BACKGROUND AND OBJECTIVE: Advanced understanding of modifiable predictors of health care use in pediatric chronic illness is critical to reducing health care costs. We examined the relationship between medication non-adherence and health care use in children and adolescents who have a chronic medical condition.
METHODS:A systematic review of articles by using PubMed, PsycINFO, and CINAHL was conducted. Additional studies were identified by searching reference sections of relevant manuscripts. Studies that tested the relationship between medication non-adherence and health care use (ie, hospitalizations, emergency department visits, outpatient visits) or cost in children and adolescents (mean age #18 years) who have a chronic medical condition were included. Extraction of articles was completed by using predefined data fields.
RESULTS:Ten studies met our inclusion criteria. Nine of the 10 studies reviewed (90%) demonstrated a relationship between medication nonadherence and increased health care use. The directionality of this relationship varied depending on the outcome variable of interest.
FUNDING:The design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation of the manuscript were supported in part by grant T32HD068223 for Dr McGrady. Dr Hommel is funded in part by R01HD067174. Funded by the National Institutes of Health (NIH).
POTENTIAL CONFLICT OF INTEREST:The authors have indicated they have no potential conflicts of interest to disclose.
730McGRADY and HOMMEL by guest on May 11, 2018 http://pediatrics.aappublications.org/ Downloaded from In 2010, the United States spent $2.6 trillion on health care, an increase of 3.9% from 2009, and 17.9% of its gross domestic product. 1 Hospital care and physician and clinical services (ie, emergency department [ED] visits, hospitalizations, and office visits, hereafter defined as "health care use") are the 2 largest components of health care spending, 2,3 and accounted for over 50% of the growth in health care spending from 2009 to 2010. 1 Continued rising health care costs despite the recession, the increasing US national deficit, and the increasing percentage of US health spending financed by the government ($1.2 trillion, 45% of all US health spending) have prompted investigation of modifiable factors to reduce health care use and associated costs. 4 Although there is no single strategy for effectively controlling costs, researchers have begun to focus on the 83% of health care resources consumed by individuals who have a chronic medical condition. 4,5 The number of children and adolescents diagnosed with a chronic medical condition has been steadily increasing over the past 20 years, 6 driven in part by increases in the prevalence of obesity 7 and asthma 8 as well as advances in medical care that increase survival (eg, cystic fibrosis, kidney transplant). 9,10 Increases in the prevalence of chronic medical conditions have only increased the already disproportionate health care expenses accounted for...