Several studies have shown the capabilities of Synthetic Aperture Radar to map sea currents in ocean regions mainly characterized by large flows. We consider the well known method based on the analysis of the Doppler Centroid. The Doppler, as, in general, the scattering from the sea, is sensitive to several phenomena, occurring between the upper ocean and atmospheric boundary layers. To investigate such phenomena, we considered the combined use of both ENVISAT calibrated amplitude and Doppler data in conjunction with hindcast wind information provided by atmospheric models as well as Wind and Doppler Geophysical Model Functions (W/D-GMF) developed, in the literature, for C-Band systems. This integrated analysis for the interpretation of the Doppler surface currents measurements was carried out on a case study located in the Mediterranean Sea which is characterized by a general low circulation regime: specifically, the coastal region around the city of Naples. In this case study, we show that generally, wind plays a direct significant role in the observed Doppler surface current. The availability of an oceanographic numerical model for one of the analyzed cases also allowed us to attempt to interpret the effect of the typical thermohaline circulation pattern on the Doppler anomaly.