With the popularity of 5 G, there is an increasing request for a light, high-performance, and stable structure for wireless communication. To solve the problems of delamination cracking and its own heavy weight of the conventional microstrip antenna, this study used ultra-high molecular weight polyethylene (UHMWPE) filament tows and purple copper filament tows as raw materials to prepare 3D woven hollow structure microstrip antenna preforms on a common loom. Using the prepared preforms for reinforcement and resin as the matrix, the VARTM process was used to prepare a 3D woven hollow structure microstrip antenna with a height of 6.8 mm, a weight of 35 g, and a bulk density of 0.7 g/cm3. The combination of the electromagnetic performance test and HFSS software simulation shows that the antenna has excellent radiation performance with a gain of 7.5 dB and a measured VSWR of 1.25. The mechanical performance test results show that it can withstand a maximum compression load of 2982 N and a maximum bending load of 364 N with no obvious delamination at the fracture. It is light, thin, and load-bearing with excellent radiation performance. There will be great potential in the unmanned field and the space field in the future.