Wireless Capsule Endoscopy in Children: A Study to Assess Diagnostic Yield in Small Bowel Disease in Paediatric Patients

Thomson, Mike; Fritscher-Ravens, Annette; Mylonaki, Maria; Swain, Paul; Eltumi, Muftah; Heuschkel, Robert; Murch, Simon; McAlindon, Mark E.; Furman, M

doi:10.1097/01.mpg.0000252196.91707.ff

Cited by 97 publications

(86 citation statements)

References 36 publications

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“…Most SBCE studies included patients who had negative colonoscopies and SBFT [108,117]. Thomson et al [114] showed that SBCE is more sensitive for small-bowel pathology than SBFT (out of 19 children who had abnormalities on SBCE, only 5 had abnormal results at SBFT) and than upper intestinal endoscopy with ileocolonoscopy (only 10 had endoscopic findings compared with 23 at SBCE). Data from paediatric case series suggests that SBCE is superior to SBFT/SBE for detecting small-bowel pathology.…”

Section: How Does Sbce Compare With Other Imaging Modalities In Paedimentioning

confidence: 99%

Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED–ECCO consensus

Bourreille¹,

Ignjatovic²,

Aabakken³

et al. 2009

Endoscopy

304

185

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Section: How Does Sbce Compare With Other Imaging Modalities In Paedimentioning

confidence: 99%

Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED–ECCO consensus

Bourreille¹,

Ignjatovic²,

Aabakken³

et al. 2009

Endoscopy

304

185

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“…The technique is approved by the FDA for use in children ≥2 years of age 34 and safe use has been demonstrated in infants as young as 10 months 35 . Capsules are inherently less invasive than standard endoscopes as they move through the body via natural motion induced by peristalsis rather than being manually manoeuvred by the clinician.…”

Section: Biomarkers For Eedmentioning

confidence: 99%

The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction

Thompson

Hughes

Anastasova

et al. 2017

Nat Rev Gastroenterol Hepatol

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| Environmental enteric dysfunction (EED) is a disease of the small intestine affecting children and adults in low and middle income countries. Arising as a consequence of repeated infections, gut inflammation results in impaired intestinal absorptive and barrier function, leading to poor nutrient uptake and ultimately to stunting and other developmental limitations. Progress towards new biomarkers and interventions for EED is hampered by the practical and ethical difficulties of cross-validation with the gold standard of biopsy and histology. Optical biopsy techniques -which can provide minimally invasive or noninvasive alternatives to biopsy -could offer other routes to validation and could potentially be used as point-of-care tests among the general population. This Consensus Statement identifies and reviews the most promising candidate optical biopsy technologies for applications in EED, critically assesses them against criteria identified for successful deployment in developing world settings, and proposes further lines of enquiry. Importantly, many of the techniques discussed could also be adapted to monitor the impaired intestinal barrier in other settings such as IBD, autoimmune enteropathies, coeliac disease, graft-versus-host disease, small intestinal transplantation or critical care. Members of the board and experts met to discuss the horizon scan in London, UK, in November 2015 and San Francisco, USA, in February 2016. Literature searches were performed using Web of Science, as well as through the advice of the advisory board and experts. The results of the horizon scan are presented in this Consensus Statement, which entails a review of EED, a discussion of technologies deemed relevant to EED (based on literature searches and the opinions of the advisory board and experts), and a series of recommendations for the future application of the rele vant technologies to the study and diagnosis of EED. In the Recommendations section, each technology has been assessed according to its suitability for application to EED and this assessment includes an evaluation of the cost, invasiveness and appropriateness for developing countries of each device and/or technique. This assessment was performed in a qualitative manner based on currently available information (for example, the present cost and size of the devices) and the opinions of the authors as to feasible future develop ment. Technique suitability for use in developing countries was determined in a qualitative manner after consideration of the need for advanced infrastructure and high levels of training for either system use or data analysis. Probable deployment time scales have also been assigned to each technique based on the current states of development and the degree of valid ation work that will be required before application to EED. These timescales have been tentatively defined as short-term (suitable for deployment immediately or within ~1 year), mediumterm (suit able for deployment within ~1-3 years) and long-term (suitable for deployme...

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“…Because a known CD increases a risk of capsule retention possibly caused by an intestinal stricture (Cheifetz, 2006;Moy, 2009;Atay, 2009), it is recommended to avoid the use of CE for the evaluation of known CD in both adult and children. In regard to the diagnostic accuracy, the previous pediatric study elucidated that CE was a more effective diagnostic tool in established CD patients compared with small-bowel radiography, CTE, and push enteroscopy (Thomson, 2007). Further, CE provides evidence not only to diagnose a patient having CD but also exclude CD and discriminate CD from indeterminate colitis.…”

Section: Chron's Disease or Inflammatory Bowel Diseasementioning

confidence: 99%

“…Another pediatric study described that 6/12 patients with abdominal pain had abnormal findings in which 3 with small bowel CD, 2 lymph nodular hyperplasia, and 1 blue rubber bleb syndrome, however it is undescribed whether those patients had additional symptoms or signs (Fritscher-Ravens, 2009). CE evaluation for a patient with recurrent abdominal pain reported a self-resolving ileojejunal intussusceptions in the mid-small bowel (Thomson, 2007). Taken together, as well as adult patients, it is indicated that CE doesn't provide diagnostic value against abdominal pain in children, but additional symptoms or signs may increase the demand of CE.…”

Section: Abdominal Painmentioning

confidence: 99%

“…As well as adult patients, CE is more sensitive than radiological and standard endoscopic modalities in the detection of small bowel CD distribution, OGIB source, and presence of polyps in children (Thomson, 2007;Guilhon de Araujo Sant'Anna, 2005). In addition, because of its non-invasive approach, even if initial study is non-diagnostic, repeat CE may increase diagnostic yield (Tokuhara, 2010).…”

Section: Comparison With Other Modalitiesmentioning

confidence: 99%

See 1 more Smart Citation

Wireless Capsule Endoscopy in Pediatric Gastrointestinal Diseases

Tokuhara¹

2011

New Techniques in Gastrointestinal Endoscopy

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Wireless Capsule Endoscopy in Children: A Study to Assess Diagnostic Yield in Small Bowel Disease in Paediatric Patients

Cited by 97 publications

References 36 publications

Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED–ECCO consensus

Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED–ECCO consensus

The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction

Wireless Capsule Endoscopy in Pediatric Gastrointestinal Diseases

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