Wireless, In Vivo Neural Recording using a Custom Integrated Bioamplifier and the Pico System

Cheney, David; Goh, Aik; Xu, Jie; Gugel, K.; Harris, John G.; Sanchez, Justin C.; Prı́ncipe, José C.

doi:10.1109/cne.2007.369601

Cited by 11 publications

(8 citation statements)

References 15 publications

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“…used a commercial ASK/OOK transceiver at 1 Mb/s from RF Monolithics (Dallas, TX, USA) for their 96-ch system [19], while Cheney et al . used a commercial 2.4-GHz FSK transceiver at 1 Mb/s from Nordic Semiconductor (Trondheim, Norway) for their 16-ch system [20]. High data rate digital systems require frequency stabilization components, such as crystals and phase-locked loops (PLL), to reduce the phase noise and ensure proper synchronization between Tx and Rx, which can increase the size and power consumption of the Tx.…”

Section: Introductionmentioning

confidence: 99%

A Wideband Dual-Antenna Receiver for Wireless Recording From Animals Behaving in Large Arenas

Lee

Yin

Manns

et al. 2013

IEEE Trans. Biomed. Eng.

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A low-noise wideband receiver (Rx) is presented for a multichannel wireless implantable neural recording (WINeR) system that utilizes time-division multiplexing of pulse width modulated (PWM) samples. The WINeR-6 Rx consists of four parts: 1) RF front end; 2) signal conditioning; 3) analog output (AO); and 4) field-programmable gate array (FPGA) back end. The RF front end receives RF-modulated neural signals in the 403–490 MHz band with a wide bandwidth of 18 MHz. The frequency-shift keying (FSK) PWM demodulator in the FPGA is a time-to-digital converter with 304 ps resolution, which converts the analog pulse width information to 16-bit digital samples. Automated frequency tracking has been implemented in the Rx to lock onto the free-running voltage-controlled oscillator in the transmitter (Tx). Two antennas and two parallel RF paths are used to increase the wireless coverage area. BCI-2000 graphical user interface has been adopted and modified to acquire, visualize, and record the recovered neural signals in real time. The AO module picks three demultiplexed channels and converts them into analog signals for direct observation on an oscilloscope. One of these signals is further amplified to generate an audio output, offering users the ability to listen to ongoing neural activity. Bench-top testing of the Rx performance with a 32-channel WINeR-6 Tx showed that the input referred noise of the entire system at a Tx–Rx distance of 1.5 m was 4.58 μVrms with 8-bit resolution at 640 kSps. In an in vivo experiment, location-specific receptive fields of hippocampal place cells were mapped during a behavioral experiment in which a rat completed 40 laps in a large circular track. Results were compared against those acquired from the same animal and the same set of electrodes by a commercial hardwired recording system to validate the wirelessly recorded signals.

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Section: Introductionmentioning

confidence: 99%

A Wideband Dual-Antenna Receiver for Wireless Recording From Animals Behaving in Large Arenas

Lee

Yin

Manns

et al. 2013

IEEE Trans. Biomed. Eng.

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“…Several sophisticated designs have been demonstrated at the benchtop level including approaches for circuit integration on a single wafer [29]–[35]. To date, however, much of such integrated ASIC-based engineering work is still awaiting for successful transition to in vivo use, especially for primate research.…”

Section: Compacting “Neuroelectronics”—towards Portable and Wearamentioning

confidence: 99%

“…Here we review one successful transition through the work of Shenoy, Harrison, and colleagues who have developed wireless, atop-head-mounted modules for freely moving monkeys through several stages on miniaturization [36]–[39]. We note that related exterior, headmounted systems, albeit at more modest level of performance, have been developed in recent years for freely moving rodents [31], [35], [41], [42]. …”

Section: Compacting “Neuroelectronics”—towards Portable and Wearamentioning

confidence: 99%

Listening to Brain Microcircuits for Interfacing With External World—Progress in Wireless Implantable Microelectronic Neuroengineering Devices

et al. 2010

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Acquiring neural signals at high spatial and temporal resolution directly from brain microcircuits and decoding their activity to interpret commands and/or prior planning activity, such as motion of an arm or a leg, is a prime goal of modern neurotechnology. Its practical aims include assistive devices for subjects whose normal neural information pathways are not functioning due to physical damage or disease. On the fundamental side, researchers are striving to decipher the code of multiple neural microcircuits which collectively make up nature’s amazing computing machine, the brain. By implanting biocompatible neural sensor probes directly into the brain, in the form of microelectrode arrays, it is now possible to extract information from interacting populations of neural cells with spatial and temporal resolution at the single cell level. With parallel advances in application of statistical and mathematical techniques tools for deciphering the neural code, extracted populations or correlated neurons, significant understanding has been achieved of those brain commands that control, e.g., the motion of an arm in a primate (monkey or a human subject). These developments are accelerating the work on neural prosthetics where brain derived signals may be employed to bypass, e.g., an injured spinal cord. One key element in achieving the goals for practical and versatile neural prostheses is the development of fully implantable wireless microelectronic “brain-interfaces” within the body, a point of special emphasis of this paper.

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“…Such sensitivities can compromise data as posture and position of the animal can alter the properties of the received signal. More recently, digital systems with onboard data storage or digital wireless transmission with error checking have been employed across animal models, from insect [44, 45] to rodent [46, 47] to primate [24, 48–50]. …”

Section: Introductionmentioning

confidence: 99%

Autonomous head-mounted electrophysiology systems for freely behaving primates

Gilja¹,

Chestek²,

Nuyujukian³

et al. 2010

Current Opinion in Neurobiology

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Recent technological advances have led to new lightweight battery-operated systems for electrophysiology. Such systems are head mounted, run for days without experimenter intervention, and can record and stimulate from single or multiple electrodes implanted in a freely-behaving primates. Here we discuss existing systems, studies that use them, and how they can augment traditional, physically restrained, “in-rig” electrophysiology. With existing technical capabilities these systems can acquire multiple signal classes, such as spikes, local field potential, and electromyography signals, and can stimulate based on real-time processing of recorded signals. Moving forward, this class of technologies, along with advances in neural signal processing and behavioral monitoring, have the potential to dramatically expand the scope and scale of electrophysiological studies.

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Wireless, In Vivo Neural Recording using a Custom Integrated Bioamplifier and the Pico System

Cited by 11 publications

References 15 publications

A Wideband Dual-Antenna Receiver for Wireless Recording From Animals Behaving in Large Arenas

A Wideband Dual-Antenna Receiver for Wireless Recording From Animals Behaving in Large Arenas

Listening to Brain Microcircuits for Interfacing With External World—Progress in Wireless Implantable Microelectronic Neuroengineering Devices

Autonomous head-mounted electrophysiology systems for freely behaving primates

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