1995
DOI: 10.1007/bf02245178
|View full text |Cite
|
Sign up to set email alerts
|

Withdrawal from chronic amphetamine elevates baseline intracranial self-stimulation thresholds

Abstract: Intracranial self-stimulation was assessed before, within, and after a chronic amphetamine treatment regimen. Amphetamine was given twice daily 5 days per week for 6 weeks at dosages escalating from 1 to 10 mg/kg per injection. Lateral hypothalamic self-stimulation rate-frequency functions were taken 36 h after the last injection in each weekly series and weekly for 3 weeks following the last injection. Frequency thresholds increased and maximal response rates decreased progressively as a function of amphetami… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

9
45
0
1

Year Published

1998
1998
2022
2022

Publication Types

Select...
4
3

Relationship

0
7

Authors

Journals

citations
Cited by 120 publications
(55 citation statements)
references
References 70 publications
9
45
0
1
Order By: Relevance
“…In replication of previous findings (Epping-Jordan et al 1998;Zacharko 1980a, 1980b;Kokkinidis et al 1986;Barrett 1976, 1980;Lin et al 1999Lin et al , 2000Paterson et al 2000;Watkins et al 2000b;Wise and Munn 1995), both nicotine and amphetamine withdrawal resulted in decreased reward reflected in elevated brain reward thresholds relative to salinetreated rats' and to their own pre-drug baseline thresholds. As anticipated (Epping-Jordan et al 1998;Hildebrand et al 1997Hildebrand et al , 1999Malin et al 1992;Watkins et al 2000b), nicotine withdrawal also led to significant increases in somatic signs.…”
Section: Discussionsupporting
confidence: 53%
See 2 more Smart Citations
“…In replication of previous findings (Epping-Jordan et al 1998;Zacharko 1980a, 1980b;Kokkinidis et al 1986;Barrett 1976, 1980;Lin et al 1999Lin et al , 2000Paterson et al 2000;Watkins et al 2000b;Wise and Munn 1995), both nicotine and amphetamine withdrawal resulted in decreased reward reflected in elevated brain reward thresholds relative to salinetreated rats' and to their own pre-drug baseline thresholds. As anticipated (Epping-Jordan et al 1998;Hildebrand et al 1997Hildebrand et al , 1999Malin et al 1992;Watkins et al 2000b), nicotine withdrawal also led to significant increases in somatic signs.…”
Section: Discussionsupporting
confidence: 53%
“…Brain reward threshold elevation is an operational measure of this symptom because it reflects diminished sensitivity to rewarding electrical stimuli. In rats, withdrawal from drugs of abuse belonging to diverse pharmacological classes, such as nicotine (Epping-Jordan et al 1998 Watkins et al 2000b), amphetamine Zacharko 1980a, 1980b;Kokkinidis et al 1980Kokkinidis et al , 1986 Barrett 1976, 1980;Lin et al 1999Lin et al , 2000Paterson et al 2000;Wise and Munn 1995), cocaine (Baldo et al 1999;Kokkinidis and McCarter 1990; Koob 1991, 1992a;Markou et al 1992) morphine (Schulteis et al 1994) and ethanol (Schulteis et al 1995) elevated brain stimulation reward thresholds.In addition to the affective aspects of drug withdrawal reflected in threshold elevations, nicotine, opiate, or ethanol withdrawal also lead to alterations in a set of behaviors termed somatic signs. In the case of nicotine, these somatic signs are primarily gasps, writhes, eye blinks, and ptosis (Epping-Jordan et al 1998;Hildebrand et al 1997Hildebrand et al , 1999Malin et al 1992).…”
mentioning
confidence: 99%
See 1 more Smart Citation
“…Elevations in brain reward thresholds are mediated by a decrease in the positive reinforcing properties of pleasurable electrical stimuli and have been suggested to reflect an anhedonic-state . Elevations in brain reward thresholds have also been observed after the discontinuation of the administration of drugs of abuse such as amphetamine, fentanyl, and alcohol (Bruijnzeel et al, 2006;Schulteis et al, 1995;Wise and Munn, 1995). Antidepressant treatments, such as co-administration of the selective serotonin reuptake inhibitor fluoxetine and the serotonin-1A receptor antagonist p-MPPI ([4-(2'-methoxy-phenyl)-1-[2'-(n-(2"-pyridinyl)-p-iodobenzamido]-ethyl-piperazine]), partly prevent the elevations in brain reward thresholds associated with spontaneous nicotine withdrawal (Harrison et al, 2001).…”
Section: Introductionmentioning
confidence: 99%
“…The state of the brain reward system was investigated using a discrete-trial intracranial self-stimulation procedure. This procedure was used as it provides a quantitative measure of the emotional aspects of drug withdrawal (Bruijnzeel et al, 2006;Schulteis et al, 1995;Wise and Munn, 1995). The effect of [D-His 26 ]-NPY on nicotine withdrawal was investigated as this compound, in contrast to NPY, has a low affinity for the Y5 receptor (NPY, Ki of 0.28 nM for Y1, Ki of 1.5 nM for Y5; ]-NPY, Ki of 2.0 nM for Y1, Ki of 34.6 nM for Y5) (Mullins et al, 2001).…”
Section: Introductionmentioning
confidence: 99%