Widespread Foreign-Body Granulomas and Elevated Serum Angiotensin-Converting Enzyme

Pucevich, Maria V.

doi:10.1001/archderm.1983.01650270047016

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1985

2002

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“…1 Systemic sarcoidosis may present initially with such granulomatous reactions to foreign material. Multiple skin biopsies revealed a prominent infiltrate of histiocytes, many of which were multinucleated and resembled Touton cells caused an initial delay in diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Sarcoidosis with prominent giant cells

2001

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A 31-year-old man presented with a widespread papular eruption and systemic symptoms including renal colic and decreased exercise tolerance. The combination of clinical features and laboratory investigations that revealed an elevated angiotensin converting enzyme level and hypercalcaemia enabled a diagnosis of sarcoidosis to be made. Multiple skin biopsies showed prominent Touton-like giant cells which delayed the diagnosis. Giant cells are frequently seen in sarcoidal granulomas but in some cases their prominence and Touton-like appearance may suggest alternative diagnoses such as xanthogranulomas.

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Section: Discussionmentioning

confidence: 99%