Wide resection and reconstruction in a low resource area, cemented nail technique knee arthrodesis; a report of case and surgical technique

Elbahari, Hassan Mohammed Hassan; Abd-Elmaged, Hozifa Mohammed Ali; Abdulkarim, Mohamed; Ahmed, Mohammed Mubarak Mohammed; Medani, Mohamed Medani Elhag

doi:10.1016/j.ijscr.2022.107621

Cited by 3 publications

(2 citation statements)

References 21 publications

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“… 1 It accounts for around 20% of all primary bone tumours. 2 Most such tumours have metastasised by the time they are diagnosed, mainly to the lungs. 3 Surgical resection of the primary lesion serves as the main treatment for osteosarcoma, but postoperative recurrence and metastasis are common, resulting in poor prognoses for patients, with low survival rates averaging only five years.…”

Section: Introductionmentioning

confidence: 99%

Effects of combined sintilimab and chemotherapy on progression-free survival and overall survival in osteosarcoma patients with metastasis

Li,

Zhang,

et al. 2024

Pak J Med Sci

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Objective: To explore the safety and efficacy of metastatic osteosarcoma treatment with combined sintilimab injection and chemotherapy. Methods: We performed a retrospective analysis of 32 patients with metastatic osteosarcoma admitted to the Affiliated Hospital of Beihua University between January 2019 and June 2020. The sample was divided into an observation group, treated with sintilimab injection combined with chemotherapy (n= 16) and a control group, treated with chemotherapy (n = 16). Clinical efficacy and adverse reactions were compared between the two groups. Results: The overall response rates were 68.75% in the observation group and 31.25% in the control group (p < 0.05). The incidences of adverse reactions were 56.25% in the observation group and 81.25% in the control group. This was not a significant difference. In the observation group, the progression-free survival time was 8.13 ± 2.50 months, and the overall survival time was 22.75 ± 4.95 months. These were both significantly longer than the respective 6.44 ± 1.93 months and 19.69 ± 2.68 months in the control group (p < 0.05). Conclusion: The treatment of metastatic osteosarcoma with combined sintilimab injection and chemotherapy was found to prolong progression-free survival and overall survival time without increasing the incidence of adverse reactions. doi: https://doi.org/10.12669/pjms.40.4.8536 How to cite this: Li F, Zhang D, Ma Y, Song Y, Duan X. Effects of combined sintilimab and chemotherapy on progression-free survival and overall survival in osteosarcoma patients with metastasis. Pak J Med Sci. 2024;40(4):648-651. doi: https://doi.org/ 10.12669/pjms.40.4.8536 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Introductionmentioning

confidence: 99%

Effects of combined sintilimab and chemotherapy on progression-free survival and overall survival in osteosarcoma patients with metastasis

Li,

Zhang,

et al. 2024

Pak J Med Sci

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“…Recently, some scholars have achieved certain success by using bone cement combined with internal xation as an ultimate treatment for addressing the limitations of knee joint fusion in patients with knee joint bone infection [19][20][21][22]. Since 2014, our team has utilized antibiotic-loaded bone cement combined with tibial intramedullary nail as the ultimate treatment approach for 11 elderly patients with knee joint bone infection.…”

Section: Introductionmentioning

confidence: 99%

The use of antibiotic-loaded bone cement combined with tibial intramedullary nail as last resort treatment in 11 elderly patients with knee joint bone infection

Li,

Zhang,

et al. 2024

Preprint

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Background The management of bone infections has always posed a challenge in the field of orthopedics, and geriatric knee joint bone infections are even more difficult. In this study, we aimed to assess the clinical efficacy of using antibiotic-loaded bone cementcombined with tibial intramedullary nail as a last resort treatment option for geriatric knee joint bone infection patients. Methods The retrospective study was conducted on 11 elderly patients with knee joint bone infection. The cohort comprised 3 male and 8 female patients, with an average age of 74.27±3.47years. Of these patients, 4 patients experienced reinfection after knee revision replacement, while 7 patients had knee joint bone infection.After stage-1 infection control, all patients underwent a stage-2 treatment using antibiotic-loaded bone cement combined with tibial intramedullary nail as the ultimate treatment approach. Results All patients’ infections were effectively controlled. The average length of bone defect after debridement was 12.09±1.22cm. The duration of the stage-2 operation averaged180.27±11.06minutes. Postoperatively, there was no significant discrepancy in the length of the patients’ lower limbs. All patients experienced a significant enhancement in knee joint function, as indicated by the decrease in WOMAC scores from 141.45±11.75preoperatively to 79.09±0.34postoperatively. Pain levels saw a profound reduction, plummeting from 26.27 ± 2.45 to a non-existent 0.00 ± 0.00. Additionally, there was a substantial improvement in performing daily activities, rising impressively from 59.09 ± 0.34 to 100.55 ± 8.37. However, an increase in joint stiffness was noted, worsening slightly from 15.45 ± 1.63 to 20.00 ± 0.00.One case of peri-implant fracture occurred. Conclusion Antibiotic-loaded bone cement combined with tibial intramedullary nailing as last resort treatment can be considered as an alternative surgical option for elderly patients with knee joint bone infection who have experienced multiple failed operations and long-term knee stiffness.

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Advancements in Understanding the Role of Circular RNA in Osteosarcoma

Wang,

Zhang,

2023

Mol Biotechnol

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Wide resection and reconstruction in a low resource area, cemented nail technique knee arthrodesis; a report of case and surgical technique

Cited by 3 publications

References 21 publications

Effects of combined sintilimab and chemotherapy on progression-free survival and overall survival in osteosarcoma patients with metastasis

Effects of combined sintilimab and chemotherapy on progression-free survival and overall survival in osteosarcoma patients with metastasis

The use of antibiotic-loaded bone cement combined with tibial intramedullary nail as last resort treatment in 11 elderly patients with knee joint bone infection

Advancements in Understanding the Role of Circular RNA in Osteosarcoma

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