Wirkung nachtr�glicher Hypophysektomie auf den Eintritt der Nebennierenrindensch�den bei Diphtherietoxinvergiftung

Tonutti, E

doi:10.1007/bf01481104

Cited by 19 publications

(2 citation statements)

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“…Contrary to our results, hypophysectomy prevents adrenal necrosis induced in experimental animals by diphtheria toxin [28], 7,12-dimethylbenz(a)anthracene [5], hexadimethrine bromide [14], acrylonitrile [26], thioguaninc and thioacetamide [18,27].…”

Section: Discussioncontrasting

confidence: 69%

The experimental production of hemorrhagic lesions in the rat adrenal, liver and lung by basic polyglutamic acid derivatives

1972

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Section: Discussioncontrasting

confidence: 69%

The experimental production of hemorrhagic lesions in the rat adrenal, liver and lung by basic polyglutamic acid derivatives

1972

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“…Roux and Yersin (3) in their classic paper on diphtheria toxin, described redness in the adrenal glands of guinea pigs whose mucous membranes had been excoriated and inoculated with diphtheria bacilli. Tonutti (4) found that lethal doses of diphtheria toxin caused edema, hemorrhage, and necrosis of the adrenal cortex of normal guinea pigs; but if hypophysectomy were performed either just before, or up to 11 hours after the administration of the toxin, the adrenals were spared from toxic damage (5).…”

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confidence: 99%

SELECTIVE ADRENAL NECROSIS AND APOPLEXY INDUCED BY 7,12-DIMETHYLBENZ(a)ANTHRACENE

Huggins

Morii

1961

The Journal of Experimental Medicine

162

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In the work now to be described, it was observed that a single dose of 7,12-dimethylbenz(a)anthracenO caused extraordinary changes in the rat consisting of adrenal apoplexy and massive necrosis in the two inner zones of the cortex while other regions of the adrenal glands were uninjured. In addition to the selectivity of the anatomic site of damage, there is high specificity of the molecular structure of the polynuclear aromatic hydrocarbon exerting this adrenocortieolyfic effect.Earlier it was found (1, 2) that a single dose of any of a number of polynuclear aromatic hydrocarbons, under special circumstances, selectively induced mammary cancer in every rat with very great rapidity. DMBA was the most effective of these compounds and tumors arose following a solitary feeding or an intravenous injection. At necropsy of rats with cancer of the breast induced by a solitary dose of DMBA which had been administered a few weeks previously, it was observed that the adrenal glands of most of the animals were calcified. The adrenals of rats bearing mammary cancer induced by hydrocarbons other than DMBA were not calcified. It was soon found that adrenal apoplexy and necrosis were produced invariably with DMBA soon after giving the hydrocarbon. This is a newly recognized property of DMBA.Several methods were employed in these experiments for detection and measurement of damage to the adrenal glands. These included: (a) direct inspection of the gland; (b) histological observation; (c) estimation of the amount of blood pigments; (d) determination of enzyme content of the adrenals; (e) roentgenologic detection of adrenal calcification.

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Die kindlichen Nebennieren und ihre Pathologie

Dhom

1965

Die Nebennierenrinde Im Kindesalter

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Wirkung nachtr�glicher Hypophysektomie auf den Eintritt der Nebennierenrindensch�den bei Diphtherietoxinvergiftung

Cited by 19 publications

References 1 publication

The experimental production of hemorrhagic lesions in the rat adrenal, liver and lung by basic polyglutamic acid derivatives

The experimental production of hemorrhagic lesions in the rat adrenal, liver and lung by basic polyglutamic acid derivatives

SELECTIVE ADRENAL NECROSIS AND APOPLEXY INDUCED BY 7,12-DIMETHYLBENZ(a)ANTHRACENE

Die kindlichen Nebennieren und ihre Pathologie

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