Willingness to Volunteer in Future Preventive HIV Vaccine Trials: Issues and Perspectives From Three U.S. Communities

Strauss, Ronald P.; Sengupta, Sohini; Kegeles, Susan M.; McLellan, Eleanor; Metzger, David S.; Eyre, Stephen L.; Khanani, Fauzia; Emrick, Catherine Boland; MacQueen, Kathleen M.

doi:10.1097/00042560-200101010-00010

Cited by 57 publications

(85 citation statements)

References 9 publications

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“…Those motivated by monetary and non-monetary incentives were more likely to be willing to participate, whereas those who indicated that no incentive would motivate them to participate were less likely. This is consistent with previous research reporting that 40-55% of IDUs would be motivated to participate in HIV vaccine research by incentives (Strauss et al, 2001). These motivating factors that drive WTP may differ in IDUs and in other risk populations, and should therefore be taken into consideration when planning sampling and recruitment methods for future vaccine trials.…”

Section: Discussionsupporting

confidence: 90%

“…Other studies have reported similar findings (Buchbinder et al, 2004;Koblin et al, 1998;Strauss et al, 2001). This highlights the importance of assessing WTP in the presence of education regarding the safety and efficacy of the vaccine, as well as risks and benefits of participation.…”

Section: Introductionsupporting

confidence: 68%

“…However, incentives alone are likely not sufficient to determine participation in a vaccine trial. Research by our group and others suggests that other factors play an important role in one's willingness to participate, such as: perception of vaccine effectiveness, fear of a positive HIV test result, operational aspects such as convenience, and vaccine safety (Buchbinder et al, 2004;Koblin et al, 1998;Meyers et al, 1994;Strauss et al, 2001;Vlahov et al, 1994).…”

Section: Discussionmentioning

confidence: 96%

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Changes in Willingness to Participate in HIV Vaccine Trials Among HIV-Negative Injection Drug Users

et al. 2005

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Injection drug users (IDUs) represent an important risk group for HIV infection. We assessed correlates of IDUs' willingness to participate (WTP) in HIV vaccine trials, and examined temporal changes in WTP. Participants were enrolled in ALIVE, a prospective study of HIV among IDUs in Baltimore; semi-annual visits include interviews and HIV serology. Questionnaires regarding WTP were administered in 1993-1994 and again in 2001-2002. Logistic regression was conducted to identify correlates of WTP. Wave 1 of the survey included 440 participants; Wave 2 included 582 participants (189 participated in both waves). WTP increased modestly over time (83.4 vs. 86.3%; p = 0.16). Monetary incentives were the strongest predictor of WTP (adjOR = 2.73; 95% CI: 1.72-4.35). High expectations of HIV treatment effectiveness did not predict WTP. In this cohort, WTP remained strong and modestly increased over the study period. These results should be considered in the planning of sampling and retention strategies for future vaccine trials.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 96%

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Changes in Willingness to Participate in HIV Vaccine Trials Among HIV-Negative Injection Drug Users

et al. 2005

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“…Freelist (FL) methodology was developed as a hybrid technique to sample terms contained within a given category (e.g., cultural domain), without imposing investigator assumptions on respondents [27,28]. This methodology allows qualitative data collection while permitting rapid, quantitative analysis and has been used to assess various aspects of HIV in diverse cultural settings [29,30]. Further, the quantitative nature of the FL allows for data to be compared across sites to gain insight on the cultural variability present.…”

mentioning

confidence: 99%

Influence of Culture on Contraceptive Utilization Among HIV-Positive Women in Brazil, Kenya, and South Africa

Todd

Stibich²,

Laher

et al. 2010

AIDS Behav

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Contraceptive choice and discontinuation are poorly understood among HIV-positive women, and HIV disease and culture may influence decisions. We assessed factors influencing contraceptive decision-making among HIV-positive women in three countries. This qualitative assessment of 108 HIV-positive women (36/site, selected by age and parity strata) was conducted in Rio de Janeiro, Brazil; Kericho, Kenya; and Soweto, South Africa. Freelist interviews assessed knowledge and attitudes towards contraception and were analyzed enumerating frequency and saliency of mentions. There was intersite consensus around list items but priority and themes varied. Site-specific factors influencing contraceptive choice were male partner wishes and fertility desire (Brazil), side-effects (South Africa), and impact on health and HIV progression (Kenya). Age, parity, and taking antiretroviral therapy (ART) impacted some themes. Contraceptive use among HIV-positive women is substantially influenced by culture and other factors. Counseling efforts should consider individual factors in method selection and offer method variety to accommodate changing needs.

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“…Freelisting is an inductive structured approach initially used in anthropology [15,16] to allow identification of relevant issues without imposing researchers' assumptions [17]. Freelisting was used here to provide a structure for asking the patients to state the concerns that they found most distressing.…”

Section: Instrumentsmentioning

confidence: 99%

Spontaneous reports of most distressing concerns in patients with inoperable lung cancer: at present, in retrospect and in comparison with EORTC-QLQ-C30+LC13

et al. 2007

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Patients with lung cancer experience considerable distress. Therefore, accurate methods for assessing distress and quality of life over time may play a key role for managing and evaluating palliative care. Alternatives to commonly used standardized questionnaires are individual measures. This study prospectively and retrospectively explored the concerns that 46 patients with inoperable lung cancer spontaneously reported as causing most distress close to diagnosis and 6 months later. Changes in content individually generated through a structured inductive freelisting were compared with EORTC-QLQ-C30+LC13 ratings. The results showed that patients perceived a wide variety of concerns as most distressing and that their concerns changed over time. Between 56 and 62% of these concerns were assessed by items included in the EORTC-QLQ-C30+LC13 questionnaires. Furthermore, patients' reports of most distress from fatigue, pain and dyspnea were not always reflected in intensity ratings of comparable EORTC-QLQ-C30+LC13 items. These results indicate that items included in standardized measures are not always adequate to assess patients' concerns, priorities and changes over time. In addition to standardized questionnaires, individualized measures may be useful in the clinical palliative setting for providing detailed information about the individual's problems and prioritizations.

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Willingness to Volunteer in Future Preventive HIV Vaccine Trials: Issues and Perspectives From Three U.S. Communities

Cited by 57 publications

References 9 publications

Changes in Willingness to Participate in HIV Vaccine Trials Among HIV-Negative Injection Drug Users

Changes in Willingness to Participate in HIV Vaccine Trials Among HIV-Negative Injection Drug Users

Influence of Culture on Contraceptive Utilization Among HIV-Positive Women in Brazil, Kenya, and South Africa

Spontaneous reports of most distressing concerns in patients with inoperable lung cancer: at present, in retrospect and in comparison with EORTC-QLQ-C30+LC13

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