Withanolides of Acnistus breviflorus

Nittala, S. Sarma; Lavie, David

doi:10.1016/0031-9422(81)85277-6

Cited by 31 publications

(20 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 Plants of this genus biosynthesize a complex group of natural C 28 steroidal lactones, known as acnistins, 2 withanolides, 3 and jaborols. 4 As part of a collaborative search program to identify novel naturally occurring anticancer agents, we have investigated Acnistus arborescens (L.) Schlecht.…”

Section: Introductionmentioning

confidence: 99%

New ceramides from acnistus arborescens

Maia¹,

Veras²,

Braz‐Filho³

et al. 2010

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

Duas novas ceramidas N-(4-hidroxifeniletil)octacosamida (1) e rel-(2S,3S,4R,16E)-2-[(2'R)-2'-hidroxinonadecanoilamino]-heneicosadec-16-eno-1,3,4-triol (2) foram isoladas do extrato etanólico de Acnistus arborescens. As estruturas foram elucidadas por métodos espectroscópicos (experimentos de RMN 1D e 2D, EMAR com ionização por electrospray, EM e IV). (2) were isolated from the EtOH extract of Acnistus arborescens. The structures were elucidated by spectroscopic (1D and 2D NMR experiments, HR-ESI-MS, LR-MS and IR) methods. Two new ceramides, N-(4-hydroxyphenethyl)octacosamide (1) and rel-(2S,3S,4R,16E)-2-

show abstract

Section: Introductionmentioning

confidence: 99%

New ceramides from acnistus arborescens

Maia¹,

Veras²,

Braz‐Filho³

et al. 2010

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

show abstract

“…The IR spectrum revealed the presence of several OH groups (3560 and 3405 cm À1 ), and included bands at 1692 and 1708 cm À1 typical for a six-membered cyclic ketone and an a,bunsaturated d-lactone, respectively. The 1 H-NMR spectrum of 1 closely resembled that of 5,6-deoxywithaferin A revealing the same substitution pattern in rings A and B [6]. The spectrum included signals for three tertiary Me groups (d 1.54, 1.32, and 1.04) and one vinylic Me group (d 1.98).…”

mentioning

confidence: 65%

“…The spectrum included signals for three tertiary Me groups (d 1.54, 1.32, and 1.04) and one vinylic Me group (d 1.98). The absence of a signal corresponding to Me(27) and the presence of a 2-H ABd pattern at d 4.73 and 4.68, which was shifted downfield to d 5.23 and 5.18 in diacetate 1a, suggested a substitution with a OH group at C(27) [6]. The olefinic signals at d 6.69 (dd, J 10.0, 4.5 Hz, 1 H ), 5.73 (d, J 9.6 Hz, 1 H ), and 5.50 (br.…”

mentioning

confidence: 99%

ChemInform Abstract: Ajugins C (I) and D (II), New Withanolides from Ajuga parviflora

Khan¹,

Nawaz²,

Ahmad³

et al. 2000

ChemInform

View full text Add to dashboard Cite

show abstract

“…A MeOH extract of leaves and twigs of aeroponically grown W. somnifera, after removing water and hexane soluble constituents, was subjected to size-exclusion, diol, and reversed-phase column chromatography, prep TLC and HPLC affording compounds 1, 3, and 10 known withanolides identified as withaferin A (Xu et al, 2009), 2,3-dihydrowithaferin A-3b-O-sulfate (Xu et al, 2009), viscosalactone B (Pelletier et al, 1981, 27-deoxywithaferin A (Kirson et al, 1970), withanolide A (Neogi et al, 1988), 27-hydroxywithanolide B (Anjaneyulu and Rao, 1997), pubesenolide (Sahai, 1985), jaborosalactone D (Veleiro et al, 1985), 4b,27-dihydroxy-l-oxo-22R-witha-2,5,24-trienolide (Nittala and Lavie, 1981), and 2,3-didehydrosomnifericin (Kuroyanagi et al, 1999) by comparison of their spectroscopic data ( 1 H NMR and LRMS) with those reported. Withanolide 2 was encountered in a fraction generated during the isolation of withaferin A from a 60% aq.…”

Section: Resultsmentioning

confidence: 96%