of renal stones which can advance to renal failure and reduce life expectancy (13). Similar in structure to oxalate, alcohol and acetic acid are favorable to heart disease patients and extends lifespan, likely via the inhibition of generation and function of oxalate (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). Therefore, lysine supplement can prolong lives to individuals with constipation, heart disease, Alzheimer's disease, SARS, SARS-CoV-2, renal stones, etc., since patients with these disorders have insoluble salts in their bodies (1).…”