Witamina D jako związek o działaniu plejotropowym – przegląd aktualnych badań

Szeja, Nicola

doi:10.21164/pomjlifesci.347

Cited by 4 publications

(8 citation statements)

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“…Many studies show that 80% to 90% of vitamin D comes from the synthesis of 7-dehydrocholesterol present in the skin. The second are exogenous sources: food products and dietary supplements [10]. Food can provide no more than 30% of the daily vitamin D requirement [2].…”

Section: Sources Of Vitamin Dmentioning

confidence: 99%

“…In the event of a reduced supply of vitamin D, the body can use the reserves accumulated there. However, these resources cannot be used over a longer period because they are limited and last only a few months [10].…”

Section: Diseases Related To Excess Of Vitamin Dmentioning

confidence: 99%

“…Moreover, deficiencies may result from reduced bioavailability of vitamin D from the gastrointestinal tract, which may result in malabsorption and impaired metabolism as well as inability to use vitamin D reserves accumulated in adipose tissue in obese people (vitamin D sequestration in adipose tissue) [34]. Examples of diseases associated with malabsorption include celiac disease, inflammatory bowel disease (e.g., Leśniowski-Crohn disease, ulcerative colitis), and liver and pancreatic diseases (e.g., in people with cystic fibrosis) [10].…”

Section: Vitamin Deficiencymentioning

confidence: 99%

“…Many studies have shown a relationship between vitamin D deficiency and the occurrence of certain cancers in the human body. Among them there are, for example, cancers of the colon, prostate, nipple, breast, as well as cancers of the bladder, head, neck, and lungs [10]. Epidemiological studies have reported lower incidence and mortality rates from several cancers in regions with higher solar exposure.…”

Section: Cancersmentioning

confidence: 99%

“…Numerous studies confirm insufficient vitamin D levels in Alzheimer patients compared to the control group [10,12]. Studies on the effects of vitamin D on the development of Alzheimer disease indicate that this hormone is a neurosteroid that may be important in the aging process and in age-related cognitive decline.…”

Section: Neurodegenerative Diseasesmentioning

confidence: 99%

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Health consequences of vitamin D deficiency in the human body

Glibowski

Iłowiecka

Środek

2021

Postępy Higieny I Medycyny Doświadczalnej

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Vitamin D is extremely important for the proper functioning of the body. The most commonly known role of vitamin D is its participation in regulation of calcium-phosphate metabolism and bone mineralization. This role is crucial in the prevention of rickets in children and osteoporosis in the elderly. In recent years, numerous studies have confirmed the pleiotropic effects of vitamin D. Proper vitamin D levels in blood have a positive effect on overall health, thus reducing the risk of many diseases. Vitamin D plays, inter alia, a positive role in some diseases of the gastrointestinal tract (inflammatory bowel disease), nervous system (Parkinson disease, Alzheimer disease), and cardiovascular disease (atherosclerosis). Additionally, its positive protective effect in the case of neoplastic and immunological diseases has been noted. Some studies also confirm the relationship of vitamin D deficiency to obesity and depression. In the event of these diseases, it is possible to prevent disease and support the process of treatment by maintaining appropriate levels of 25(OH)D in the blood. Besides, sufficient blood vitamin D levels reduces the risk of developing respiratory tract infections and suppresses cytokine storm, which is responsible for most COVID-19 deaths. The aim of the study was to present the current state of knowledge regarding the role of vitamin D in the human body, especially in the context of the impact of its abnormal level on the development of various diseases.

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Section: Sources Of Vitamin Dmentioning

confidence: 99%

Section: Diseases Related To Excess Of Vitamin Dmentioning

confidence: 99%

Section: Vitamin Deficiencymentioning

confidence: 99%

Section: Cancersmentioning

confidence: 99%

Section: Neurodegenerative Diseasesmentioning

confidence: 99%

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Health consequences of vitamin D deficiency in the human body

Glibowski

Iłowiecka

Środek

2021

Postępy Higieny I Medycyny Doświadczalnej

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Quality Control of the Dietary Supplements Containing Selected Fat-Soluble Vitamins D and K

2023

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Nowadays, the most important aspect related to the use of dietary supplements seems to be their quality. There are many reports indicating their insufficient quality primarily related to a much lower content of ingredients or even their absence. Currently, there is an increasing interest in supplementing the diet with various kinds of supplements, including those containing combinations of vitamins and minerals, among which preparations with vitamin D are very popular. This is probably due to the reduced production of this vitamin, depending on the amount of time spent in the sun and the use of UV-filters. Very often, preparations with cholecalciferol also contain vitamin K2, which is associated with their synergistic effect. Therefore, the question arises about the effectiveness of supplementation, which may be correlated with the quality of commonly available dietary supplements. In the presented work, it was undertaken to develop optimal conditions for the qualitative and quantitative determination of vitamins D2, D3 and K2 in dietary supplements available in various forms, using thin-layer chromatography with densitometric detection. As a result, the methodology for analyzing the content of three vitamins from various matrices was developed, optimized and validated in accordance with ICH requirements. The obtained results allow us to conclude that it is reliable and meets the requirements for analytical procedures used in the analysis of medicinal products. Based on the results obtained for examined dietary supplements, it can be stated that the amount of vitamin D3 in analyzed products is basically similar to that declared by the manufacturer, in contrast to vitamin K2, the content of which is diverse. The developed methodology seems to be a good, low-cost and quick way to control the quality of dietary supplements so that they can supplement the human diet and be a wholesome product.

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Impact of Vitamin D on Immunopathology of Hashimoto’s Thyroiditis: From Theory to Practice

Lebiedziński

Lisowska

2023

Nutrients

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Hashimoto’s thyroiditis (HT) is a common autoimmune disease affecting the thyroid gland, characterized by lymphocytic infiltration, damage to thyroid cells, and hypothyroidism, and often requires lifetime treatment with levothyroxine. The disease has a complex etiology, with genetic and environmental factors contributing to its development. Vitamin D deficiency has been linked to a higher prevalence of thyroid autoimmunity in certain populations, including children, adolescents, and obese individuals. Moreover, vitamin D supplementation has shown promise in reducing antithyroid antibody levels, improving thyroid function, and improving other markers of autoimmunity, such as cytokines, e.g., IP10, TNF-α, and IL-10, and the ratio of T-cell subsets, such as Th17 and Tr1. Studies suggest that by impacting various immunological mechanisms, vitamin D may help control autoimmunity and improve thyroid function and, potentially, clinical outcomes of HT patients. The article discusses the potential impact of vitamin D on various immune pathways in HT. Overall, current evidence supports the potential role of vitamin D in the prevention and management of HT, although further studies are needed to fully understand its mechanisms of action and potential therapeutic benefits.

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Witamina D jako związek o działaniu plejotropowym – przegląd aktualnych badań

Cited by 4 publications

References 0 publications

Health consequences of vitamin D deficiency in the human body

Health consequences of vitamin D deficiency in the human body

Quality Control of the Dietary Supplements Containing Selected Fat-Soluble Vitamins D and K

Impact of Vitamin D on Immunopathology of Hashimoto’s Thyroiditis: From Theory to Practice

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