2018
DOI: 10.1111/xen.12469
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Will donor‐derived neoplasia be problematic after clinical pig organ or cell xenotransplantation?

Abstract: A search for confirmatory and more recent data revealed that, although the average lifespan of most domestic pigs is 15-27 years, [4][5][6] approximately 90% of pigs are slaughtered between 4.5 and 6 months of age as sources of food. 7,8 Hence, relatively little is known about malignancies occurring in older pigs. However, by the age of 6 months or before, the source pigs (if not miniature swine) will be of a sufficient size eg, 90 kg, for their kidneys to be transplanted into adult human recipients. As pigs w… Show more

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Cited by 3 publications
(3 citation statements)
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“…However, the incidence of colorectal cancer, which is not a virus‐induced cancer, was increased in solid cancer transplant recipients due to other medical conditions, maintenance therapy, screening practices, and immunosuppression 64 . It was speculated that the incidence of cancer in the immunocompromised recipients of xenotransplant is uncertain and most likely arise from the donor tissues; however, the lymphoid tissues from the donor may undergo uncontrolled proliferations in the recipient carrying the xenozoonotic lymphotropic viruses 65 . In addition, the pathologies leading to end‐stage organ diseases are associated with higher cancer incidence 66 .…”
Section: Selective Diseases Associated With Xenotransplantationmentioning
confidence: 99%
See 1 more Smart Citation
“…However, the incidence of colorectal cancer, which is not a virus‐induced cancer, was increased in solid cancer transplant recipients due to other medical conditions, maintenance therapy, screening practices, and immunosuppression 64 . It was speculated that the incidence of cancer in the immunocompromised recipients of xenotransplant is uncertain and most likely arise from the donor tissues; however, the lymphoid tissues from the donor may undergo uncontrolled proliferations in the recipient carrying the xenozoonotic lymphotropic viruses 65 . In addition, the pathologies leading to end‐stage organ diseases are associated with higher cancer incidence 66 .…”
Section: Selective Diseases Associated With Xenotransplantationmentioning
confidence: 99%
“…64 It was speculated that the incidence of cancer in the immunocompromised recipients of xenotransplant is uncertain and most likely arise from the donor tissues; however, the lymphoid tissues from the donor may undergo uncontrolled proliferations in the recipient carrying the xenozoonotic lymphotropic viruses. 65 In addition, the pathologies leading to end-stage organ diseases are associated with higher cancer incidence. 66 Thus, the incidence of cancer in xenotransplant recipients is a barrier in Arab countries and further studies should tackle this obstacle.…”
Section: Cancermentioning
confidence: 99%
“…Jagdale et al have written a thoughtful commentary asking if donor‐derived neoplasia affects xenotransplantation where they provide a clear discussion of the potential impacts . The commentary builds a sound case for pig‐derived neoplasia in xenotransplantation.…”
Section: Pig‐derived Neoplasia In Xenotransplantationmentioning
confidence: 99%