Withdrawal from Cocaine Self-Administration Normalizes Deficits in Proliferation and Enhances Maturity of Adult-Generated Hippocampal Neurons

Noonan, Michele A.; Choi, Kwang Ho; Self, David W.; Eisch, Amelia J.

doi:10.1523/jneurosci.4661-07.2008

Cited by 100 publications

(119 citation statements)

References 90 publications

(115 reference statements)

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“…Thus, the extant literature would suggest that the observed hippocampal alterations in cocaine-addicted subjects could be a result of chronic cocaine use and that disruptions in dorsal hippocampal cholinergic regulation could alter the ability of cocaine-addicted subjects to extinguish cocainecued learning. Enhancement of hippocampus neurogenesis by a cholinergic agonist (Kotani et al, 2008), a process inhibited by chronic cocaine administration (Noonan et al, 2008;Yamaguchi et al, 2004), also points to putative function of the cholinergic system in cocaine-induced hippocampal functioning.…”

Section: Regions Of Interestmentioning

confidence: 94%

Altered Neural Cholinergic Receptor Systems in Cocaine-Addicted Subjects

Adinoff

Devous

Williams

et al. 2010

Neuropsychopharmacol

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Changes in the brain's cholinergic receptor systems underlie several neuropsychiatric disorders, including Alzheimer's disease, schizophrenia, and depression. An emerging preclinical literature also reveals that acetylcoholine may have an important function in addictive processes, including reward, learning, and memory. This study was designed to assess alterations in cholinergic receptor systems in limbic regions of abstinent cocaine-addicted subjects compared with healthy controls. On three separate days, 23 1-to 6-week abstinent, cocaine-(and mostly nicotine-) addicted subjects and 22 sex-, age-, and race-matched control subjects were administered the muscarinic and nicotinic cholinergic agonist physostigmine, the muscarinic antagonist scopolamine, and saline. Regional cerebral blood flow (rCBF) after each infusion was determined using single photon emission-computed tomography. Both cholinergic probes induced rCBF changes (po0.005) in relatively distinct, cholinergic-rich, limbic brain regions. After physostigmine, cocaine-addicted subjects showed altered rCBF, relative to controls, in limbic regions, including the left hippocampus, left amygdala, and right insula. Group differences in the right dorsolateral prefrontal cortex, posterior cingulate, and middle temporal gyrus were also evident. Scopolamine also revealed group differences in the left hippocampus and right insula as well as the posterior cingulate and middle temporal gyrus. Cocaine addicted and controls differ in their subcortical, limbic, and cortical response to cholinergic probes in areas relevant to craving, learning, and memory. Cholinergic systems may offer a pharmacologic target for cocaine addiction treatment.

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Section: Regions Of Interestmentioning

confidence: 94%

Altered Neural Cholinergic Receptor Systems in Cocaine-Addicted Subjects

Adinoff

Devous

Williams

et al. 2010

Neuropsychopharmacol

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“…Likewise, cocaine abuse is also negatively associated with some facets of adult hippocampal neurogenesis. Both short-and longterm treatment of cocaine reduces proliferation in the dentate gyrus, but the effect on survival and dendritic maturation is not always consistent, possibly caused by the use of different animal strains and various drug administration protocols (Eisch 2002;Yamaguchi et al 2004;Dominguez-Escriba et al 2006;Noonan et al 2008;Mustroph et al 2011). Negative effects of cocaine on cell proliferation were concomitant with impairments in working memory, even during abstinence from high dosage cocaine self-administration (Sudai et al 2011).…”

Section: Drug Abuse and Addictionmentioning

confidence: 99%

Adult Neurogenesis and Psychiatric Disorders

Kang

Wen

Song

et al. 2016

Cold Spring Harb Perspect Biol

164

118

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Psychiatric disorders continue to be among the most challenging disorders to diagnose and treat because there is no single genetic or anatomical locus that is causative for the disease. Current treatments are often blunt tools used to ameliorate the most severe symptoms, at the risk of disrupting functional neural systems. There is a critical need to develop new therapeutic strategies that can target circumscribed functional or anatomical domains of pathology. Adult hippocampal neurogenesis may be one such domain. Here, we review the evidence suggesting that adult hippocampal neurogenesis plays a role in emotional regulation and forms of learning and memory that include temporal and spatial memory encoding and context discrimination, and that its dysregulation is associated with psychiatric disorders, such as affective disorders, schizophrenia, and drug addiction. Further, adult neurogenesis has proven to be an effective model to investigate basic processes of neuronal development and converging evidence suggests that aberrant neural development may be an etiological factor, even in late-onset diseases. Constitutive neurogenesis in the hippocampus of the mature brain reflects large-scale plasticity unique to this region and could be a potential hub for modulation of a subset of cognitive and affective behaviors that are affected by multiple psychiatric disorders.

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“…It is beyond the scope of this review to discuss all drugs of abuse; therefore, we will focus on cocaine, amphetamine, nicotine, ethanol, opiates, and cannabis, examining for each drug the effects of acute administration, chronic administration, and withdrawal on hippocampus learning and hippocampal synaptic plasticity. In addition, because there is substantial evidence showing that self-administration and yoked-administration of drugs result in the same effects on hippocampal plasticity (Thomas and Everitt 2001; Thomas et al 2003;Yamaguchi et al 2004Yamaguchi et al , 2005Domínguez-Escribà et al 2006;Noonan et al 2008), we will review studies using both contingent and noncontingent drug administration together. Evidence from human subject studies along with laboratory animal studies will be reviewed.…”

mentioning

confidence: 99%

Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: contributions to development and maintenance of addiction

2016

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It has long been hypothesized that conditioning mechanisms play major roles in addiction. Specifically, the associations between rewarding properties of drugs of abuse and the drug context can contribute to future use and facilitate the transition from initial drug use into drug dependency. On the other hand, the self-medication hypothesis of drug abuse suggests that negative consequences of drug withdrawal result in relapse to drug use as an attempt to alleviate the negative symptoms. In this review, we explored these hypotheses and the involvement of the hippocampus in the development and maintenance of addiction to widely abused drugs such as cocaine, amphetamine, nicotine, alcohol, opiates, and cannabis. Studies suggest that initial exposure to stimulants (i.e., cocaine, nicotine, and amphetamine) and alcohol may enhance hippocampal function and, therefore, the formation of augmented drug-context associations that contribute to the development of addiction. In line with the self-medication hypothesis, withdrawal from stimulants, ethanol, and cannabis results in hippocampus-dependent learning and memory deficits, which suggest that an attempt to alleviate these deficits may contribute to relapse to drug use and maintenance of addiction. Interestingly, opiate withdrawal leads to enhancement of hippocampus-dependent learning and memory. Given that a conditioned aversion to drug context develops during opiate withdrawal, the cognitive enhancement in this case may result in the formation of an augmented association between withdrawalinduced aversion and withdrawal context. Therefore, individuals with opiate addiction may return to opiate use to avoid aversive symptoms triggered by the withdrawal context. Overall, the systematic examination of the role of the hippocampus in drug addiction may help to formulate a better understanding of addiction and underlying neural substrates.Addiction is a major worldwide health problem that results in maladaptive behavioral changes, some that can last a lifetime. This behavioral plasticity, often times maladaptive, must be associated changes in neural plasticity. In fact, it has been noted multiple times that there is a high degree of overlap between the neurobiology of learning and memory and the neurobiology of addiction

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Withdrawal from Cocaine Self-Administration Normalizes Deficits in Proliferation and Enhances Maturity of Adult-Generated Hippocampal Neurons

Cited by 100 publications

References 90 publications

Altered Neural Cholinergic Receptor Systems in Cocaine-Addicted Subjects

Altered Neural Cholinergic Receptor Systems in Cocaine-Addicted Subjects

Adult Neurogenesis and Psychiatric Disorders

Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: contributions to development and maintenance of addiction

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