Wirkung von Molsidomin auf die Hämodynamik in Ruhe und unter Belastung bei Patienten mit koronarer Herzkrankheit

Niehues, B; Krimmel, W; Hombach, Vinzenz; Tauchert, M.; Behrenbeck, D. W.; Hilger, H H

doi:10.1055/s-0028-1104774

Cited by 10 publications

(3 citation statements)

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“…Animal experiments (8,11,15,29) and clinical studies (5,19,20,(25)(26)(27) demonstrated that the reduction of intramyocardial wall tension due to lowered preload is the main therapeutic principle of the drug. Because of the documented long duration of its antianginal and venodilating action molsidomine may be a promising candidate for pharmacological prophylaxis of anginal attacks.…”

Section: Discussionmentioning

confidence: 99%

Increased effective vascular compliance and venous pooling of intravascular volume during sustained venodilation in conscious dogs

et al. 1981

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The hemodynamic effects of the long-acting antianginal drug molsidomine were studied in 8 chronically instrumented conscious dogs by measuring the partition of the intravascular volume and the effective compliance of the total vascular bed. The blood volume of the resting dogs was varied by +/- 4 ml/kg in a cycle of blood infusion, withdrawal and reinfusion within 12 minutes. Relating the observed alterations in mean right atrial pressure to the induced changes in intravascular volume, an effective compliance of 2.9 +/- 0.4 ml. mm Hg-1 . kg -1 (mean +/- SD) was found. Heart rate, total peripheral vascular resistance and the local capacity of the distal femoral vein did not change significantly during the cycle of volume alterations. Following 0.1 mg/kg molsidomine i.v., mean right atrial pressure was lowered by 1.6 mm Hg and mean left atrial pressure by 3.4 mm Hg; the effective compliance was elevated to 4.7 +/- 0.6 ml . mm Hg-1. kg -1 (p less than 0.001), and the central blood volume was lowered from 17.8 +/- 3.1 to 14.8 +/0 3.3 ml/kg (p less than 0.01), while the total blood volume remained constant. The decline in stroke volume and the reflexly induced increase in heart rate correlated with the control heart rate. Mean arterial pressure declined from 101 +/- 7 to 91 +/- 14 mm Hg (p less than 0.05) and total peripheral vascular resistance remained unaffected. It is concluded that molsidomine exerts exerts its hypotensive effect by dilation within the vascular low-pressure system and that this dilation can be described quantitatively in conscious animals by the analysis of the total effective vascular compliance.

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Section: Discussionmentioning

confidence: 99%

Increased effective vascular compliance and venous pooling of intravascular volume during sustained venodilation in conscious dogs

et al. 1981

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“…Molsidomine has been shown to be an effective agent in the treatment of angina pectoris (Blazek et a/., 1977;Jansen and Klepzig, 1978;Majid e(a/., 1980). In previous studies reduction of myocardial ischemia by treatment with molsidomine was demonstrated by clinical relief of symptoms and by electrocardiographic and hemodynamic response to exercise (Grewe and Stauch, 1977;Niehues et a/., 1978;Slany et a/., 1976). The basic mode of action is a reduction of left ventricular wall tension, primarily by the venodilator capacity of the drug (Majid et a/., 1980).…”

Section: Introductionmentioning

confidence: 94%

“…The basic mode of action is a reduction of left ventricular wall tension, primarily by the venodilator capacity of the drug (Majid et a/., 1980). Studies in animals Grund et a/., 1978; and in men (Majid et a/., 1980;Niehues et a/., 1978) have shown that the drug-induced hemodynamic changes are similar to those of nitrates, but therapeutic effectiveness seems to be longer lasting (Hashimoto et al, 1971;Takeshita et al, 1977). Although nitroglycerin and other nitrates have been extensively employed in the treatment of angina pec-W. Nechwatal el al.…”

Section: Introductionmentioning

confidence: 99%

Effects of molsidomine on global and regional left ventricular function at rest and during exercise in patients with angina pectoris

Nechwatal

Stauch

Sigel

et al. 1981

Clinical Cardiology

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Summary: Although the antianginal properties of molsidomine are well-established, little is known about its effects on global and regional left ventricular dysfunction secondary to myocardial ischemia. In the present study, left ventricular performance was assessed by radionuclide ventriculography at rest and during exercise in 15 patients with coronary artery disease (CAD) and angina pectoris before and after the administration of 2 mg molsidomine sublingually. Gated blood pool studies were performed for evaluation of left ventricular ejection fraction (LVEF) and regional wall motion by analyzing amplitudes and phases of the first Fourier coefficient of regional time-activity curves.In contrast to normal subjects, during the control study period L VEF in patients with CAD decreased from 50.9% at rest to 42.7% during exercise (pO.lO).In conclusion, assessment of left ventricular performance at rest and during exercise in patients with CAD revealed significant improvement of global and regional left ventricular function, indicating reduction of myocardial ischemia. These effects may result primarily from reduction of left ventricular wall tension.

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Pathophysiological aspects of predominant preload lowering on pulmonary circulation, gas exchange, and the biventricular function in patients with chronic obstructive lung disease

Seibold¹,

Bunjes²,

Schmidt³

et al. 1988

Clinical Cardiology

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Summary:A group of 21 patients with various degrees of chronic obstructive pulmonary disease underwent radionuclide ventriculography with hemodynamic monitoring to assess the extent to which pulmonary artery pressures and pulmonary vascular resistance can be lowered by the vasodilator molsidomine. Molsidomine (N-carboxy-3-morpholino-sydnonimin-ethylester) is similar to nitroglycerin in its mode of action. After hemodynamic and radionuclide data acquisition, at rest and during submaximal exercise in the steady state, 2 mg molsidomine was injected intravenously. Rest and exercise measurements were repeated 45 min after molsidomine injection. In patients with mild to moderate disease (group l), pulmonary artery resting pressures decreased by 12% (~~0 . 0 5 ) at rest and by 22% (p

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Wirkung von Molsidomin auf die Hämodynamik in Ruhe und unter Belastung bei Patienten mit koronarer Herzkrankheit

Cited by 10 publications

References 0 publications

Increased effective vascular compliance and venous pooling of intravascular volume during sustained venodilation in conscious dogs

Increased effective vascular compliance and venous pooling of intravascular volume during sustained venodilation in conscious dogs

Effects of molsidomine on global and regional left ventricular function at rest and during exercise in patients with angina pectoris

Pathophysiological aspects of predominant preload lowering on pulmonary circulation, gas exchange, and the biventricular function in patients with chronic obstructive lung disease

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