Withdrawal-Induced Antihypertensive Effect of Vasopressin in Doca-Salt Hypertension

Chiu, Edward K.Y.; McNeill, J. Robert

doi:10.1093/ajh/2.6.458

Cited by 4 publications

(3 citation statements)

References 3 publications

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“…This difference is not strain related because a WAP can be elicited in WKY when they are rendered hypertensive by a DOCAsalt regimen. 9 Taken together, our data in the SHR and the DOCA-salt hypertensive rat suggest that the WAP is related neither to strain nor to the duration of hypertension; rather, it appears that it is related to the level of hypertension. Accordingly, we suggest that the term "antihypertensive" effect of AVP withdrawal is apt.…”

Section: Discussionmentioning

confidence: 55%

“…Because a WAP to AVP was similarly demonstrated in the DOCA-salt hypertensive rat, 9 it follows that a specific interaction with AVP may not be restricted to the SHR but rather may be generally found in all hypertensive animals. Despite extensive literature on the cardiovascular actions of AVP, a specific interaction of this nature had never been demonstrated.…”

Section: Discussionmentioning

confidence: 96%

“…Recently, however, we were able to demonstrate the WAP to AVP in the deoxycorticosterone acetate (DOCA)-salt hypertensive rat. 9 Because the hypertensive state in the DOCA-salt rat was produced over a period of 3 weeks on an experimental regimen, it appears that the duration of hypertensive state is a relatively unimportant determinant for the expression of the WAP. On the other hand, we observed a strong correlation between the magnitude of the WAP and the level of the initial control blood pressure.…”

Section: Discussionmentioning

confidence: 99%

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Antihypertensive effect of vasopressin withdrawal in young and adult spontaneously hypertensive rats.

Chiu

McNeill

1989

Hypertension

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The extent to which age influences the effect of prolonged intravenous infusion and withdrawal of arginine vasopressin (AVP) on blood pressure was investigated in spontaneously hypertensive rats (SHR) and their normotensive Wistar-Kyoto controls (WKY) of 6-, 10-, 14-, 18-, and 22-week age groups. The pressor response to AVP (20 ng/kg/min for 3 hours) was relatively well maintained in WKY but showed an age-dependent tachyphylaxis in SHR. After cessation of the infusion, arterial pressure of SHR fell in all age groups. In contrast, withdrawal of AVP in WKY resulted in little or no hypotensive response. Thus, a withdrawal-induced antihypertensive phenomenon (WAP) to AVP was specific to SHR. The magnitude of the WAP was significantly correlated with the level of initial blood pressure in SHR (r=-0.81,p<0.001). The magnitude of the tachyphylaxis during the AVP infusion was also correlated with the level of initial blood pressure in SHR (r=-0.66, p<0.001). Accordingly, a significant correlation was found between the magnitude of the WAP and the degree of tachyphylaxis to the pressor activity of AVP in SHR (r=0.69, p< 0.001). The significance of this is unknown, but it might mean that a common underlying mechanism existed in the expression of the tachyphylactic phenomenon and the WAP in SHR. Finally, an apparent enhancement in the baroreceptor reflex sensitivity was observed in both SHR and WKY during the infusion of AVP, but the magnitude of this enhancement appeared to be greater in SHR than in WKY. We conclude that in all age groups, a WAP to AVP is observed in SHR but not in WKY; the magnitude of the WAP appears to depend on the level of the hypertension in SHR. (Hypertension 1989;14:66-72) P reviously, 1 -2 we described a hypotensive response that occurred in spontaneously hypertensive rats (SHR) after the cessation of a prolonged intravenous infusion of a pressor dose of arginine vasopressin (AVP). This fall of arterial pressure below basal control levels did not occur in normotensive Wistar-Kyoto rats (WKY). Furthermore, the hypotensive response in SHR was of a magnitude (approximately 45-50 mm Hg) sufficient to reduce arterial pressure in these SHR to normotensive levels. Thus, a withdrawal-induced antihypertensive phenomenon (WAP) was specific to SHR. The WAP was reduced or absent when angiotensin II or phenylephrine was infused at pressor doses.1 " 3 Accordingly, the WAP appeared to be specific for AVP in SHR. The specificity in

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

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Antihypertensive effect of vasopressin withdrawal in young and adult spontaneously hypertensive rats.

Chiu

McNeill

1989

Hypertension

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Radiotelemetric versus externalized catheter monitoring of blood pressure: effect of vasopressin in spontaneous hypertension

Balakrishnan

Tatchum-Talom

McNeill

1998

Journal of Pharmacological and Toxicological Methods

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A novel vasopressin peptide lowers blood pressure through decreases in cardiac output

Yu¹,

Ghosh²,

McNeill³

2003

Can. J. Physiol. Pharmacol.

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The changes in blood pressure, cardiac output, and total peripheral conductance evoked by the novel hypotensive arginine vasopressin (AVP) - like peptide, d(CH2)5[D-Tyr(Et)2,Arg3,Val4,Arg7,Eda9]AVP (HYPO-AVP), were recorded in conscious unrestrained Sprague-Dawley rats implanted with radiotelemetry pressure transducers and ultrasonic transit-time flowprobes. Intravenous infusions of 0.6, 1.0, 2.0, and 4.0 microg x kg(-1) x min(-1) of HYPO-AVP evoked dose-related decreases in blood pressure. At the lowest dose of 0.6 microg x kg(-1) x min(-1), the fall in blood pressure was associated with a small but significant increase in total peripheral conductance. Cardiac output was unchanged. In contrast, at the three higher doses of 1.0, 2.0, and 4.0 microg x kg(-1) x min(-1), the fall in blood pressure was related to a dramatic fall in cardiac output. Indeed, total peripheral conductance decreased, preventing blood pressure from falling further. These hemodynamic findings should help to direct future research into the mechanism of the putative hypotensive property of vasopressin, a property that attenuates the well established blood pressure elevating actions of the peptide.

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Withdrawal-Induced Antihypertensive Effect of Vasopressin in Doca-Salt Hypertension

Cited by 4 publications

References 3 publications

Antihypertensive effect of vasopressin withdrawal in young and adult spontaneously hypertensive rats.

Antihypertensive effect of vasopressin withdrawal in young and adult spontaneously hypertensive rats.

Radiotelemetric versus externalized catheter monitoring of blood pressure: effect of vasopressin in spontaneous hypertension

A novel vasopressin peptide lowers blood pressure through decreases in cardiac output

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