Widespread Bullous Fixed Drug Eruption Mimicking Toxic Epidermal Necrolysis

Baird, Bonnie J.; Villez, Richard L. De

doi:10.1111/j.1365-4362.1988.tb04923.x

Cited by 50 publications

(34 citation statements)

References 19 publications

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“…[9][10][11] Olgunun genel durumunun iyi olması, daha önce de ilaç kullanımı sonrası daha lokalize lezyon hikâyesinin olması, mukozal tutulumun nadir olması, küçük bir vücut yüzey alanının tutulması, kahverengimsi mor renkli yama lezyonların üzerinde yumuşak büllerin görülmesi GBFİE'yi destekleyen klinik bulgulardır.…”

Section: Discussionunclassified

“…Literatürde diğer bildirilen hastalarda da klinik ya da klinik ve histopatolojik olarak tanı konulmuştur. 6,[9][10][11][12][13][14][15][16][17][18] Özellikle antibiyotikler, analjezikler, antipsikotikler ve hipnotik ilaçlara bağlı olarak gelişir. 1 Türkiye'de en sık bildirilen sorumlu ajan ise trimetoprim-sülfametoksazol ile naproksen sodyumdur.…”

Section: 8unclassified

“…18 Diğer bildirilen büllöz fiks ilaç erüpsiyonlarında interdijital tutulum saptanmamıştır. [9][10][11][12][13][14][15][16][17] Fiks ilaç erüpsiyonunun neden belli bir bölgeyi tuttuğu hâlâ gizemini korumaktadır. İlaç, travma veya visserokutanöz refleksle ilişkili olup olmadığı ile ilgili çalışmalar yapılmaktadır.…”

Section: 8unclassified

See 2 more Smart Citations

Generalized Bullous Fixed Drug Eruption: Case Report

Duman¹,

Topal²,

Cüre³

et al. 2016

Turkiye Klinikleri J Dermatol

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Section: Discussionunclassified

Section: 8unclassified

See 1 more Smart Citation

Generalized Bullous Fixed Drug Eruption: Case Report

Duman¹,

Topal²,

Cüre³

et al. 2016

Turkiye Klinikleri J Dermatol

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“…While SJS-TEN lesions affect the dermoepidermal junction with lymphocytic infiltrate, FDEs are identified by vacuolar interface dermatitis with epidermal necrosis and a superficial and deep perivascular infiltrate of lymphocytes, eosinophils and neutrophils 2. Despite these differentiating features, precise delineation remains a challenge and often relies on the acumen and experience of the clinician and dermatopathologist 3 4…”

Section: Discussionmentioning

confidence: 99%

Widespread bullous fixed drug eruption

et al. 2014

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SUMMARYA 53-year-old man developed a widespread erythematous eruption which rapidly evolved into fluidfilled bulla mostly involving the distal areas of all four limbs and erosions on the oral as well as anogenital mucosa. Based on clinical presentation, chronology of drug exposure, past events and histopathology as diagnosis of widespread bullous fixed drug eruption was made over Steven Johnson-toxic epidermal necrolysis syndrome. Steroids were deferred and the lesions healed with minimal pigmentation within a week. Differentiating between the two entities has been historically difficult, and yet can have significant therapeutic and prognostic implications. BACKGROUND

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“…7 Again, localized hyperpigmentation is a common complication, but pain, infection, and, rarely, hypopigmentation, also may occur.…”

Section: Introductionmentioning

confidence: 99%

A fixed dose combination of ofloxacin and ornidazole induced fixed drug eruptions

Manchukonda

Thippeswamy

2018

Int J Basic Clin Pharmacol

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Fixed drug eruptions (FDEs) may account for 16-21% of all cutaneous drug eruptions. Recent research suggests a cell-mediated process that initiates both the active and quiescent lesions. The major categories of causative agents of fixed drug eruption include antibiotics, antiepileptics, nonsteroidal anti-inflammatory agents, sildenafil, and phenothiazines, although numerous other agents and certain foods such as cashews and licorice have also been reported as causative agents. A 38 year old male presented to the dermatology OPD with hyperpigmented and erythematous macular eruptions on the neck, chest, right arm, left scapular region, left wrist and left knee. The eruptions were associated with burning sensation and itching. He informed having taken medications for gastroenteritis the night before. The medications were Ofloxacin and Ornidazole (FDC), Omeprazole and Domperidone (FDC) and Paracetamol. He gave a history of a similar event, a year ago, with the same antimicrobial combination (Ofloxacin and Ornidazole), although the macular eruptions were restricted to the neck, arm and knee with bleb formation and severe burning sensation. Since the macular eruptions reoccurred, although with extra regions being affected, a diagnosis of FDEs was made. The most probable cause for these FDEs seems to be FDC of Ofloxacin and Ornidazole, because the patient gives history of taking Omeprazole and Paracetamol before without any FDEs. According to Naranjo’s Adverse Drug Reaction Probability Scale, the FDC of Ofloxacin and Ornidazole is a definite cause for the FDEs. (Score = 9).

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Widespread Bullous Fixed Drug Eruption Mimicking Toxic Epidermal Necrolysis

Cited by 50 publications

References 19 publications

Generalized Bullous Fixed Drug Eruption: Case Report

Generalized Bullous Fixed Drug Eruption: Case Report

Widespread bullous fixed drug eruption

A fixed dose combination of ofloxacin and ornidazole induced fixed drug eruptions

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