Wickerhamomyces anomalus blood stream infection in a term newborn with pneumonia

Yılmaz-Semerci, Seda; Demırel, Gamze; Tastekin, Ayhan

doi:10.24953/turkjped.2017.03.021

Cited by 19 publications

(9 citation statements)

References 20 publications

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“…LEfSe result showed that the relative abundance of Wickerhamomyces anomalus and Meyerozyma caribbica were significantly higher in the diarrheal group. It has been reported that Wickerhamomyces anomalus is a zoonotic pathogen that can cause severe iatrogenic infections and multiple clinical symptoms in animals (76,77). Meyerozyma caribbica is a gut fungus associated with diarrhea (65).…”

Section: Discussionmentioning

confidence: 99%

Gut Microbial Alterations in Diarrheal Baer's Pochards (Aythya baeri)

Qin

Song

et al. 2021

Front. Vet. Sci.

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The structure and composition of gut microbiota correlate with the occurrence and development of host health and disease. Diarrhea can cause alterations in gut microbiota in animals, and the changes in the gut microbial structure and composition may affect the development of diarrhea. However, there is a scarcity of information on the effects of diarrhea on gut fungal composition and structure, particularly in Baer's pochard (Aythya baeri). The current study was performed for high-throughput sequencing of the fungal-specific internal transcribed spacer 1 (ITS-1) to detect the differences of gut mycobiota in healthy and diarrheal Baer's pochard. Results showed that the gut mycobiota not only decreased significantly in diversity but also in structure and composition. Statistical analysis between two groups revealed a significant decrease in the abundance of phylum Rozellomycota, Zoopagomycota, Mortierellomycota, and Kickxellomycota in diarrheal Baer's pochard. At the genus levels, fungal relative abundance changed significantly in 95 genera, with 56 fungal genera, such as Wickerhamomyces, Alternaria, Penicillium, Cystofilobasidium, and Filobasidium, increasing significantly in the gut of the diarrheal Baer's pochard. In conclusion, the current study revealed the discrepancy in the gut fungal diversity and community composition between the healthy and diarrheal Baer's pochard, laying the basis for elucidating the relationship between diarrhea and the gut mycobiota in Baer's pochard.

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Section: Discussionmentioning

confidence: 99%

Gut Microbial Alterations in Diarrheal Baer's Pochards (Aythya baeri)

Qin

Song

et al. 2021

Front. Vet. Sci.

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“…Oscillospira, the other major hub in HC network, is a probiotic organism that showed negative interaction with pathogens like Slackia, Penicillium, Gemella, and Fusobacterium. 49 Another major hub was Prevotella, which interacted negatively with microbes that functionally could be characterized as pathogens (Treponema, Rothia, Clostridium, Atopobium), anti-inflammatory (Bifidobacterium, Clostridium, Bacteroides, Butyricimonas, Anaerostipes), and probiotic (Bifidobacterium, Veillonella, and Bacteroides). It would appear that the majority of the interactions were directed toward controlling the dominance of pathogenic microbes in the HC gut microbiome and this is anticipated.…”

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confidence: 99%

Implicating Dysbiosis of the Gut Fungal Microbiome in Uveitis, an Inflammatory Disease of the Eye

Jayasudha

Chakravarthy

Prashanthi

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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In this study, the gut fungal microbiome of uveitis (UVT) patients was generated and compared with healthy controls (HC) to identify dysbiosis in UVT patients and ascertain the role of gut fungal microbiome in disease pathology. METHODS. In the present study, gut fungal microbiomes were analyzed in the fecal samples of HC (n ¼ 24) and UVT patients (n ¼ 14) using high-throughput Illumina sequencing of ITS2 region of the fungal ribosomal RNA. QIIME and R software were used for data analysis. RESULTS. The gut fungal richness and diversity were significantly decreased in UVT patients compared to HC. Our analyses showed enrichment of several pathogenic fungi including Malassezia restricta, Candida albicans, Candida glabrata, and Aspergillus gracilis in UVT patients. Heatmap and discriminatory OTUs further confirmed the disparities between UVT and HC microbiomes. CONCLUSIONS. This is the first study demonstrating dysbiosis in the gut fungal communities of UVT patients indicating the importance of fungal microbiome in the disease pathology. These initial findings might warrant further investigation into the fungal microbiome, especially interactions between fungal and bacterial that then might give further insight into how probiotics or fecal transplants might benefit.

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“…Additionally, fungi possess a number of facilitating attributes such as dimorphism, adhesins and invasins, proteases and biofilm-forming capabilities [ 22 ], which can further enhance pathogenesis and lead to infectious species crossing over from the dermis to the systemic circulation causing invasive mycoses. Opportunistic yeasts such as M. pachydermatis , W. anomalus and B. pseudobassiana are becoming of increasing importance in both animal and human diseases, where these pathogens are now being reported in cases of fungemia, where neonates and ICU patients are at most risk [ 5 , 23 , 24 , 25 , 26 , 27 ]. Such findings emphasise the importance of considering these pathogens within the diagnostics realm, where current CBPs are lacking.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Alternative Therapeutic and Biocidal Options to Combat Antifungal-Resistant Zoonotic Fungal Pathogens Isolated from Companion Animals

Meade

Savage²,

Slattery³

et al. 2021

Infectious Disease Reports

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Fungal skin infections and iatrogenic disease of companion animals continue to be an ongoing issue for veterinarians, where misdiagnosis or inapt medical treatment result in secondary conditions within animals. The widespread use of antifungals in both modern medicine and agriculture has resulted in concomitant resistance in species, where zoonotic transfer poses a risk to public health. Studies described herein assess the resistance of pathogenic species isolated from companion animals to a battery of conventional antimicrobial agents. Levels of resistance were detected using recognised in vitro methods, where additional novel therapeutic and biocide options were also extensively investigated. Results show high levels of resistance to the three main families of antifungal agents, namely caspofungin, Amp B and fluconazole. Resistance in Candida, Cryptococcal, Aspergillus and Trichophyton species is described herein, highlighting the need for defined species-specific antifungal breakpoints, and for Malassezia and Wickerhamomyces anomalus species which also have zoonotic potential. Novel compound phendione showed promising antimicrobial activity, with MICs determined for both fungal and bacterial species. The biocidal options investigated also showed potential to act as intermediate-level disinfectants, where peracetic acid proved most effective against fungal spore formers.

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Wickerhamomyces anomalus blood stream infection in a term newborn with pneumonia

Cited by 19 publications

References 20 publications

Gut Microbial Alterations in Diarrheal Baer's Pochards (Aythya baeri)

Gut Microbial Alterations in Diarrheal Baer's Pochards (Aythya baeri)

Implicating Dysbiosis of the Gut Fungal Microbiome in Uveitis, an Inflammatory Disease of the Eye

Investigation of Alternative Therapeutic and Biocidal Options to Combat Antifungal-Resistant Zoonotic Fungal Pathogens Isolated from Companion Animals

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