Wine consumption and colorectal cancer risk: a meta-analysis of observational studies

Abstract

There were inconsistent results with respect to the correlation between consumption of wine and the development of colorectal cancer (CRC). We carried out a meta-analysis to investigate this issue. We included observational studies on the aforementioned relationship according to a literature search of Embase and Pubmed from inception till 28 February 2017. The summary relative risk (SRR) and 95% confidence intervals (CI) were calculated using a random-effects model. A total of eight case–control and nine cohort studies were identified, involving 12 110 CRC cases. The study showed that wine drinking was not associated with any greater risk for CRC (SRR=0.99, 95% CI: 0.89–1.10; P heterogeneity<0.001) compared with nondrinkers. The subgroup analyses indicated that null associations were observed in men and women for colon and rectal cancer. Neither light to moderate (<2 drinks/day; SRR=0.93, 95% CI: 0.80–1.08, I 2 =69.2%) nor heavy (≥2 drinks/day; SRR=1.00, 95% CI: 0.86–1.16, I 2 =39.9%) consumption of wine was associated statistically with CRC risk. This meta-analysis suggests that any wine consumption was not associated with the risk of CRC. Null associations were shown in men and women for colon and rectal cancer.

An updated systematic review and meta-analysis on adherence to mediterranean diet and risk of cancer

“…Potential anti-tumorigenic effects of red wine are attributed to its polyphenolic content, especially resveratrol [173]. Although our results suggested a small reduction in overall cancer risk for alcohol intake within the range, compared to higher alcohol consumption, the benefit from light-to-moderate consumption of wine on cancer risk in observational studies is inconclusive [174][175][176]. Risk estimates for several cancers based on MedDiet scores including alcohol did not differ from those simply adjusted for total alcohol intake [122,[145][146][147][148][149].…”

Wine Intake in the Framework of a Mediterranean Diet and Chronic Non-Communicable Diseases: A Short Literature Review of the Last 5 Years

“…When evaluating the amount of intake, light to moderate drinkers (<2 drinks per day) showed a lower risk (SRR 0.93, 95% CI 0.80 to 1.08) than heavy drinkers (≥2 drinks per day) (SRR 1.00, 95% CI 0.86 to 1.16). Overall, no association could be found between wine consumption and the risk of colorectal cancer [121].…”

Role of Diet in Colorectal Cancer Incidence

“…Overall, the 45 meta-analyses described 109 associations, including 794 individual study estimates of CRC incidence associated with dietary exposures. The included meta-analyses provided adjusted summary estimates on the associations between dietary patterns 15,16,27,38,49,55 (13 associations), food groups [17][18][19][20][21][22][23][24][56][57][58][59] (23 associations), beverages including alcohol 25,26,[28][29][30][31][32][33] (12 associations), macronutrients [34][35][36][37]39,40,49,59 (18 associations), and micronutrients [41][42][43][44][45][46][47][48][50][51][52][53][54] (43 associations) and the incidence of CRC. Definitions of dietary patterns is provided in the eAppendix in the Supplement.…”