Wilms' tumor protein (—KTS) modulates renin gene transcription

Steege, Andreas; Fähling, Michael; Paliege, Alexander; Bondke, Anja; Kirschner, Karin M.; Martinka, Peter; Kaps, C; Patzak, Andreas; Persson, Pontus B.; Thiele, B; Scholz, Holger; Mrowka, Ralf

doi:10.1038/ki.2008.194

Cited by 34 publications

(26 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Consistent with this notion is that WT-1 suppresses activity of the renin promoter, and might also explain why renin mRNA and protein are no longer detected when cells move in to the glomerulus to become podocytes expressing WT-1. 73 Further studies are required to validate these observations. One fact is becoming increasingly clear regarding WT-1: it is likely not a marker specific to podocytes, but rather a transcription factor that is expressed by podocytes, PECs and CoRL in the kidney under different conditions, as it is in the epicardium and lung by progenitor cells of these organs.…”

Section: Cells Of Renin Lineage As Adult Podocyte Progenitorsmentioning

confidence: 97%

Progenitor Cells and Podocyte Regeneration

Shankland¹,

Pippin²,

Duffield³

2014

Seminars in Nephrology

View full text Add to dashboard Cite

The very limited ability of adult podocytes to proliferate in vivo is clinically significant because: podocytes form a vascular barrier which is functionally critical to the nephron; podocyte hypoplasia is a characteristic of disease; and inadequate regeneration of podocytes is a major cause of persistent podocyte hypoplasia. Excessive podocyte loss or inadequate replacement leads to glomerulosclerosis in many progressive kidney diseases. Thus, restoration of podocyte cell density is almost certainly reliant on regeneration by podocyte progenitors. However such putative progenitors have remained elusive until recently. In this review we describe the developmental processes leading to podocyte and parietal epithelial cell (PEC) formation during glomerulogenesis. We compare evidence that in normal human kidneys PECs expressing ‘progenitor’ markers CD133 and CD24 can differentiate into podocytes in vitro and in vivo with evidence from animal models suggesting a more limited role of PEC-capacity to serve as podocyte progenitors in adults. We will highlight tantalizing new evidence that specialized vascular wall cells of afferent arterioles including those which produce renin in healthy kidney, provide a novel local progenitor source of new PECs and podocytes in response to podocyte hypoplasia in the adult, and draw comparisons with glomerulogenesis.

show abstract

Section: Cells Of Renin Lineage As Adult Podocyte Progenitorsmentioning

confidence: 97%

Progenitor Cells and Podocyte Regeneration

Shankland¹,

Pippin²,

Duffield³

2014

Seminars in Nephrology

View full text Add to dashboard Cite

show abstract

“…Co-localization of renin and WT1 protein has been demonstrated in rat kidney, and in transfected human embryonic kidney cell lines, overexpression of WT1 −KTS down-regulates renin expression via transcriptional repression of an upstream regulatory region. This repression effect was lost with the expression of a mutant WT1 protein [90]. Nephrin, a transmembrane receptor molecule and a constituent of the podocyte slit diaphragm, has been shown to be transcriptionally regulated by WT1, which directly binds and activates the NPHS1 promoter [91].…”

Section: Wt1 and Adult Kidneymentioning

confidence: 97%

WT1 in disease: shifting the epithelial–mesenchymal balance

Miller-Hodges

Hohenstein

2011

The Journal of Pathology

View full text Add to dashboard Cite

WT1 is a versatile gene that controls transitions between the mesenchymal and epithelial state of cells in a tissue-context dependent manner. As such, WT1 is indispensable for normal development of many organs and tissues. Uncontrolled epithelial to mesenchymal transition (EMT) is a hallmark of a diverse array of pathologies and disturbance of mesenchymal to epithelial transition (MET) has been associated with a number of developmental abnormalities. It is therefore not surprising that WT1 has been linked to many of these. Here we review the role of WT1 in proper control of the mesenchymal-epithelial balance of cells and discuss how far these roles can explain the role of WT1 in a variety of disease states.

show abstract

“…The ACE1 activity was 15-fold higher than that observed for ACE2 [18]. In addition, renin mRNA and protein can be detected in murine kidney and HEK-293 cells [19]. Therefore, it appears that Ang II can be synthesized locally.…”

mentioning

confidence: 95%

Blockade of the Renin-Angiotensin System with Delphinidin, Cyanin, and Quercetin

2012

View full text Add to dashboard Cite

Overactivation of the renin-angiotensin system is one of the most important risk factors for the development of hypertension. The use of the crude extracts and/or active compounds, such as anthocyanins and quercetin, of herbal plants that have antihypertensive effects is beneficial for decreasing of blood pressure level. However, the molecular mechanisms by which anthocyanins (delphinidin and cyanin) and quercetin regulate the renin-angiotensin system are not completely understood. In this study, we demonstrate that delphinidin, cyanin, and quercetin interrupt the renin-angiotensin system signaling pathway by inhibiting the angiotensin-converting enzyme activity and decreasing its mRNA production. Furthermore, treatment with either delphinidin or cyanin significantly inhibited renin mRNA production. However, delphinidin, cyanin, and quercetin did not act as the angiotensin II type 1 receptor antagonist and did not play roles in the regulation of its internalization. The direct inhibition of components of the renin-angiotensin system advances our understanding of the antihypertensive effects of these compounds.

show abstract

Wilms' tumor protein (—KTS) modulates renin gene transcription

Cited by 34 publications

References 57 publications

Progenitor Cells and Podocyte Regeneration

Progenitor Cells and Podocyte Regeneration

WT1 in disease: shifting the epithelial–mesenchymal balance

Blockade of the Renin-Angiotensin System with Delphinidin, Cyanin, and Quercetin

Contact Info

Product

Resources

About