2011
DOI: 10.1002/bies.201100017
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Why is it crucial to reintegrate pathology into cancer research?

Abstract: The integration of pathology with molecular biology is vital if we are to enhance the translational value of cancer research. Pathology represents a bridge between medicine and basic biology, it remains the gold standard for cancer diagnosis, and it plays an important role in discovery studies. In the past, pathology and cancer research were closely associated; however, the molecular biology revolution has shifted the focus of investigators toward the molecular alterations of tumors. The reductionist approach … Show more

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Cited by 16 publications
(24 citation statements)
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“…Furthermore, the insights gleaned from studying normal cellular lineages must be related to disease states [ 3 , 4 ]. This integration process has not been always successful, partly due to lack of communication between different fields of research, decreasing number and lack of involvement of CTB experts [ 1 , 5 8 ]. Here, we examine some of the factors that contribute to these challenges.…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, the insights gleaned from studying normal cellular lineages must be related to disease states [ 3 , 4 ]. This integration process has not been always successful, partly due to lack of communication between different fields of research, decreasing number and lack of involvement of CTB experts [ 1 , 5 8 ]. Here, we examine some of the factors that contribute to these challenges.…”
Section: Introductionmentioning
confidence: 99%
“…Surgical pathology has become the ‘gold standard’ for the diagnosis of tumors [1]. When morphological features of the tumor are not adequate for a definitive diagnosis, immunohistochemistry (IHC) may be of benefit [2].…”
Section: Introductionmentioning
confidence: 99%
“…The involvement of pathologists is essential in preclinical, as well as in clinical cancer research [ 5 , 12 ]. In Saudi Arabia, most of the clinical cancer research was led by pathologists [ 8 ].…”
Section: Discussionmentioning
confidence: 99%