The integration of the Internet of Things (IoT) technology and artificial intelligence has become essential in many aspects of daily life since the expansion of the communications and information field. Healthcare is one area that urgently needs to benefit from these technologies to keep up with the dramatic evolution of communications for contemporary human life. IoT, through wearable devices, provides real-time data related to the measurement of a person’s vital signs of health. However, for this data to become more relevant and valuable, it needs to be linked to other domains. Public transport is a domain related to the daily activity of people who take advantage of the IoT to provide exemplary transport services whose quality of service can greatly affect people’s health. The integration of these two domains offers many benefits, especially when providing services adapted to passengers’ health status, making them safer and healthier. This paper proposes an approach based on an IoT architecture using Semantic Web technologies; it aims to integrate health monitoring in public transport, provide passengers with quality transport services, and ensure continuous health monitoring. The use of Semantic Web technologies overcomes the lack of interoperability due to the heterogeneity of data collected by different devices and generated by two different domains. An experimental study was conducted, and the proposed approach’s results were compared with those obtained by the evaluation of a physician. The results show that the approach is effective and should allow passengers to benefit from appropriate transport services that better match their health status.