“Wild cannabis”: A review of the traditional use and phytochemistry of Leonotis leonurus

Nsuala, Baudry; Enslin, Gill; Viljoen, Alvaro

doi:10.1016/j.jep.2015.08.013

Cited by 33 publications

(30 citation statements)

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“…Leonotis leonurus, commonly known as the "wild dagga" in the Eastern Cape Province of South Africa, is a plant species belonging to the family of Lamiaceae and is largely distributed in the Southern Africa region (Nsuala et al 2015). In folkloric medicine, this plant has been documented to have health benefits for indigenous people around the Eastern Cape Province, South Africa (Scott et al 2004;Mazimba 2015).…”

Section: Introductionmentioning

confidence: 99%

“…The stem is commonly used to prepare an aqueous extract that is ingested for cleansing the blood of any impurities (Watt and Breyer-Brandwijk 1962). Infusions made from seeds and flowers, leaves or stems are regularly used as tonics for tuberculosis, high blood pressure, jaundice, muscular cramps, diabetes, diarrhoea, viral hepatitis and dysentery (Nsuala et al 2015). Also, L. leonurus has been reported to demonstrate anti-inflammatory, antioxidant, anti-diabetic and hepatoprotective properties (El-Ansari et al 2009;Jimoh et al 2010;Mazimba, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Chemical constituents, antioxidant and cytotoxicity properties of Leonotis leonurus used in the folklore management of neurological disorders in the Eastern Cape, South Africa

et al. 2020

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In the present study, we evaluated the phytochemical compounds and antioxidant properties of chloroform, ethanol and acetone extracts for leaves and flowers of Leonutus leonurus (L. leonurus) alongside with their cytotoxic effects on human cervical carcinoma (HeLa) cell lines. The phytochemical compounds present in the leaves and flowers of L. leonurus included; phenolics, flavonoids and alkaloids. Their radicals scavenging effects against 2, 2-diphenyl-1-picrylhydrazyl [DPPH] 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulphonate) [ABTS• + ], hydrogen peroxide, nitric oxide as well as metal chelating activities showed dose-dependent activities. Gas chromatography-mass spectrometry (GCMS) analyses revealed the presence of important bioactive compounds, which are associated with antioxidant; and the extracts exhibited toxicity effect against HeLa cells. The findings from this study divulge extracts of L. leonurus as prospective sources of antioxidant and anticancer agents; and hence, further study on their neuroprotective potentials becomes imperative.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chemical constituents, antioxidant and cytotoxicity properties of Leonotis leonurus used in the folklore management of neurological disorders in the Eastern Cape, South Africa

et al. 2020

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“…Anecdotally it is known for eliciting mild psychoactive effects akin to the smoking of Cannabis and, has a long-standing history in traditional healing practices in South Africa. Some studies have alluded to its medicinal activities however, these have largely focused on the leaves and only a few reports have dealt with the owers [10,11]. Furthermore, there are no reports that describe the occurrence of medicinal pCBs from the leaves or the owers.…”

Section: Tandem Mass Spectrometry (Lc-ms/ms) Analysesmentioning

confidence: 99%

“…1A). Since extensive phytochemical pro ling of the leaves have never yielded any pCB-like compounds [10,11], we suspected that such compounds may be present in owers (akin to Cannabis).…”

Section: Tandem Mass Spectrometry (Lc-ms/ms) Analysesmentioning

confidence: 99%

The identification of a cannabinoid-like compound (adrenoyl-EA), in the flowers of a South African medicinal plant (Leonotis leonurus)

Hunter

Stander

Koßmann

et al. 2020

Preprint

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Objective Current global trends on natural therapeutics suggest an increasing market interest toward the use and discovery of new plant-derived therapeutic compounds, often referred to as traditional medicine (TM). The Cannabis industry is currently one such focal area receiving attention, owing to the occurrence of phytocannabinoids (pCBs) which have shown promise in health-promotion and disease prevention. However, the occurrence of pCBs in other plant species are often overlooked and rarely studied. Leonotis leonurus (L.) R. Br. is endemic to South Africa with a rich history of use in TM practices amongst indigenous people and, has been recorded to induce mild psychoactive effects akin to Cannabis. While the leaves have been well-reported to contain therapeutic phytochemicals, little information exists on the flowers. Consequently, as part of a larger research venture, we targeted the flowers of L. leonurus for the identification of potential pCB or pCB-like compounds.Results Flower extracts were separated and analyzed using high performance thin layer chromatography (HPTLC). A single pCB candidate was isolated from HPTLC plates and, using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS), identified as 7,10,13,16-Docosatetraenoylethanolamine (adrenoyl-EA). Adrenoyl-EA is a known bioactive pCB-like compound reported to occur in only one other plant species, Tropaeolum tuberosum.

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“…Plants with traditional use are of interest to many scientists as it reveals their potential to be exploited to treat various diseases (van Wyk and Albrecht, 2008). Two important medicinal plants used traditionally to treat diabetes, inflammation and with an effect on the central nervous system have been investigated in this study (Albrecht et al, 2012;Nsuala et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Influence of Nitrogenous and Phosphatic Fertilizers Types and Rates on the Yield and Chemical Profile of Sutherlandia frutescens and Leonotis leonurus

Prinsloo¹,

Plooy²

2017

IJAB

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Sutherlandia frutescens and Leonotis leonurus are two important medicinal plants used traditionally to treat diabetes and inflammation harvested mainly from natural resources. The shift from subsistence to commercial trade necessitates research into cultivation, and hence information is needed for commercial production of these species. The effects of nitrogen (N) and phosphate (P) fertilizers in different forms and also at different levels on the growth and yield as well as the chemical composition were investigated. This study reported fertilizer applications' dramatic response on growth and development. The results provide a foundation for more in depth cultivation research and guidelines for soil amendment in increasing yield under field production. For L. leonurus ureum applied at 360 kg N ha-1 resulted in the highest yield. The highest yield for S. frutescens was obtained with ammonium sulphate at 360 kg N ha-1. No significant improvement in yield was obtained with P amendment for L. leonurus while S. frutescens could not survive the P trial conditions and most of the plants died. Thin layer chromatography (TLC) provided an overview of the effect of soil amendment on the chemical profile of the plants with various differences observed on the TLC plates by comparing the sample spots. Incomplete information on the active principles of both species poses various challenges in determining the effect of soil amendment on quality. These results warrant further studies into the effect of the changes in the chemical profile on the medicinal activity of the plants and specifically on target compounds.

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“Wild cannabis”: A review of the traditional use and phytochemistry of Leonotis leonurus

Cited by 33 publications

References 64 publications

Chemical constituents, antioxidant and cytotoxicity properties of Leonotis leonurus used in the folklore management of neurological disorders in the Eastern Cape, South Africa

Chemical constituents, antioxidant and cytotoxicity properties of Leonotis leonurus used in the folklore management of neurological disorders in the Eastern Cape, South Africa

The identification of a cannabinoid-like compound (adrenoyl-EA), in the flowers of a South African medicinal plant (Leonotis leonurus)

Influence of Nitrogenous and Phosphatic Fertilizers Types and Rates on the Yield and Chemical Profile of Sutherlandia frutescens and Leonotis leonurus

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