Wireless MRI‐Powered Reversible Orientation‐Locking Capsule Robot

Erin, Önder; Boyvat, Mustafa; Lazović, Jelena; Tiryaki, Mehmet; Sitti, Metin

doi:10.1002/advs.202100463

Cited by 22 publications

(15 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MR observations of the actuator are presented in Figure 3b. Continuing this effort, in 2021, Erin et al proposed a capsule robot that is not only imaged but also powered by a MRI machine [79,80]. The robot demonstrated steerable navigation, medical function, and MRI tracking capabilities inside a preclinical small-animal MRI machine, which wirelessly powered and monitored the robot.…”

Section: Small-scale Magnetic Robotic Systems With Mrimentioning

confidence: 99%

“…Micro/nanorobot with a ferromagnetic core In vitro and in vivo with tortuous phantom and animal models 2008 [71] Flagellated magnetotactic bacterium Carotid artery of a living swine 2009 [72,73] Ferromagnetic catheter Renal arteries of rabbits 2015 [77] Biohybrid helical microswimmers Rodent stomachs 2017 [75] Millirobot Silicone oil pool in a square clear container 2019 [78] Millimetre-scale Lorentz force actuator module A square clear plastic container 2020 [74] Centermetre-scale capsule reversible orientation-locking robot (REVOLBOT) A synthetic maze embedded in a phosphate-buffered saline (PBS) solution 2021 [79,80] Neutrophil-based microrobot ("neutrobot")…”

Section: Small-scale Magnetic Robot Workpace Referencementioning

confidence: 99%

See 1 more Smart Citation

Evolving from Laboratory Toys towards Life-Savers: Small-Scale Magnetic Robotic Systems with Medical Imaging Modalities

Zhang

2021

Micromachines

View full text Add to dashboard Cite

Small-scale magnetic robots are remotely actuated and controlled by an externally applied magnetic field. These robots have a characteristic size ranging from several millimetres down to a few nanometres. They are often untethered in order to access constrained and hard-to-reach space buried deep in human body. Thus, they promise to bring revolutionary improvement to minimally invasive diagnostics and therapeutics. However, existing research is still mostly limited to scenarios in over-simplified laboratory environment with unrealistic working conditions. Further advancement of this field demands researchers to consider complex unstructured biological workspace. In order to deliver its promised potentials, next-generation small-scale magnetic robotic systems need to address the constraints and meet the demands of real-world clinical tasks. In particular, integrating medical imaging modalities into the robotic systems is a critical step in their evolution from laboratory toys towards potential life-savers. This review discusses the recent efforts made in this direction to push small-scale magnetic robots towards genuine biomedical applications. This review examines the accomplishment achieved so far and sheds light on the open challenges. It is hoped that this review can offer a perspective on how next-generation robotic systems can not only effectively integrate medical imaging methods, but also take full advantage of the imaging equipments to enable additional functionalities.

show abstract

Section: Small-scale Magnetic Robotic Systems With Mrimentioning

confidence: 99%

Section: Small-scale Magnetic Robot Workpace Referencementioning

confidence: 99%

Evolving from Laboratory Toys towards Life-Savers: Small-Scale Magnetic Robotic Systems with Medical Imaging Modalities

Zhang

2021

Micromachines

View full text Add to dashboard Cite

show abstract

“…However, the localization of these miniature robots in the human body remains a significant challenge for future medical applications. [ 28,29 ] The researchers have adapted various medical imaging techniques [ 30 ] for localizing them, such as magnetic resonance imaging (MRI), [ 4,5,8–12 ] ultrasound imaging, [ 20,31–33 ] X‐ray imaging, [ 6 ] positron emission tomography, [ 34 ] optoacoustic imaging, [ 35,36 ] and magnetic particle imaging. [ 37,38 ]…”

Section: Introductionmentioning

confidence: 99%

“…

Wireless miniature magnetic robots have the potential to reshape the traditional understanding of minimally invasive medical operations with their ability to access hard-to-reach, unprecedented, and risky regions in the human body. [1,2] A wide variety of magnetic locomotion methods, such as magnetic gradient pulling, [3][4][5][6][7][8][9][10][11][12][13][14][15] helical swimming, [16][17][18][19] soft-bodied locomotion, [20][21][22][23] undulatory swimming, [24,25] and surface rolling, [26,27] would make it possible to navigate these robots in regions like the gastrointestinal (GI) tract, urinary system, reproductive system, eye cavity, abdominal cavities, brain ventricles, and the vascular system. However, the localization of these miniature robots in the human body remains a significant challenge for future medical applications.

…”

mentioning

confidence: 99%

“…However, the localization of these miniature robots in the human body remains a significant challenge for future medical applications. [28,29] The researchers have adapted various medical imaging techniques [30] for localizing them, such as magnetic resonance imaging (MRI), [4,5,[8][9][10][11][12] ultrasound imaging, [20,[31][32][33] X-ray imaging, [6] positron emission tomography, [34] optoacoustic imaging, [35,36] and magnetic particle imaging. [37,38] Among these imaging modalities, MRI attracts special attention due to its ionizing radiation-free nature and its superior image resolution of soft tissues compared with the other modalities.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Magnetic Resonance Imaging‐Based Tracking and Navigation of Submillimeter‐Scale Wireless Magnetic Robots

Tiryaki

Sitti

2021

Advanced Intelligent Systems

Self Cite

View full text Add to dashboard Cite

Magnetic resonance imaging (MRI) scanners have recently been used for magnetic actuation of robots for minimally invasive medical operations. Due to MRI's high soft‐tissue selectivity, it is possible to obtain 3D images of hard‐to‐reach cavities in the human body, where the wireless miniature magnetic robots powered by MRI could be employed for high‐precision targeted operations, such as drug delivery, stem cell therapy, and hyperthermia. However, the state‐of‐the‐art fast magnetic robot‐tracking methods in MRI are limited above millimeter‐size scale, which restricts the potential target regions inside the human body. Herein, a fast 1D projection‐based MRI approach that can track magnetic particles down to 300 μm diameter (1.17 × 10−2 emu) is reported. The technique reduces the trackable magnetic particle size in MRI‐powered navigation fivefold compared with the previous fast‐tracking methods. A closed‐loop MRI‐powered navigation with 0.78 ± 0.03 mm trajectory‐following accuracy in millimeter‐sized in vitro 2D channels and a 3D cavity setup using the tracking method is demonstrated. Furthermore, the feasibility of submillimeter magnetic robot tracking in ex vivo pig kidneys (N = 2) with a 3.6 ± 1.1 mm accuracy is demonstrated. Such a fast submillimeter‐scale mobile robot‐tracking approach can unlock new opportunities in minimally invasive medical operations.

show abstract

Decoupling and Reprogramming the Wiggling Motion of Midge Larvae Using a Soft Robotic Platform

Xia

Jin

et al. 2022

Advanced Materials

View full text Add to dashboard Cite

these natural modes of locomotion with engineered systems has been challenging. [11][12][13] In this respect, burgeoning effort has been devoted to developing new simulation tools, physical models, and experimental platforms. Among these engineering tools, soft robotic systems are promising in light of their biologically relevant mechanical compliance, deformability, and modes of locomotion. [4,[14][15][16][17] Untethered soft robots, which can freely move without requiring a physical connection to external hardware and power supplies, are good candidates for studying the locomotion modes of natural invertebrates. [18][19][20][21] Thanks to recent advances in fabrication methods, [22][23][24][25][26] functional materials, [27][28][29] and actuation strategies, [7,[30][31][32][33][34][35] roboticists have proposed several soft robots that are capable of mimicking some features of natural animal locomotion. For example, previous efforts with photo-responsive hydrogels-based robots demonstrated the ability to mimic peristaltic earthworm crawling. [36] Likewise, untethered soft robots powered with shape memory alloy have been shown to exhibit a variety of locomotion modes, including undulation, jumping, crawling through narrow space or walking over rough terrain. [37,38] The application of magnetic soft robots in biomimetic study has received growing attention due to their high controllability. Hu et al. developed a millimeter-scale film robot that achieves multiple locomotion modes,The efficient motility of invertebrates helps them survive under evolutionary pressures. Reconstructing the locomotion of invertebrates and decoupling the influence of individual basic motion are crucial for understanding their underlying mechanisms, which, however, generally remain a challenge due to the complexity of locomotion gaits. Herein, a magnetic soft robot to reproduce midge larva's key natural swimming gaits is developed, and the coupling effect between body curling and rotation on motility is investigated. Through the authors' systematically decoupling studies using programmed magnetic field inputs, the soft robot (named LarvaBot) experiences various coupled gaits, including biomimetic side-to-side flexures, and unveils that the optimal rotation amplitude and the synchronization of curling and rotation greatly enhance its motility. The LarvaBot achieves fast locomotion and upstream capability at the moderate Reynolds number regime. The soft robotics-based platform provides new insight to decouple complex biological locomotion, and design programmed swimming gaits for the fast locomotion of softbodied swimmers.

show abstract

Wireless MRI‐Powered Reversible Orientation‐Locking Capsule Robot

Cited by 22 publications

References 40 publications

Evolving from Laboratory Toys towards Life-Savers: Small-Scale Magnetic Robotic Systems with Medical Imaging Modalities

Evolving from Laboratory Toys towards Life-Savers: Small-Scale Magnetic Robotic Systems with Medical Imaging Modalities

Magnetic Resonance Imaging‐Based Tracking and Navigation of Submillimeter‐Scale Wireless Magnetic Robots

Decoupling and Reprogramming the Wiggling Motion of Midge Larvae Using a Soft Robotic Platform

Contact Info

Product

Resources

About